Annotations: 2CG9

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GHKL (Gyrase Hsp90 Histidine Kinase MutL) domain-like	8042891	3000091	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8042005	3000100	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	HSP90 middle pre-C-terminal domain	8056863	3002364	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HSP90 middle pre-C-terminal domain	8056863	3002364	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GHKL (Gyrase Hsp90 Histidine Kinase MutL) domain-like	8042891	3000091	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8042005	3000100	SCOP2B (2022-06-29)
C [auth X]	SCOP2 Family	Co-chaperone p23-like	8085070	4002443	SCOP2 (2022-06-29)
C [auth X]	SCOP2 Superfamily	Hsp20 chaperone-like	8085071	3001242	SCOP2 (2022-06-29)
D [auth Y]	SCOP2B Superfamily	Hsp20 chaperone-like	8085071	3001242	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HSP90_1st	e2cg9A4	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: HSP90_1st	ECOD (1.6)
A	HATPase_c	e2cg9A2	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: HATPase_c	ECOD (1.6)
A	HSP90_2nd	e2cg9A5	A: a/b three-layered sandwiches	X: HSP90 C-terminal a/b domain (From Topology)	H: HSP90 C-terminal a/b domain (From Topology)	T: HSP90 C-terminal a/b domain	F: HSP90_2nd	ECOD (1.6)
A	HSP90_3rd	e2cg9A6	A: mixed a+b and a/b	X: Zincin-like	H: HSP90 C-terminal domain (C-terminal part of Pfam 00183) (From Topology)	T: HSP90 C-terminal domain (C-terminal part of Pfam 00183)	F: HSP90_3rd	ECOD (1.6)
B	HSP90_1st	e2cg9B1	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: HSP90_1st	ECOD (1.6)
B	HATPase_c	e2cg9B2	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: HATPase_c	ECOD (1.6)
B	HSP90_2nd	e2cg9B6	A: a/b three-layered sandwiches	X: HSP90 C-terminal a/b domain (From Topology)	H: HSP90 C-terminal a/b domain (From Topology)	T: HSP90 C-terminal a/b domain	F: HSP90_2nd	ECOD (1.6)
B	HSP90_3rd	e2cg9B3	A: mixed a+b and a/b	X: Zincin-like	H: HSP90 C-terminal domain (C-terminal part of Pfam 00183) (From Topology)	T: HSP90 C-terminal domain (C-terminal part of Pfam 00183)	F: HSP90_3rd	ECOD (1.6)
C [auth X]	CS	e2cg9X1	A: beta sandwiches	X: HSP20-like	H: HSP20-like chaperones (From Topology)	T: HSP20-like chaperones	F: CS	ECOD (1.6)
D [auth Y]	CS	e2cg9Y1	A: beta sandwiches	X: HSP20-like	H: HSP20-like chaperones (From Topology)	T: HSP20-like chaperones	F: CS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.565.10	Alpha Beta	2-Layer Sandwich	Heat Shock Protein 90	Histidine kinase-like ATPase, C-terminal domain	CATH (4.3.0)
A	3.30.230.80	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
B	3.30.565.10	Alpha Beta	2-Layer Sandwich	Heat Shock Protein 90	Histidine kinase-like ATPase, C-terminal domain	CATH (4.3.0)
B	3.30.230.80	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
C [auth X]	2.60.40.790	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
D [auth Y]	2.60.40.790	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02518	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	Domain
A, B	PF00183	Hsp90 protein (HSP90)	Hsp90 protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	ATP-DEPENDENT MOLECULAR CHAPERONE HSP82	ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP-dependent protein folding chaperone protein folding chaperone ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding unfolded protein binding protein binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity identical protein binding	protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion establishment of protein localization to mitochondrion regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular response to stimulus cellular response to heat response to stimulus cellular response to stress response to stress response to heat response to abiotic stimulus response to temperature stimulus cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis response to oxygen levels regulation of telomere maintenance regulation of cellular component organization regulation of cellular process telomere organization regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process chromosome organization regulation of chromosome organization regulation of macromolecule metabolic process DNA metabolic process regulation of organelle organization nucleic acid metabolic process telomere maintenance organic cyclic compound metabolic process organelle organization regulation of metabolic process regulation of DNA metabolic process ribonucleoprotein complex biogenesis small nucleolar ribonucleoprotein complex assembly protein-RNA complex assembly protein-RNA complex organization box C/D snoRNP assembly positive regulation of organelle organization regulation of DNA biosynthetic process positive regulation of macromolecule biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening positive regulation of metabolic process positive regulation of telomere maintenance via telomere lengthening positive regulation of macromolecule metabolic process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process regulation of telomere maintenance via telomere lengthening positive regulation of chromosome organization positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process DNA biosynthetic process positive regulation of cellular component organization positive regulation of biological process positive regulation of cellular metabolic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of biosynthetic process telomere maintenance via telomerase positive regulation of DNA biosynthetic process nucleobase-containing compound biosynthetic process regulation of telomere maintenance via telomerase regulation of cellular biosynthetic process positive regulation of cellular biosynthetic process 'de novo' protein folding response to osmotic stress	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane protein-containing complex perinuclear region of cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
C [auth X], D [auth Y]	CO-CHAPERONE PROTEIN SBA1	Hsp90 protein binding protein binding binding heat shock protein binding protein-folding chaperone binding	regulation of molecular function regulation of DNA binding regulation of binding negative regulation of binding biological regulation negative regulation of molecular function negative regulation of DNA binding cellular component organization cellular component biogenesis cellular component assembly chaperone-mediated protein complex assembly protein-containing complex organization protein-containing complex assembly cellular process regulation of molecular function regulation of DNA binding regulation of binding negative regulation of binding biological regulation negative regulation of molecular function negative regulation of DNA binding cellular component organization cellular component biogenesis cellular component assembly chaperone-mediated protein complex assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis positive regulation of organelle organization regulation of cellular process telomere organization regulation of DNA biosynthetic process positive regulation of macromolecule biosynthetic process RNA-templated DNA biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening positive regulation of metabolic process organic substance biosynthetic process positive regulation of telomere maintenance via telomere lengthening positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process DNA metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization positive regulation of chromosome organization telomere maintenance organic cyclic compound metabolic process biosynthetic process positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process DNA biosynthetic process regulation of metabolic process regulation of DNA metabolic process regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of biosynthetic process telomere maintenance via telomerase chromosome organization positive regulation of DNA biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of telomere maintenance via telomerase regulation of cellular biosynthetic process organelle organization positive regulation of cellular biosynthetic process organonitrogen compound metabolic process gene expression protein maturation protein folding protein metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR003594	Histidine kinase/HSP90-like ATPase	Domain
A, B	IPR020575	Heat shock protein Hsp90, N-terminal	Domain
A, B	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A, B	IPR037196	HSP90, C-terminal domain	Homologous Superfamily
A, B	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
A, B	IPR001404	Heat shock protein Hsp90 family	Family
A, B	IPR019805	Heat shock protein Hsp90, conserved site	Conserved Site
C [auth X], D [auth Y]	IPR007052	CS domain	Domain
C [auth X], D [auth Y]	IPR045250	Co-chaperone protein p23-like	Family
C [auth X], D [auth Y]	IPR008978	HSP20-like chaperone	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.