Annotations: 2BOU

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e2bouA3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF07645	e2bouA1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: PF07645	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07645	Calcium-binding EGF domain (EGF_CA)	Calcium-binding EGF domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	EGF-LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2 PRECURSOR	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity glycosaminoglycan binding chondroitin sulfate binding carbohydrate derivative binding sulfur compound binding	response to stimulus immune response immune system process regulation of biological process signaling biological regulation cell-cell signaling cellular process cell communication cellular response to stimulus regulation of cellular process adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway response to stimulus immune response immune system process regulation of biological process signaling biological regulation cell-cell signaling cellular process cell communication cellular response to stimulus regulation of cellular process adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction cell surface receptor signaling pathway cell adhesion defense response response to stress inflammatory response cell chemotaxis chemotaxis response to external stimulus granulocyte migration leukocyte migration cellular response to chemical stimulus taxis granulocyte chemotaxis response to chemical myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion establishment of organelle localization regulation of immune effector process regulation of localization multicellular organismal process regulation of myeloid leukocyte mediated immunity regulated exocytosis cell activation involved in immune response leukocyte degranulation myeloid leukocyte mediated immunity vesicle-mediated transport myeloid leukocyte activation localization establishment of localization in cell leukocyte mediated immunity regulation of immune system process vacuolar localization establishment of localization mast cell degranulation immune effector process regulation of secretion regulation of leukocyte mediated immunity exocytosis lysosome localization cellular localization transport regulation of mast cell degranulation leukocyte activation regulation of regulated secretory pathway secretion by cell regulation of secretion by cell organelle localization leukocyte activation involved in immune response mast cell activation regulation of leukocyte degranulation mast cell mediated immunity secretion regulation of transport cell activation export from cell regulation of vesicle-mediated transport myeloid cell activation involved in immune response mast cell activation involved in immune response regulation of exocytosis	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle cytoplasm organelle membrane secretory granule membrane ruffle cell leading edge leading edge membrane plasma membrane bounded cell projection cell projection ruffle membrane plasma membrane region cell projection membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017983	GPCR, family 2, secretin-like, conserved site	Conserved Site
A	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
A	IPR003056	GPCR, family 2, ADGRE2/ADGRE5	Family
A	IPR000832	GPCR, family 2, secretin-like	Family
A	IPR000203	GPS motif	Conserved Site
A	IPR000742	EGF-like domain	Domain
A	IPR017981	GPCR, family 2-like, 7TM	Domain
A	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A	IPR001881	EGF-like calcium-binding domain	Domain
A	IPR046338	GAIN domain superfamily	Homologous Superfamily
A	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM
A	IPR017983	GPCR, family 2, secretin-like, conserved site	Conserved Site
A	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
A	IPR003056	GPCR, family 2, ADGRE2/ADGRE5	Family
A	IPR000832	GPCR, family 2, secretin-like	Family
A	IPR000203	GPS motif	Conserved Site
A	IPR000742	EGF-like domain	Domain
A	IPR017981	GPCR, family 2-like, 7TM	Domain
A	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A	IPR001881	EGF-like calcium-binding domain	Domain
A	IPR046338	GAIN domain superfamily	Homologous Superfamily
A	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UHX3	acute myeloid leukemia exocrine pancreatic carcinoma interstitial cystitis lung disease MALT lymphoma pancreatic ductal adenocarcinoma pilocytic astrocytoma Barrett esophagus gastric carcinoma lung adenocarcinoma Lung diseases nephrolithiasis pancreatic intraductal papillary-mucinous carcinoma psoriasis esophageal adenocarcinoma acute myeloid leukemia exocrine pancreatic carcinoma interstitial cystitis lung disease MALT lymphoma pancreatic ductal adenocarcinoma pilocytic astrocytoma Barrett esophagus gastric carcinoma lung adenocarcinoma Lung diseases nephrolithiasis pancreatic intraductal papillary-mucinous carcinoma psoriasis esophageal adenocarcinoma glioblastoma lung carcinoma malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm vibratory urticaria autosomal dominant vibratory urticaria familial dermatographia head and neck cancer malignant glioma breast cancer Familial dermographism interstitial cystitis ulcerative colitis chronic obstructive pulmonary disease glioblastoma lung carcinoma