2CX4

Crystal structure of a bacterioferritin comigratory protein peroxiredoxin from the Aeropyrum pernix K1 (form-2 crystal)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2cx4a2	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	Glutathione peroxidase-like	Bacterioferritin comigratory protein	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
A	d2cx4a3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
B	d2cx4b2	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	Glutathione peroxidase-like	Bacterioferritin comigratory protein	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
B	d2cx4b3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
C	d2cx4c2	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	Glutathione peroxidase-like	Bacterioferritin comigratory protein	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
C	d2cx4c3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
D	d2cx4d2	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	Glutathione peroxidase-like	Bacterioferritin comigratory protein	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
D	d2cx4d3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
E	d2cx4e2	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	Glutathione peroxidase-like	Bacterioferritin comigratory protein	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
E	d2cx4e3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
F	d2cx4f2	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	Glutathione peroxidase-like	Bacterioferritin comigratory protein	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
F	d2cx4f3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
G	d2cx4g2	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	Glutathione peroxidase-like	Bacterioferritin comigratory protein	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
G	d2cx4g3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
H	d2cx4h2	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	Glutathione peroxidase-like	Bacterioferritin comigratory protein	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)
H	d2cx4h3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Aeropyrum pernix K1 ) [TaxId: 272557 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Glutathione peroxidase-like	8057906	4000042	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thioredoxin-like	8057907	3000031	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Thioredoxin-like	8057907	3000031	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Thioredoxin-like	8057907	3000031	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Thioredoxin-like	8057907	3000031	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Thioredoxin-like	8057907	3000031	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Thioredoxin-like	8057907	3000031	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Thioredoxin-like	8057907	3000031	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Thioredoxin-like	8057907	3000031	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00578	e2cx4A1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578	ECOD (1.6)
B	PF00578	e2cx4B1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578	ECOD (1.6)
C	PF00578	e2cx4C1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578	ECOD (1.6)
D	PF00578	e2cx4D1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578	ECOD (1.6)
E	PF00578	e2cx4E1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578	ECOD (1.6)
F	PF00578	e2cx4F1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578	ECOD (1.6)
G	PF00578	e2cx4G1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578	ECOD (1.6)
H	PF00578	e2cx4H1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00578	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
B	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
C	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
D	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
E	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
F	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
G	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
H	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00578	AhpC/TSA family (AhpC-TSA)	AhpC/TSA family	This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	bacterioferritin comigratory protein	peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR024706	Peroxiredoxin, AhpC-type	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013766	Thioredoxin domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000866	Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.