2CT9

The crystal structure of calcineurin B homologous proein 1 (CHP1)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ct9a1	All alpha proteins	EF Hand-like	EF-hand	automated matches	automated matches	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d2ct9a2	Artifacts	Tags	Tags	Tags	C-terminal Tags	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d2ct9b1	All alpha proteins	EF Hand-like	EF-hand	automated matches	automated matches	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d2ct9b2	Artifacts	Tags	Tags	Tags	C-terminal Tags	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EF-hand	8062943	3001983	SCOP2B (2022-06-29)
B	SCOP2 Family	Calmodulin-like	8062942	4000924	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	EF-hand	8062943	3001983	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e2ct9A6	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF13499	e2ct9A5	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)
B	F_UNCLASSIFIED	e2ct9B6	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF13499	e2ct9B5	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Calcium-binding protein p22	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity protein binding kinase binding enzyme binding monoatomic cation transmembrane transporter activity metal cation:monoatomic cation antiporter activity proton transmembrane transporter activity sodium:proton antiporter activity sodium ion transmembrane transporter activity secondary active transmembrane transporter activity antiporter activity active monoatomic ion transmembrane transporter activity metal cation:proton antiporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity cytoskeletal protein binding microtubule binding tubulin binding calcium-dependent protein binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein localization negative regulation of protein transport regulation of localization establishment of protein localization negative regulation of nucleocytoplasmic transport nitrogen compound transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein localization negative regulation of protein transport regulation of localization establishment of protein localization negative regulation of nucleocytoplasmic transport nitrogen compound transport regulation of cellular process nucleocytoplasmic transport nuclear transport negative regulation of biological process negative regulation of intracellular protein transport negative regulation of transport localization import into nucleus cellular macromolecule localization establishment of localization in cell regulation of intracellular transport regulation of biological process organic substance transport negative regulation of establishment of protein localization intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus establishment of localization establishment of protein localization to organelle regulation of intracellular protein transport intracellular protein transport cellular localization regulation of protein localization transport regulation of protein localization to nucleus negative regulation of protein import into nucleus regulation of protein import into nucleus protein import into nucleus negative regulation of cellular process negative regulation of protein localization negative regulation of intracellular transport regulation of transport biological regulation regulation of establishment of protein localization regulation of protein transport negative regulation of protein localization to nucleus protein transport regulation of cellular localization macromolecule localization protein localization to organelle membrane organization membrane fusion microtubule bundle formation organelle organization microtubule cytoskeleton organization microtubule-based process cytoskeleton organization regulation of protein stability regulation of biological quality protein stabilization protein export from nucleus nuclear export negative regulation of hydrolase activity regulation of phosphatase activity regulation of catalytic activity negative regulation of catalytic activity negative regulation of phosphate metabolic process negative regulation of cellular metabolic process negative regulation of phosphatase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of dephosphorylation phosphorus metabolic process regulation of dephosphorylation cellular metabolic process negative regulation of metabolic process dephosphorylation negative regulation of molecular function regulation of cellular metabolic process regulation of molecular function regulation of hydrolase activity negative regulation of phosphorus metabolic process regulation of phosphorus metabolic process metabolic process regulation of metabolic process negative regulation of post-translational protein modification regulation of protein modification process regulation of protein ubiquitination regulation of primary metabolic process organic substance metabolic process protein ubiquitination negative regulation of protein modification process protein metabolic process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification macromolecule metabolic process post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of biological process positive regulation of establishment of protein localization positive regulation of protein transport positive regulation of cellular process positive regulation of transport positive regulation of protein localization regulation of protein phosphorylation protein phosphorylation phosphorylation negative regulation of protein phosphorylation regulation of phosphorylation negative regulation of phosphorylation organelle membrane fusion vesicle-mediated transport vesicle organization organelle fusion vesicle fusion cellular response to stimulus response to stimulus response to pH cellular response to pH response to abiotic