2C58

Torpedo californica acetylcholinesterase in complex with 20mM acetylthiocholine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2c58a_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Acetylcholinesterase-like	Acetylcholinesterase	(Tetronarce californica ) [TaxId: 7787 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	alpha/beta-Hydrolases	8032473	3000102	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	COesterase	e2c58A1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: COesterase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00135	Carboxylesterase family (COesterase)	Carboxylesterase family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ACETYLCHOLINESTERASE	acetylcholinesterase activity hydrolase activity, acting on ester bonds cholinesterase activity carboxylic ester hydrolase activity hydrolase activity catalytic activity	trans-synaptic signaling acetate ester metabolic process regulation of biological process catabolic process signaling biological regulation cell-cell signaling acetylcholine catabolic process in synaptic cleft chemical synaptic transmission cell communication synaptic signaling organic substance metabolic process anterograde trans-synaptic signaling synaptic transmission, cholinergic trans-synaptic signaling acetate ester metabolic process regulation of biological process catabolic process signaling biological regulation cell-cell signaling acetylcholine catabolic process in synaptic cleft chemical synaptic transmission cell communication synaptic signaling organic substance metabolic process anterograde trans-synaptic signaling synaptic transmission, cholinergic acetylcholine catabolic process acetylcholine metabolic process cellular process metabolic process organic substance catabolic process	membrane cellular anatomical entity side of membrane cell periphery plasma membrane synaptic cleft extracellular region synapse cell junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019819	Carboxylesterase type B, conserved site	Conserved Site
A	IPR019826	Carboxylesterase type B, active site	Active Site
A	IPR000908	Acetylcholinesterase, fish/snake	Family
A	IPR000997	Cholinesterase	Family
A	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
A	IPR002018	Carboxylesterase, type B	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	OAS	Parent Component: SER RESID: AA0364 PSI-MOD : O-acetyl-L-serine MOD:00369 , N,O-diacetylated L-serine MOD:00648

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.