2C45

NATIVE PRECURSOR OF PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Pyruvoyl dependent aspartate decarboxylase ADC	8074907	4002353	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ADC-like	8074908	3001132	SCOP2 (2022-06-29)
E	SCOP2B Superfamily	ADC-like	8074908	3001132	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ADC-like	8074908	3001132	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ADC-like	8074908	3001132	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ADC-like	8074908	3001132	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ADC-like	8074908	3001132	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	ADC-like	8074908	3001132	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	ADC-like	8074908	3001132	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Asp_decarbox	e2c45A1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Asp_decarbox	ECOD (1.6)
E	Asp_decarbox	e2c45E1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Asp_decarbox	ECOD (1.6)
F	Asp_decarbox	e2c45F1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Asp_decarbox	ECOD (1.6)
B	Asp_decarbox	e2c45B1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Asp_decarbox	ECOD (1.6)
C	Asp_decarbox	e2c45C1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Asp_decarbox	ECOD (1.6)
D	Asp_decarbox	e2c45D1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Asp_decarbox	ECOD (1.6)
G	Asp_decarbox	e2c45G1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Asp_decarbox	ECOD (1.6)
H	Asp_decarbox	e2c45H1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Asp_decarbox	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.40.20	Mainly Beta	Beta Barrel	Barwin-like endoglucanases		CATH (4.3.0)
E	2.40.40.20	Mainly Beta	Beta Barrel	Barwin-like endoglucanases		CATH (4.3.0)
F	2.40.40.20	Mainly Beta	Beta Barrel	Barwin-like endoglucanases		CATH (4.3.0)
B	2.40.40.20	Mainly Beta	Beta Barrel	Barwin-like endoglucanases		CATH (4.3.0)
C	2.40.40.20	Mainly Beta	Beta Barrel	Barwin-like endoglucanases		CATH (4.3.0)
D	2.40.40.20	Mainly Beta	Beta Barrel	Barwin-like endoglucanases		CATH (4.3.0)
G	2.40.40.20	Mainly Beta	Beta Barrel	Barwin-like endoglucanases		CATH (4.3.0)
H	2.40.40.20	Mainly Beta	Beta Barrel	Barwin-like endoglucanases		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF02261	Aspartate decarboxylase (Asp_decarbox)	Aspartate decarboxylase	Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalysed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesised initially as a proenzyme w ...	Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalysed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesised initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Aspartate 1-decarboxylase	aspartate 1-decarboxylase activity carboxy-lyase activity lyase activity catalytic activity carbon-carbon lyase activity	oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process vitamin biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process small molecule metabolic process amide metabolic process water-soluble vitamin metabolic process pantothenate metabolic process organonitrogen compound metabolic process oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process vitamin biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process small molecule metabolic process amide metabolic process water-soluble vitamin metabolic process pantothenate metabolic process organonitrogen compound metabolic process water-soluble vitamin biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process amide biosynthetic process vitamin metabolic process cellular modified amino acid metabolic process biosynthetic process cellular modified amino acid biosynthetic process pantothenate biosynthetic process metabolic process cellular process monocarboxylic acid metabolic process amino acid metabolic process alpha-amino acid metabolic process alanine biosynthetic process primary metabolic process amino acid biosynthetic process alanine metabolic process alpha-amino acid biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery external encapsulating structure cell wall peptidoglycan-based cell wall

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR003190	Aspartate decarboxylase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR009010	Aspartate decarboxylase-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.