stimulus cellular response to acidic pH cellular response to abiotic stimulus response to acidic pH cellular response to environmental stimulus protein autophosphorylation regulation of protein autophosphorylation negative regulation of protein autophosphorylation positive regulation of cation transmembrane transport sodium ion transmembrane transport regulation of sodium ion transport regulation of sodium ion transmembrane transport positive regulation of sodium ion transport positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation transport regulation of monoatomic ion transport proton transmembrane transport inorganic ion transmembrane transport inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport positive regulation of sodium ion transmembrane transporter activity monoatomic ion transmembrane transport regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport metal ion transport regulation of transporter activity monoatomic cation transmembrane transport regulation of sodium ion transmembrane transporter activity positive regulation of molecular function positive regulation of transmembrane transport positive regulation of sodium ion transmembrane transport monoatomic ion transport regulation of metal ion transport regulation of monoatomic ion transmembrane transporter activity regulation of proton transport positive regulation of sodium:proton antiporter activity regulation of sodium:proton antiporter activity positive regulation of transporter activity positive regulation of ion transmembrane transporter activity regulation of monoatomic cation transmembrane transport sodium ion transport cellular biosynthetic process negative regulation of DNA-binding transcription factor activity RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process negative regulation of NF-kappaB transcription factor activity nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of lipid metabolic process lipid biosynthetic process positive regulation of cellular metabolic process positive regulation of phosphate metabolic process phospholipid metabolic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of lipid metabolic process positive regulation of phosphorus metabolic process positive regulation of phospholipid biosynthetic process regulation of phospholipid metabolic process phospholipid biosynthetic process regulation of phospholipid biosynthetic process positive regulation of phospholipid metabolic process positive regulation of lipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process regulation of lipid biosynthetic process lipid metabolic process cytoplasmic microtubule organization supramolecular fiber organization regulation of transferase activity negative regulation of kinase activity negative regulation of transferase activity regulation of kinase activity negative regulation of protein kinase activity regulation of protein kinase activity positive regulation of glycoprotein metabolic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process glycoprotein biosynthetic process glycoprotein metabolic process regulation of glycoprotein metabolic process regulation of protein glycosylation positive regulation of protein metabolic process positive regulation of protein glycosylation positive regulation of protein modification process regulation of glycoprotein biosynthetic process positive regulation of glycoprotein biosynthetic process carbohydrate derivative biosynthetic process protein glycosylation glycosylation macromolecule glycosylation positive regulation of cellular biosynthetic process homeostatic process regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis vesicle localization establishment of organelle localization establishment of vesicle localization vesicle targeting organelle localization membrane docking calcineurin-NFAT signaling cascade signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication negative regulation of calcineurin-NFAT signaling cascade regulation of intracellular signal transduction intracellular signaling cassette regulation of calcineurin-mediated signaling regulation of calcium-mediated signaling signal transduction regulation of calcineurin-NFAT signaling cascade regulation of signaling negative regulation of response to stimulus negative regulation of calcium-mediated signaling negative regulation of signal transduction calcium-mediated signaling regulation of response to stimulus regulation of cell communication negative regulation of calcineurin-mediated signaling calcineurin-mediated signaling protein targeting regulation of protein targeting to membrane regulation of protein localization to membrane establishment of protein localization to membrane positive regulation of protein localization to membrane localization within membrane protein localization to membrane protein targeting to membrane regulation of protein targeting positive regulation of protein targeting to membrane	cell periphery plasma membrane membrane cellular anatomical entity membrane microdomain membrane raft membrane-bounded organelle intracellular anatomical structure transport vesicle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle cell periphery plasma membrane membrane cellular anatomical entity membrane microdomain membrane raft membrane-bounded organelle intracellular anatomical structure transport vesicle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle Golgi membrane Golgi apparatus bounding membrane of organelle organelle membrane protein-containing complex transporter complex endoplasmic reticulum-Golgi intermediate compartment nucleus endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002048	EF-hand domain	Domain
A, B	IPR011992	EF-hand domain pair	Homologous Superfamily
A, B	IPR018247	EF-Hand 1, calcium-binding site	Binding Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.