Annotations: 2CF2

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2cf2a2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Beta-ketoacyl-ACP synthase I, C-terminal domain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
A	d2cf2a1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Beta-ketoacyl-ACP synthase I, N-terminal domain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
F [auth J]	d2cf2j2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Beta-ketoacyl-ACP synthase I, C-terminal domain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
F [auth J]	d2cf2j1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Thiolase-related	Beta-ketoacyl-ACP synthase I, N-terminal domain	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
C	d2cf2c1	Alpha and beta proteins (a+b)	Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	beta-Hydroxydecanol thiol ester dehydrase	beta-Hydroxydecanol thiol ester dehydrase	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
H [auth L]	d2cf2l1	Alpha and beta proteins (a+b)	Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	beta-Hydroxydecanol thiol ester dehydrase	beta-Hydroxydecanol thiol ester dehydrase	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
E	d2cf2e1	Low resolution protein structures	Fatty acid synthase	Fatty acid synthase	Fatty acid syntase	mammalian fatty acid synthase	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
J [auth N]	d2cf2n1	Low resolution protein structures	Fatty acid synthase	Fatty acid synthase	Fatty acid syntase	mammalian fatty acid synthase	(Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Thiolase-like	8037440	3000122	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Thiolase-like	8037437	3000122	SCOP2B (2022-06-29)
F [auth J]	SCOP2B Superfamily	Thiolase-like	8037440	3000122	SCOP2B (2022-06-29)
F [auth J]	SCOP2B Superfamily	Thiolase-like	8037437	3000122	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00109	e2cf2A1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00109	ECOD (1.6)
A	PF02801	e2cf2A2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02801	ECOD (1.6)
F [auth J]	PF00109	e2cf2J1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF00109	ECOD (1.6)
F [auth J]	PF02801	e2cf2J2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: PF02801	ECOD (1.6)
B	F_UNCLASSIFIED	e2cf2B1	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00698	e2cf2B2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF00698	ECOD (1.6)
G [auth K]	F_UNCLASSIFIED	e2cf2K1	A: a+b two layers	X: Alpha-beta plaits	H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)	T: Probable ACP-binding domain of malonyl-CoA ACP transacylase	F: F_UNCLASSIFIED	ECOD (1.6)
G [auth K]	PF00698	e2cf2K2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: FabD/lysophospholipase-like	F: PF00698	ECOD (1.6)
C	PF07977	e2cf2C1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF07977	ECOD (1.6)
H [auth L]	PF07977	e2cf2L1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PF07977	ECOD (1.6)
D	PF08240,PF13602	e2cf2D1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240,PF13602	ECOD (1.6)
D	PF00107	e2cf2D2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
I [auth M]	PF08240,PF13602	e2cf2M1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: PF08240,PF13602	ECOD (1.6)
I [auth M]	PF00107	e2cf2M2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00107	ECOD (1.6)
E	PF13561	e2cf2E1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)
J [auth N]	PF13561	e2cf2N1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF13561	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, F [auth J]	PF02801	Beta-ketoacyl synthase, C-terminal domain (Ketoacyl-synt_C)	Beta-ketoacyl synthase, C-terminal domain	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.	Domain
A, F [auth J]	PF00109	Beta-ketoacyl synthase, N-terminal domain (ketoacyl-synt)	Beta-ketoacyl synthase, N-terminal domain	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains m ...	The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains most of the structures involved in dimer formation and also the active site cysteine [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, F [auth J]	FATTY ACID SYNTHASE, KS DOMAIN	acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity	oxoacid metabolic process cellular biosynthetic process lipid biosynthetic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process small molecule metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process oxoacid metabolic process cellular biosynthetic process lipid biosynthetic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process small molecule metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process primary metabolic process fatty acid biosynthetic process monounsaturated fatty acid biosynthetic process biosynthetic process cellular lipid metabolic process monounsaturated fatty acid metabolic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol
B, G [auth K]	FATTY ACID SYNTHASE, MAT DOMAIN	-	-	-
C, H [auth L]	FATTY ACID SYNTHASE, DH DOMAIN	-	-	-
D, I [auth M]	FATTY ACID SYNTHASE, ER DOMAIN	-	-	-
E, J [auth N]	FATTY ACID SYNTHASE, KR DOMAIN	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, F [auth J]	IPR016039	Thiolase-like	Homologous Superfamily
A, F [auth J]	IPR014031	Beta-ketoacyl synthase, C-terminal	Domain
A, F [auth J]	IPR000794	Beta-ketoacyl synthase	Family
A, F [auth J]	IPR018201	Beta-ketoacyl synthase, active site	Active Site
A, F [auth J]	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	Domain
A, F [auth J]	IPR014030	Beta-ketoacyl synthase, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.