Annotations: 2CHV

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08542	e2chvA5	A: alpha arrays	X: DNA polymerase III clamp loader subunits, C-terminal domain (From Topology)	H: DNA polymerase III clamp loader subunits, C-terminal domain (From Topology)	T: DNA polymerase III clamp loader subunits, C-terminal domain	F: PF08542	ECOD (1.6)
A	PF21960	e2chvA6	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF21960	ECOD (1.6)
A	PF00004	e2chvA4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
B	PF08542	e2chvB5	A: alpha arrays	X: DNA polymerase III clamp loader subunits, C-terminal domain (From Topology)	H: DNA polymerase III clamp loader subunits, C-terminal domain (From Topology)	T: DNA polymerase III clamp loader subunits, C-terminal domain	F: PF08542	ECOD (1.6)
B	PF21960	e2chvB6	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF21960	ECOD (1.6)
B	PF00004	e2chvB4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
C	PF08542	e2chvC5	A: alpha arrays	X: DNA polymerase III clamp loader subunits, C-terminal domain (From Topology)	H: DNA polymerase III clamp loader subunits, C-terminal domain (From Topology)	T: DNA polymerase III clamp loader subunits, C-terminal domain	F: PF08542	ECOD (1.6)
C	PF21960	e2chvC6	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF21960	ECOD (1.6)
C	PF00004	e2chvC4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
D	PF08542	e2chvD5	A: alpha arrays	X: DNA polymerase III clamp loader subunits, C-terminal domain (From Topology)	H: DNA polymerase III clamp loader subunits, C-terminal domain (From Topology)	T: DNA polymerase III clamp loader subunits, C-terminal domain	F: PF08542	ECOD (1.6)
D	PF21960	e2chvD6	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF21960	ECOD (1.6)
D	PF00004	e2chvD4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
E	PF08542	e2chvE5	A: alpha arrays	X: DNA polymerase III clamp loader subunits, C-terminal domain (From Topology)	H: DNA polymerase III clamp loader subunits, C-terminal domain (From Topology)	T: DNA polymerase III clamp loader subunits, C-terminal domain	F: PF08542	ECOD (1.6)
E	PF21960	e2chvE6	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF21960	ECOD (1.6)
E	PF00004	e2chvE4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
F	PF08542	e2chvF5	A: alpha arrays	X: DNA polymerase III clamp loader subunits, C-terminal domain (From Topology)	H: DNA polymerase III clamp loader subunits, C-terminal domain (From Topology)	T: DNA polymerase III clamp loader subunits, C-terminal domain	F: PF08542	ECOD (1.6)
F	PF21960	e2chvF6	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF21960	ECOD (1.6)
F	PF00004	e2chvF4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A	1.10.8.60	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
A	1.20.272.10	Mainly Alpha	Up-down Bundle	Zinc Finger, Delta Prime	domain 3	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	1.10.8.60	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
B	1.20.272.10	Mainly Alpha	Up-down Bundle	Zinc Finger, Delta Prime	domain 3	CATH (4.3.0)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C	1.10.8.60	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
C	1.20.272.10	Mainly Alpha	Up-down Bundle	Zinc Finger, Delta Prime	domain 3	CATH (4.3.0)
D	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
D	1.10.8.60	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
D	1.20.272.10	Mainly Alpha	Up-down Bundle	Zinc Finger, Delta Prime	domain 3	CATH (4.3.0)
E	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
E	1.10.8.60	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
E	1.20.272.10	Mainly Alpha	Up-down Bundle	Zinc Finger, Delta Prime	domain 3	CATH (4.3.0)
F	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
F	1.10.8.60	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
F	1.20.272.10	Mainly Alpha	Up-down Bundle	Zinc Finger, Delta Prime	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF08542	Replication factor C C-terminal domain (Rep_fac_C)	Replication factor C C-terminal domain	This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which resul ...	This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A [1].	Domain
A, B, C, D, E A, B, C, D, E, F	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	REPLICATION FACTOR C SMALL SUBUNIT	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid DNA clamp loader activity catalytic activity ATP-dependent activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process	intracellular organelle protein-containing complex intracellular anatomical structure DNA replication factor C complex organelle intracellular non-membrane-bounded organelle replication fork chromosome cellular anatomical entity non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR008921	DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR013748	Replication factor C, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR047854	Replication factor C, lid domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR003593	AAA+ ATPase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR003959	ATPase, AAA-type, core	Domain
A, B, C, D, E A, B, C, D, E, F	IPR023748	Replication factor C small subunit, archaeal	Family
A, B, C, D, E A, B, C, D, E, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.