Annotations: 2CUP

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2cupa1	Small proteins	Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	LIM domain	Four and a half LIM domains protein 1, FHL-1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2cupa5	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2cupa4	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LIM_N_2	e2cupA2	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: LIM_N_2	ECOD (1.6)
A	LIM_N_4	e2cupA4	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: LIM_N_4	ECOD (1.6)
A	LIM_C_2	e2cupA3	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: LIM_C_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.110.10	Mainly Beta	Ribbon	Cysteine Rich Protein	Cysteine Rich Protein	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00412	LIM domain (LIM)	LIM domain	This family represents two copies of the LIM structural domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Skeletal muscle LIM-protein 1	protein binding binding transmembrane transporter binding cation binding ion binding metal ion binding small molecule binding	developmental process cellular developmental process cell differentiation cellular process regulation of localization regulation of biological process regulation of potassium ion transport transport regulation of transport regulation of monoatomic ion transport biological regulation positive regulation of biological process establishment of localization metal ion transport developmental process cellular developmental process cell differentiation cellular process regulation of localization regulation of biological process regulation of potassium ion transport transport regulation of transport regulation of monoatomic ion transport biological regulation positive regulation of biological process establishment of localization metal ion transport localization positive regulation of potassium ion transport positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport potassium ion transport monoatomic cation transport regulation of metal ion transport anatomical structure morphogenesis animal organ development anatomical structure development animal organ morphogenesis regulation of cell cycle phase transition regulation of cellular process negative regulation of biological process negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cellular process negative regulation of cell cycle phase transition cell cycle regulation of cell cycle cell cycle process negative regulation of G1/S transition of mitotic cell cycle negative regulation of mitotic cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition negative regulation of cell cycle process regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition G2/M transition of mitotic cell cycle cell cycle G2/M phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle G2/M phase transition negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle muscle structure development muscle organ development regulation of growth regulation of cellular component organization growth negative regulation of cell growth regulation of cell growth cell growth cellular component organization negative regulation of growth cellular component organization or biogenesis regulation of membrane depolarization membrane depolarization regulation of biological quality regulation of membrane potential monoatomic ion transmembrane transport potassium ion transmembrane transport regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport regulation of transporter activity monoatomic cation transmembrane transport regulation of potassium ion transmembrane transporter activity regulation of monoatomic ion transmembrane transporter activity inorganic ion transmembrane transport regulation of potassium ion transmembrane transport inorganic cation transmembrane transport transmembrane transport regulation of molecular function regulation of transmembrane transport regulation of monoatomic cation transmembrane transport	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR042997	Four and a half LIM domains protein 1	Family
A	IPR001781	Zinc finger, LIM-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q13642	myopathy, reducing body, X-linked, early-onset, severe myopathy, reducing body, X-linked, childhood-onset X-linked myopathy with postural muscle atrophy X-linked scapuloperoneal muscular dystrophy Emery-Dreifuss muscular dystrophy Liver Cirrhosis, Experimental X-linked Emery-Dreifuss muscular dystrophy hypertrophic cardiomyopathy ulcerative colitis limb-girdle muscular dystrophy lung cancer malignant ependymoma medulloblastoma adrenal cortex carcinoma muscular dystrophy myopathy, reducing body, X-linked, early-onset, severe myopathy, reducing body, X-linked, childhood-onset X-linked myopathy with postural muscle atrophy X-linked scapuloperoneal muscular dystrophy Emery-Dreifuss muscular dystrophy Liver Cirrhosis, Experimental X-linked Emery-Dreifuss muscular dystrophy hypertrophic cardiomyopathy ulcerative colitis limb-girdle muscular dystrophy lung cancer malignant ependymoma medulloblastoma adrenal cortex carcinoma muscular dystrophy atopic eczema breast fibroadenoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma dermatomyositis psoriasis Down syndrome Sjogren syndrome intellectual disability Uruguay Faciocardiomusculoskeletal syndrome lung carcinoma malignant glioma muscle tissue disease arthrogryposis myopathy breast cancer chronic kidney disease ovarian cancer Crohn disease pancreatic intraductal papillary-mucinous neoplasm dilated cardiomyopathy reducing body myopathy ductal breast carcinoma in situ head and neck cancer subependymal giant cell astrocytoma invasive ductal breast carcinoma lung adenocarcinoma malignant colon neoplasm malignant mesothelioma muscular disease astrocytic tumor breast carcinoma non-small cell lung carcinoma chronic obstructive pulmonary disease pancreatic ductal adenocarcinoma cystic fibrosis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia distal myopathy

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.