2BE7

Crystal structure of the unliganded (T-state) aspartate transcarbamoylase of the psychrophilic bacterium Moritella profunda

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2be7a1	Alpha and beta proteins (a/b)	ATC-like	Aspartate/ornithine carbamoyltransferase	Aspartate/ornithine carbamoyltransferase	Aspartate carbamoyltransferase catalytic subunit	(Moritella profunda ) [TaxId: 111291 ],	SCOPe (2.08)
B	d2be7b1	Alpha and beta proteins (a/b)	ATC-like	Aspartate/ornithine carbamoyltransferase	Aspartate/ornithine carbamoyltransferase	Aspartate carbamoyltransferase catalytic subunit	(Moritella profunda ) [TaxId: 111291 ],	SCOPe (2.08)
C	d2be7c1	Alpha and beta proteins (a/b)	ATC-like	Aspartate/ornithine carbamoyltransferase	Aspartate/ornithine carbamoyltransferase	Aspartate carbamoyltransferase catalytic subunit	(Moritella profunda ) [TaxId: 111291 ],	SCOPe (2.08)
D	d2be7d1	Alpha and beta proteins (a+b)	Ferredoxin-like	Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	Aspartate carbamoyltransferase	(Moritella profunda ) [TaxId: 111291 ],	SCOPe (2.08)
D	d2be7d2	Small proteins	Rubredoxin-like	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	(Moritella profunda ) [TaxId: 111291 ],	SCOPe (2.08)
E	d2be7e1	Alpha and beta proteins (a+b)	Ferredoxin-like	Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	Aspartate carbamoyltransferase	(Moritella profunda ) [TaxId: 111291 ],	SCOPe (2.08)
E	d2be7e2	Small proteins	Rubredoxin-like	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	(Moritella profunda ) [TaxId: 111291 ],	SCOPe (2.08)
F	d2be7f1	Alpha and beta proteins (a+b)	Ferredoxin-like	Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	Aspartate carbamoyltransferase	(Moritella profunda ) [TaxId: 111291 ],	SCOPe (2.08)
F	d2be7f2	Small proteins	Rubredoxin-like	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	(Moritella profunda ) [TaxId: 111291 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00185	e2be7A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: PF00185	ECOD (1.6)
A	PF02729	e2be7A2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: PF02729	ECOD (1.6)
B	PF00185	e2be7B1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: PF00185	ECOD (1.6)
B	PF02729	e2be7B2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: PF02729	ECOD (1.6)
C	PF00185	e2be7C1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: PF00185	ECOD (1.6)
C	PF02729	e2be7C2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: PF02729	ECOD (1.6)
D	PF01948	e2be7D1	A: a+b two layers	X: Alpha-beta plaits	H: Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain (From Topology)	T: Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	F: PF01948	ECOD (1.6)
D	PF02748	e2be7D2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	F: PF02748	ECOD (1.6)
E	PF01948	e2be7E1	A: a+b two layers	X: Alpha-beta plaits	H: Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain (From Topology)	T: Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	F: PF01948	ECOD (1.6)
E	PF02748	e2be7E2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	F: PF02748	ECOD (1.6)
F	PF01948	e2be7F4	A: a+b two layers	X: Alpha-beta plaits	H: Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain (From Topology)	T: Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain	F: PF01948	ECOD (1.6)
F	PF02748	e2be7F3	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain	F: PF02748	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Aspartate/ornithine carbamoyltransferase	CATH (4.3.0)
B	3.40.50.1370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Aspartate/ornithine carbamoyltransferase	CATH (4.3.0)
C	3.40.50.1370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Aspartate/ornithine carbamoyltransferase	CATH (4.3.0)
D	3.30.70.140	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Aspartate carbamoyltransferase regulatory subunit, N-terminal domain	CATH (4.3.0)
D	2.30.30.20	Mainly Beta	Roll	SH3 type barrels.	Aspartate carbamoyltransferase regulatory subunit, C-terminal domain	CATH (4.3.0)
E	3.30.70.140	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Aspartate carbamoyltransferase regulatory subunit, N-terminal domain	CATH (4.3.0)
E	2.30.30.20	Mainly Beta	Roll	SH3 type barrels.	Aspartate carbamoyltransferase regulatory subunit, C-terminal domain	CATH (4.3.0)
F	3.30.70.140	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Aspartate carbamoyltransferase regulatory subunit, N-terminal domain	CATH (4.3.0)
F	2.30.30.20	Mainly Beta	Roll	SH3 type barrels.	Aspartate carbamoyltransferase regulatory subunit, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF02729	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain (OTCace_N)	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain	-	Domain
