2BYG

2nd PDZ Domain of Discs Large Homologue 2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2byga1	All beta proteins	PDZ domain-like	PDZ domain-like	PDZ domain	Channel associated protein of synapse-110	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2byga2	Artifacts	Tags	Tags	Tags	N-terminal Tags	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PDZ domain	8026511	4001790	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PDZ domain-like	8038890	3000388	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDZ	e2bygA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain
A	PF10600	PDZ-associated domain of NMDA receptors (PDZ_assoc)	PDZ-associated domain of NMDA receptors	This domain is found in higher eukaryotes between the second and third PDZ domains, Pfam:PF00595, of glutamate receptor like proteins. Its exact function is not known.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CHANNEL ASSOCIATED PROTEIN OF SYNAPSE-110	nucleobase-containing compound kinase activity nucleoside monophosphate kinase activity kinase activity transferase activity guanylate kinase activity catalytic activity phosphotransferase activity, phosphate group as acceptor transferase activity, transferring phosphorus-containing groups protein binding binding kinase binding enzyme binding	protein localization establishment of protein localization cellular localization nitrogen compound transport protein localization to synapse transport protein transport along microtubule microtubule-based protein transport localization cellular macromolecule localization establishment of localization in cell transport along microtubule anterograde axonal transport organic substance transport protein localization establishment of protein localization cellular localization nitrogen compound transport protein localization to synapse transport protein transport along microtubule microtubule-based protein transport localization cellular macromolecule localization establishment of localization in cell transport along microtubule anterograde axonal transport organic substance transport axo-dendritic protein transport anterograde axonal protein transport intracellular transport axonal transport establishment of localization protein localization to presynapse axo-dendritic transport protein transport macromolecule localization microtubule-based transport cellular process microtubule-based process cytoskeleton-dependent intracellular transport microtubule-based movement protein localization to cell junction intracellular protein transport cellular response to stimulus cellular response to inorganic substance cellular response to metal ion response to stimulus response to potassium ion response to inorganic substance cellular response to chemical stimulus response to metal ion response to chemical cellular response to potassium ion receptor localization to synapse protein-containing complex localization retrograde axonal protein transport retrograde axonal transport trans-synaptic signaling synaptic signaling regulation of biological process signaling anterograde trans-synaptic signaling biological regulation cell-cell signaling chemical synaptic transmission cell communication cell adhesion cell-cell adhesion receptor clustering localization within membrane protein localization to membrane establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment or maintenance of apical/basal cell polarity establishment or maintenance of cell polarity	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region axon cell projection main axon juxtaparanode region of axon neuron projection plasma membrane bounded cell projection somatodendritic compartment cell body perikaryon neuronal cell body intracellular anatomical structure cytoplasm cytosol basal part of cell basal plasma membrane basolateral plasma membrane cell-cell junction adherens junction anchoring junction neuromuscular junction neuron projection cytoplasm axon cytoplasm cytoplasmic region plasma membrane bounded cell projection cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR020590	Guanylate kinase, conserved site	Conserved Site
A	IPR019583	Disks large homolog 1-4, PDZ-associated domain	Domain
A	IPR016313	Disks large 1-like	Family
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR035759	Disks Large homologue 2, SH3 domain	Domain
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR001452	SH3 domain	Domain
A	IPR019590	Disks large homologue 1, N-terminal PEST domain	Domain
A	IPR008144	Guanylate kinase-like domain	Domain
A	IPR001478	PDZ domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q15700	melanoma kidney Wilms tumor malignant glioma oligodendroglioma primitive neuroectodermal tumor Schizophrenia and related disorders adenoma astrocytic tumor bipolar disorder glioblastoma interstitial cystitis large cell medulloblastoma major depressive disorder medulloblastoma Perlman syndrome melanoma kidney Wilms tumor malignant glioma oligodendroglioma primitive neuroectodermal tumor Schizophrenia and related disorders adenoma astrocytic tumor bipolar disorder glioblastoma interstitial cystitis large cell medulloblastoma major depressive disorder medulloblastoma Perlman syndrome psoriasis subependymal giant cell astrocytoma adrenal cortex carcinoma attention deficit hyperactivity disorder, inattentive type cutaneous lupus erythematosus hereditary Wilms tumor interstitial lung disease lung cancer malignant ependymoma pilocytic astrocytoma schizophrenia swine influenza anorexia nervosa atypical teratoid rhabdoid tumor cutaneous melanoma intellectual disability lung carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.