2BJI

High Resolution Structure of myo-Inositol Monophosphatase, The Target of Lithium Therapy

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2bjia_	Multi-domain proteins (alpha and beta)	Carbohydrate phosphatase	Carbohydrate phosphatase	Inositol monophosphatase/fructose-1,6-bisphosphatase-like	automated matches	BOVINE (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d2bjib_	Multi-domain proteins (alpha and beta)	Carbohydrate phosphatase	Carbohydrate phosphatase	Inositol monophosphatase/fructose-1,6-bisphosphatase-like	automated matches	BOVINE (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Inositol monophosphatase/fructose-1 6-bisphosphatase-like	8079742	4002766	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Carbohydrate phosphatase-like	8079743	3001721	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Carbohydrate phosphatase-like	8079743	3001721	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Inositol_P_N	e2bjiA1	A: a+b two layers	X: a+b domain in carbohydrate phosphatases (From Topology)	H: a+b domain in carbohydrate phosphatases (From Topology)	T: a+b domain in carbohydrate phosphatases	F: Inositol_P_N	ECOD (1.6)
A	Inositol_P_C	e2bjiA2	A: a/b three-layered sandwiches	X: Rossmann-like domain in carbohydrate phosphatases (From Homology)	H: Rossmann-like domain in carbohydrate phosphatases	T: Rossmann-like domain in carbohydrate phosphatases	F: Inositol_P_C	ECOD (1.6)
B	Inositol_P_N	e2bjiB1	A: a+b two layers	X: a+b domain in carbohydrate phosphatases (From Topology)	H: a+b domain in carbohydrate phosphatases (From Topology)	T: a+b domain in carbohydrate phosphatases	F: Inositol_P_N	ECOD (1.6)
B	Inositol_P_C	e2bjiB2	A: a/b three-layered sandwiches	X: Rossmann-like domain in carbohydrate phosphatases (From Homology)	H: Rossmann-like domain in carbohydrate phosphatases	T: Rossmann-like domain in carbohydrate phosphatases	F: Inositol_P_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.540.10	Alpha Beta	2-Layer Sandwich	Fructose-1,6-Bisphosphatase	Chain A, domain 1	CATH (4.3.0)
A	3.40.190.80	Alpha Beta	3-Layer(aba) Sandwich	D-Maltodextrin-Binding Protein	domain 2	CATH (4.3.0)
B	3.30.540.10	Alpha Beta	2-Layer Sandwich	Fructose-1,6-Bisphosphatase	Chain A, domain 1	CATH (4.3.0)
B	3.40.190.80	Alpha Beta	3-Layer(aba) Sandwich	D-Maltodextrin-Binding Protein	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00459	Inositol monophosphatase family (Inositol_P)	Inositol monophosphatase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	INOSITOL-1(OR 4)-MONOPHOSPHATASE	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding phosphoric ester hydrolase activity inositol monophosphate phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds inositol monophosphate 4-phosphatase activity phosphatase activity hydrolase activity catalytic activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding phosphoric ester hydrolase activity inositol monophosphate phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds inositol monophosphate 4-phosphatase activity phosphatase activity hydrolase activity catalytic activity lithium ion binding alkali metal ion binding inositol monophosphate 1-phosphatase activity manganese ion binding transition metal ion binding inositol monophosphate 3-phosphatase activity	polyol metabolic process organic substance metabolic process inositol metabolic process organic hydroxy compound metabolic process alcohol metabolic process small molecule metabolic process metabolic process small molecule biosynthetic process inositol biosynthetic process biosynthetic process organic hydroxy compound biosynthetic process polyol biosynthetic process alcohol biosynthetic process organic substance biosynthetic process polyol metabolic process organic substance metabolic process inositol metabolic process organic hydroxy compound metabolic process alcohol metabolic process small molecule metabolic process metabolic process small molecule biosynthetic process inositol biosynthetic process biosynthetic process organic hydroxy compound biosynthetic process polyol biosynthetic process alcohol biosynthetic process organic substance biosynthetic process cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process cellular process glycerolipid metabolic process lipid metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction cell communication	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR033942	Inositol monophosphatase	Family
A, B	IPR020552	Inositol monophosphatase, lithium-sensitive	Family
A, B	IPR020550	Inositol monophosphatase, conserved site	Conserved Site
A, B	IPR020583	Inositol monophosphatase, metal-binding site	Binding Site
A, B	IPR000760	Inositol monophosphatase-like	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.