Annotations: 2CPG

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2cpga_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	CopG-like	Transcriptional repressor CopG	(Streptococcus agalactiae ) [TaxId: 1311 ],	SCOPe (2.08)
B	d2cpgb_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	CopG-like	Transcriptional repressor CopG	(Streptococcus agalactiae ) [TaxId: 1311 ],	SCOPe (2.08)
C	d2cpgc_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	CopG-like	Transcriptional repressor CopG	(Streptococcus agalactiae ) [TaxId: 1311 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	CopG-like	8025055	4000608	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ribbon-helix-helix	8037434	3000295	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Ribbon-helix-helix	8037434	3000295	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ribbon-helix-helix	8037434	3000295	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RHH_1	e2cpgA1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: RHH_1	ECOD (1.6)
B	RHH_1	e2cpgB1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: RHH_1	ECOD (1.6)
C	RHH_1	e2cpgC1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: RHH_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.1220.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant	Met repressor-like	CATH (4.3.0)
B	1.10.1220.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant	Met repressor-like	CATH (4.3.0)
C	1.10.1220.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant	Met repressor-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF01402	Ribbon-helix-helix protein, copG family (RHH_1)	Ribbon-helix-helix protein, copG family	The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement [2]. The helix-turn-helix-like structure is involved in dimerisation and not DNA b ...	The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement [2]. The helix-turn-helix-like structure is involved in dimerisation and not DNA binding as might have been expected [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	TRANSCRIPTIONAL REPRESSOR COPG	sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding	cellular process plasmid maintenance regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process cellular process plasmid maintenance regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process	protein-containing complex protein-DNA complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR013321	Arc-type ribbon-helix-helix	Homologous Superfamily
A, B, C	IPR010985	Ribbon-helix-helix	Homologous Superfamily
A, B, C	IPR002145	Ribbon-helix-helix protein, CopG	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.