Annotations: 2CPO

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2cpoa1	All alpha proteins	EF Hand-like	Cloroperoxidase	Cloroperoxidase	Cloroperoxidase	(Leptoxyphium fumago ) [TaxId: 5474 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cloroperoxidase	8038909	3000251	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Cloroperoxidase	8038906	3000251	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e2cpoA2	A: alpha arrays	X: EF-hand	H: Cloroperoxidase (From Topology)	T: Cloroperoxidase	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF01328	e2cpoA1	A: alpha arrays	X: EF-hand	H: Cloroperoxidase (From Topology)	T: Cloroperoxidase	F: PF01328	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.489.10	Mainly Alpha	Orthogonal Bundle	Chloroperoxidase	Chloroperoxidase-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01328	Peroxidase, family 2 (Peroxidase_2)	Peroxidase, family 2	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CHLOROPEROXIDASE	cation binding ion binding binding metal ion binding small molecule binding peroxidase activity haloperoxidase activity oxidoreductase activity halogenase activity antioxidant activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on peroxide as acceptor chloride peroxidase activity catalytic activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000028	Chloroperoxidase	Domain
A	IPR036851	Chloroperoxidase-like superfamily	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	PCA	Parent Component: GLN RESID: AA0031 PSI-MOD : 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	chloride peroxidase (heme dependent) M-CSA #250	The heme-dependent chloroperoxidase (CPO) is a ~250 residue heme-containing glycoprotein that is secreted by various fungi. It was first identified in Caldariomyces fumago where it catalyses the hydrogen peroxide-dependent chlorination of cyclopentanedione during the biosynthesis of the antibiotic caldarioymcin. As with many of the peroxidases, it also catalyses the iodination and bromination of a wide range of substrates, dehydrogenation reactions, catalyse-type reactions (facilitating the decomposition of hydrogen peroxide to oxygen and water) and P450-like oxygen insertion reactions. The capability of chloroperoxidase to perform these diverse reactions makes it one of the most versatile of all known heme proteins.	Defined by 4 residues: CYS:A-30 [auth A-29]HIS:A-106 [auth A-105]ASP:A-107 [auth A-106]GLU:A-184 [auth A-183] \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 1.11.1.10 (PDB Primary Data) Search M-CSA Motif + EC 1.11.1.10

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.