2BZD

Galactose recognition by the carbohydrate-binding module of a bacterial sialidase.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2bzda2	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	automated matches	automated matches	(Micromonospora viridifaciens ) [TaxId: 1881 ],	SCOPe (2.08)
A	d2bzda3	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	automated matches	automated matches	(Micromonospora viridifaciens ) [TaxId: 1881 ],	SCOPe (2.08)
A	d2bzda1	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	automated matches	(Micromonospora viridifaciens ) [TaxId: 1881 ],	SCOPe (2.08)
B	d2bzdb2	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	automated matches	automated matches	(Micromonospora viridifaciens ) [TaxId: 1881 ],	SCOPe (2.08)
B	d2bzdb3	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	automated matches	automated matches	(Micromonospora viridifaciens ) [TaxId: 1881 ],	SCOPe (2.08)
B	d2bzdb1	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	automated matches	(Micromonospora viridifaciens ) [TaxId: 1881 ],	SCOPe (2.08)
C	d2bzdc2	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	automated matches	automated matches	(Micromonospora viridifaciens ) [TaxId: 1881 ],	SCOPe (2.08)
C	d2bzdc3	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	automated matches	automated matches	(Micromonospora viridifaciens ) [TaxId: 1881 ],	SCOPe (2.08)
C	d2bzdc1	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	automated matches	(Micromonospora viridifaciens ) [TaxId: 1881 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	E set domains	8054893	3000070	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Sialidases	8043344	3001607	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	galactose-binding domain-like	8043343	3000087	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	galactose-binding domain-like	8043343	3000087	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Sialidases	8043344	3001607	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	E set domains	8054893	3000070	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Sialidases	8043344	3001607	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	galactose-binding domain-like	8043343	3000087	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	E set domains	8054893	3000070	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00754	e2bzdA1	A: beta sandwiches	X: jelly-roll	H: Galactose-binding domain-like (From Topology)	T: Galactose-binding domain-like	F: PF00754	ECOD (1.6)
A	PF10633	e2bzdA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF10633	ECOD (1.6)
A	PF13088	e2bzdA3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF13088	ECOD (1.6)
B	PF00754	e2bzdB1	A: beta sandwiches	X: jelly-roll	H: Galactose-binding domain-like (From Topology)	T: Galactose-binding domain-like	F: PF00754	ECOD (1.6)
B	PF10633	e2bzdB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF10633	ECOD (1.6)
B	PF13088	e2bzdB3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF13088	ECOD (1.6)
C	PF00754	e2bzdC1	A: beta sandwiches	X: jelly-roll	H: Galactose-binding domain-like (From Topology)	T: Galactose-binding domain-like	F: PF00754	ECOD (1.6)
C	PF10633	e2bzdC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF10633	ECOD (1.6)
C	PF13088	e2bzdC3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF13088	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
A	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
B	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
C	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00754	F5/8 type C domain (F5_F8_type_C)	F5/8 type C domain	This domain is also known as the discoidin (DS) domain family [1].	Domain
A, B, C	PF13088	BNR repeat-like domain (BNR_2)	BNR repeat-like domain	-	Repeat
A, B, C	PF10633	NPCBM-associated, NEW3 domain of alpha-galactosidase (NPCBM_assoc)	NPCBM-associated, NEW3 domain of alpha-galactosidase	The English-language version of the first reference can be found on pages 388-399 of the above. This domain has been named NEW3 but its actual function is not known. It is found on proteins which are bacterial galactosidases [1]. The domain is associ ...	The English-language version of the first reference can be found on pages 388-399 of the above. This domain has been named NEW3 but its actual function is not known. It is found on proteins which are bacterial galactosidases [1]. The domain is associated with the NPCBM family, Pfam:PF08305, a novel putative carbohydrate binding module found at the N-terminus of glycosyl hydrolases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	BACTERIAL SIALIDASE	hydrolase activity, acting on glycosyl bonds exo-alpha-(2->6)-sialidase activity alpha-sialidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity exo-alpha-sialidase activity catalytic activity exo-alpha-(2->8)-sialidase activity exo-alpha-(2->3)-sialidase activity	carbohydrate metabolic process organic substance metabolic process primary metabolic process metabolic process	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR018905	Alpha-galactosidase, NEW3 domain	Domain
A, B, C	IPR006311	Twin-arginine translocation pathway, signal sequence	Conserved Site
A, B, C	IPR011040	Sialidase	Domain
A, B, C	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A, B, C	IPR036278	Sialidase superfamily	Homologous Superfamily
A, B, C	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A, B, C	IPR026856	Sialidase family	Family
A, B, C	IPR000421	Coagulation factor 5/8 C-terminal domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.