2BR2

RNase PH core of the archaeal exosome

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2br2a1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
A	d2br2a2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	automated matches	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
C	d2br2c1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
C	d2br2c2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	automated matches	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
E	d2br2e1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
E	d2br2e2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	automated matches	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
G	d2br2g1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
G	d2br2g2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	automated matches	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
I	d2br2i1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
I	d2br2i2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	automated matches	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
K	d2br2k1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
K	d2br2k2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	automated matches	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
M	d2br2m1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
M	d2br2m2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	automated matches	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
O	d2br2o1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
O	d2br2o2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	automated matches	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
Q	d2br2q1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
Q	d2br2q2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	automated matches	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
S	d2br2s1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
S	d2br2s2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	automated matches	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
U	d2br2u1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
U	d2br2u2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	automated matches	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
W	d2br2w1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
W	d2br2w2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	automated matches	automated matches	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
B	d2br2b1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
B	d2br2b2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
D	d2br2d1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
D	d2br2d2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
F	d2br2f1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
F	d2br2f2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
H	d2br2h1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
H	d2br2h2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
J	d2br2j1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
J	d2br2j2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
L	d2br2l1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
L	d2br2l2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
N	d2br2n1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
N	d2br2n2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
P	d2br2p1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
P	d2br2p2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
R	d2br2r1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
R	d2br2r2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
T	d2br2t1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
T	d2br2t2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
V	d2br2v1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
V	d2br2v2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
X	d2br2x1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)
X	d2br2x2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Saccharolobus solfataricus ) [TaxId: 2287 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034675	3000346	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034673	3000100	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034675	3000346	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034673	3000100	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034675	3000346	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034673	3000100	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034675	3000346	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034673	3000100	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034675	3000346	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034673	3000100	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034673	3000100	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034675	3000346	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034673	3000100	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034675	3000346	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034675	3000346	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034673	3000100	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034673	3000100	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034675	3000346	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034675	3000346	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034673	3000100	SCOP2B (2022-06-29)
U	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034675	3000346	SCOP2B (2022-06-29)
U	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034673	3000100	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034673	3000100	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034675	3000346	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034677	3000100	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034679	3000346	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034679	3000346	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034677	3000100	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034677	3000100	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034679	3000346	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034679	3000346	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034677	3000100	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034677	3000100	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034679	3000346	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034679	3000346	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034677	3000100	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034679	3000346	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034677	3000100	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034677	3000100	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034679	3000346	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034679	3000346	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034677	3000100	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034679	3000346	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034677	3000100	SCOP2B (2022-06-29)
V	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034679	3000346	SCOP2B (2022-06-29)
V	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034677	3000100	SCOP2B (2022-06-29)
X	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8034677	3000100	SCOP2B (2022-06-29)
X	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8034679	3000346	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RNase_PH_2	e2br2A2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
A	RNase_PH_C_1	e2br2A1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
C	RNase_PH_2	e2br2C2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
C	RNase_PH_C_1	e2br2C1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
E	RNase_PH_2	e2br2E2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
E	RNase_PH_C_1	e2br2E1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
G	RNase_PH_2	e2br2G2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
G	RNase_PH_C_1	e2br2G1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
