Annotations: 2BX2

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth L]	SCOP2 Family	Type III KH domain-like	8102256	4007825	SCOP2 (2022-06-29)
A [auth L]	SCOP2 Family	RNase E 5'-sensor domain-like	8102248	4007821	SCOP2 (2022-06-29)
A [auth L]	SCOP2 Family	Cold shock DNA-binding domain-like	8027222	4001909	SCOP2 (2022-06-29)
A [auth L]	SCOP2 Family	RNase E 'split' domain-like	8102250	4007822	SCOP2 (2022-06-29)
A [auth L]	SCOP2 Family	RNase E 'linker' domain-like	8102254	4007824	SCOP2 (2022-06-29)
A [auth L]	SCOP2 Family	RNase E 'half' domain-like	8102252	4007823	SCOP2 (2022-06-29)
A [auth L]	SCOP2 Superfamily	Type III KH-domain	8102257	3002727	SCOP2 (2022-06-29)
A [auth L]	SCOP2 Superfamily	Ribosomal protein S5 domain 2-like	8102249	3000100	SCOP2 (2022-06-29)
A [auth L]	SCOP2 Superfamily	Nucleic acid-binding proteins	8039601	3000135	SCOP2 (2022-06-29)
A [auth L]	SCOP2 Superfamily	Ribonuclease H-like	8102251	3000143	SCOP2 (2022-06-29)
A [auth L]	SCOP2 Superfamily	DnaJ/Hsp40 cysteine-rich domain-like	8102255	3001550	SCOP2 (2022-06-29)
A [auth L]	SCOP2 Superfamily	MK0968-like	8102253	3002481	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth L]	S1_4	e2bx2L1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: S1_4	ECOD (1.6)
A [auth L]	RNase_E_G_1st	e2bx2L4	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_E_G_1st	ECOD (1.6)
A [auth L]	rne	e2bx2L5	A: a+b three layers	X: Thioredoxin-like domain in RNase E (From Topology)	H: Thioredoxin-like domain in RNase E (From Topology)	T: Thioredoxin-like domain in RNase E	F: rne	ECOD (1.6)
A [auth L]	RNase_E_G_3rd	e2bx2L3	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: RNase_E_G_3rd	ECOD (1.6)
A [auth L]	RNase_E_G_2nd	e2bx2L2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: RNase_E_G_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth L]	3.40.1260.20	Alpha Beta	3-Layer(aba) Sandwich	Hypothetical Protein Ychn	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth L]	PF20833	RNase E/G, Thioredoxin-like domain (RNase_E_G_Thio)	RNase E/G, Thioredoxin-like domain	Both RNase E and its homologue RNase G are endoribonucleases that play central roles in RNA processing. RNase E shows two globular domains. This entry represents the smaller domain, which shows a thioredoxin-like fold [1-3].	Domain
A [auth L]	PF10150	Ribonuclease E/G family (RNase_E_G)	Ribonuclease E/G family	-	Family
A [auth L]	PF00575	S1 RNA binding domain (S1)	S1 RNA binding domain	The S1 domain occurs in a wide range of RNA associated proteins. It is structurally similar to cold shock protein which binds nucleic acids. The S1 domain has an OB-fold structure.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth L]	RIBONUCLEASE E	RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding tRNA binding cation binding magnesium ion binding ion binding metal ion binding small molecule binding 7S RNA binding ribonuclease E activity nuclease activity RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding tRNA binding cation binding magnesium ion binding ion binding metal ion binding small molecule binding 7S RNA binding ribonuclease E activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity endonuclease activity RNA endonuclease activity protein binding enzyme binding DEAD/H-box RNA helicase binding molecular adaptor activity transition metal ion binding zinc ion binding identical protein binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein homotetramerization protein tetramerization protein homooligomerization ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein homotetramerization protein tetramerization protein homooligomerization ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing nucleobase-containing compound metabolic process ribosome biogenesis organic substance metabolic process organic substance biosynthetic process RNA processing rRNA metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process tRNA metabolic process tRNA processing catabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process organic substance catabolic process RNA catabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process regulation of biological process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process mRNA metabolic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process regulation of helicase activity regulation of ATP-dependent activity regulation of molecular function regulation of RNA helicase activity regulation of catalytic activity rRNA 5'-end processing RNA 5'-end processing	membrane cellular anatomical entity bacterial degradosome exosome (RNase complex) protein-containing complex intracellular anatomical structure catalytic complex cytoplasm cytosol cytoplasmic exosome (RNase complex) exoribonuclease complex endoribonuclease complex intracellular protein-containing complex endonuclease complex membrane cellular anatomical entity bacterial degradosome exosome (RNase complex) protein-containing complex intracellular anatomical structure catalytic complex cytoplasm cytosol cytoplasmic exosome (RNase complex) exoribonuclease complex endoribonuclease complex intracellular protein-containing complex endonuclease complex cell periphery cytoplasmic side of plasma membrane cytoplasmic side of membrane plasma membrane side of membrane
B [auth R]	RNA (5'-R(UPUPUPAPCPAPGPUPAPUPUP UPGPUP*U)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth L]	IPR028878	Ribonuclease E	Family
A [auth L]	IPR004659	Ribonuclease E/G	Family
A [auth L]	IPR003029	S1 domain	Domain
A [auth L]	IPR019307	RNA-binding protein AU-1/Ribonuclease E/G	Family
A [auth L]	IPR021968	Polyribonucleotide phosphorylase C-terminal	Domain
A [auth L]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A [auth L]	IPR048583	RNase E/G, thioredoxin-like domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.