Annotations: 2CP9

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2cp9a1	All alpha proteins	RuvA C-terminal domain-like	UBA-like	TS-N domain	Elongation factor Ts (EF-Ts), N-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2cp9a3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2cp9a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	TS-N domain	8026805	4002887	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	UBA-like	8039184	3001235	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UBA	e2cp9A1	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: UBA	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Elongation factor Ts, mitochondrial	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding translation elongation factor activity nucleic acid binding translation factor activity, RNA binding RNA binding	regulation of cellular process mitochondrial translation cellular biosynthetic process regulation of mitochondrial gene expression organonitrogen compound biosynthetic process mitochondrial gene expression regulation of primary metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process protein metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process regulation of cellular process mitochondrial translation cellular biosynthetic process regulation of mitochondrial gene expression organonitrogen compound biosynthetic process mitochondrial gene expression regulation of primary metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process protein metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of mitochondrial translation regulation of translation regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of DNA-templated transcription elongation nucleobase-containing compound biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process DNA-templated transcription elongation organic cyclic compound biosynthetic process regulation of DNA-templated transcription translational elongation mitochondrial translational elongation	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen mitochondrial matrix

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR014039	Translation elongation factor EFTs/EF1B, dimerisation	Domain
A	IPR018101	Translation elongation factor Ts, conserved site	Conserved Site
A	IPR001816	Translation elongation factor EFTs/EF1B	Family
A	IPR036402	Elongation factor Ts, dimerisation domain superfamily	Homologous Superfamily
A	IPR009060	UBA-like superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P43897	fatal mitochondrial disease due to combined oxidative phosphorylation defect type 3 cardiomyopathy adenoma dilated cardiomyopathy Leigh syndrome malignant glioma osteosarcoma endogenous depression hypertrophic cardiomyopathy lung cancer medulloblastoma psoriasis Combined Oxidative Phosphorylation Deficiency 3 intellectual disability malignant ependymoma fatal mitochondrial disease due to combined oxidative phosphorylation defect type 3 cardiomyopathy adenoma dilated cardiomyopathy Leigh syndrome malignant glioma osteosarcoma endogenous depression hypertrophic cardiomyopathy lung cancer medulloblastoma psoriasis Combined Oxidative Phosphorylation Deficiency 3 intellectual disability malignant ependymoma rhabdomyolysis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.