I	RNase_PH_2	e2br2I2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
I	RNase_PH_C_1	e2br2I1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
K	RNase_PH_2	e2br2K2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
K	RNase_PH_C_1	e2br2K1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
M	RNase_PH_2	e2br2M2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
M	RNase_PH_C_1	e2br2M1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
O	RNase_PH_2	e2br2O2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
O	RNase_PH_C_1	e2br2O1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
Q	RNase_PH_2	e2br2Q2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
Q	RNase_PH_C_1	e2br2Q1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
S	RNase_PH_2	e2br2S2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
S	RNase_PH_C_1	e2br2S1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
U	RNase_PH_2	e2br2U2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
U	RNase_PH_C_1	e2br2U1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
W	RNase_PH_2	e2br2W2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
W	RNase_PH_C_1	e2br2W1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
B	RNase_PH	e2br2B2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
B	RNase_PH_C_3	e2br2B1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)
D	RNase_PH	e2br2D2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
D	RNase_PH_C_3	e2br2D1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)
F	RNase_PH	e2br2F2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
F	RNase_PH_C_3	e2br2F1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)
H	RNase_PH	e2br2H2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
H	RNase_PH_C_3	e2br2H1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)
J	RNase_PH	e2br2J2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
J	RNase_PH_C_3	e2br2J1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)
L	RNase_PH	e2br2L2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
L	RNase_PH_C_3	e2br2L1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)
N	RNase_PH	e2br2N2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
N	RNase_PH_C_3	e2br2N1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)
P	RNase_PH	e2br2P2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
P	RNase_PH_C_3	e2br2P1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)
R	RNase_PH	e2br2R2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
R	RNase_PH_C_3	e2br2R1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)
T	RNase_PH	e2br2T2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
T	RNase_PH_C_3	e2br2T1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)
V	RNase_PH	e2br2V2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
V	RNase_PH_C_3	e2br2V1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)
X	RNase_PH	e2br2X2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
X	RNase_PH_C_3	e2br2X1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
C	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
E	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
G	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
I	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
K	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
M	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
O	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
Q	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
S	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
U	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
W	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
B	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
D	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
F	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
H	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
J	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
L	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
N	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
P	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
R	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
T	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
V	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
X	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	PF03725	3' exoribonuclease family, domain 2 (RNase_PH_C)	3' exoribonuclease family, domain 2	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of ...	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.	Domain
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	PF01138	3' exoribonuclease family, domain 1 (RNase_PH)	3' exoribonuclease family, domain 1	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of ...	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.	Domain
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	PF03725	3' exoribonuclease family, domain 2 (RNase_PH_C)	3' exoribonuclease family, domain 2	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of ...	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.	Domain
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	PF01138	3' exoribonuclease family, domain 1 (RNase_PH)	3' exoribonuclease family, domain 1	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of ...	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	EXOSOME COMPLEX EXONUCLEASE 2	-	catabolic process RNA metabolic process primary metabolic process rRNA catabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process ncRNA metabolic process nucleic acid catabolic process metabolic process catabolic process RNA metabolic process primary metabolic process rRNA catabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process ncRNA metabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process rRNA metabolic process organic substance catabolic process RNA catabolic process	exosome (RNase complex) protein-containing complex intracellular anatomical structure catalytic complex cytoplasm cellular anatomical entity cytoplasmic exosome (RNase complex) exoribonuclease complex
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	EXOSOME COMPLEX EXONUCLEASE 1	3'-5'-RNA exonuclease activity catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity RNA exonuclease activity RNA nuclease activity hydrolase activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds exonuclease activity catalytic activity	catabolic process RNA metabolic process primary metabolic process rRNA catabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process ncRNA metabolic process nucleic acid catabolic process metabolic process catabolic process RNA metabolic process primary metabolic process rRNA catabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process ncRNA metabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process rRNA metabolic process organic substance catabolic process RNA catabolic process	exosome (RNase complex) protein-containing complex intracellular anatomical structure catalytic complex cytoplasm cellular anatomical entity cytoplasmic exosome (RNase complex) exoribonuclease complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	IPR027408	PNPase/RNase PH domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	IPR001247	Exoribonuclease, phosphorolytic domain 1	Domain
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	IPR036345	Exoribonuclease, PH domain 2 superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	IPR015847	Exoribonuclease, phosphorolytic domain 2	Domain
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	IPR020869	Exosome complex component Rrp42, archaea	Family
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	IPR011807	Exosome complex component Rrp41	Family
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	IPR027408	PNPase/RNase PH domain superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	IPR001247	Exoribonuclease, phosphorolytic domain 1	Domain
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	IPR036345	Exoribonuclease, PH domain 2 superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	IPR015847	Exoribonuclease, phosphorolytic domain 2	Domain