A, B, C	PF00185	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain (OTCace)	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	-	Domain
D, E, F	PF02748	Aspartate carbamoyltransferase regulatory chain, metal binding domain (PyrI_C)	Aspartate carbamoyltransferase regulatory chain, metal binding domain	The regulatory chain is involved in allosteric regulation of aspartate carbamoyltransferase. The C-terminal metal binding domain has a rubredoxin-like fold and provides the interface with the catalytic chain.	Domain
D, E, F	PF01948	Aspartate carbamoyltransferase regulatory chain, allosteric domain (PyrI)	Aspartate carbamoyltransferase regulatory chain, allosteric domain	The regulatory chain is involved in allosteric regulation of aspartate carbamoyltransferase. The N-terminal domain has ferredoxin-like fold, and provides the regulatory chain dimerisation interface.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Aspartate Carbamoyltransferase Catalytic Chain	aspartate carbamoyltransferase activity carboxyl- or carbamoyltransferase activity transferase activity, transferring one-carbon groups transferase activity catalytic activity binding amino acid binding	organonitrogen compound metabolic process pyrimidine-containing compound metabolic process nucleobase biosynthetic process pyrimidine nucleobase biosynthetic process organonitrogen compound biosynthetic process primary metabolic process nucleobase-containing compound metabolic process pyrimidine nucleobase metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process nucleobase-containing small molecule metabolic process nucleobase metabolic process organic cyclic compound biosynthetic process organic substance biosynthetic process organonitrogen compound metabolic process pyrimidine-containing compound metabolic process nucleobase biosynthetic process pyrimidine nucleobase biosynthetic process organonitrogen compound biosynthetic process primary metabolic process nucleobase-containing compound metabolic process pyrimidine nucleobase metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process nucleobase-containing small molecule metabolic process nucleobase metabolic process organic cyclic compound biosynthetic process organic substance biosynthetic process 'de novo' pyrimidine nucleobase biosynthetic process small molecule metabolic process metabolic process pyrimidine-containing compound biosynthetic process ribose phosphate metabolic process nucleotide biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process 'de novo' UMP biosynthetic process ribonucleotide biosynthetic process UMP biosynthetic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process phosphate-containing compound metabolic process UMP metabolic process phosphorus metabolic process nucleoside monophosphate metabolic process ribose phosphate biosynthetic process pyrimidine ribonucleotide metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process pyrimidine nucleoside monophosphate metabolic process pyrimidine ribonucleoside monophosphate metabolic process cellular metabolic process nucleobase-containing compound biosynthetic process nucleotide metabolic process nucleoside monophosphate biosynthetic process pyrimidine ribonucleoside monophosphate biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process cellular process pyrimidine nucleoside monophosphate biosynthetic process ribonucleoside monophosphate biosynthetic process pyrimidine nucleotide biosynthetic process pyrimidine ribonucleotide biosynthetic process amino acid metabolic process	-
D, E, F	Aspartate Carbamoyltransferase Regulatory Chain	cation binding ion binding binding metal ion binding small molecule binding	organonitrogen compound metabolic process pyrimidine-containing compound metabolic process nucleobase biosynthetic process pyrimidine nucleobase biosynthetic process organonitrogen compound biosynthetic process primary metabolic process nucleobase-containing compound metabolic process pyrimidine nucleobase metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process nucleobase-containing small molecule metabolic process nucleobase metabolic process organic cyclic compound biosynthetic process organic substance biosynthetic process organonitrogen compound metabolic process pyrimidine-containing compound metabolic process nucleobase biosynthetic process pyrimidine nucleobase biosynthetic process organonitrogen compound biosynthetic process primary metabolic process nucleobase-containing compound metabolic process pyrimidine nucleobase metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process nucleobase-containing small molecule metabolic process nucleobase metabolic process organic cyclic compound biosynthetic process organic substance biosynthetic process 'de novo' pyrimidine nucleobase biosynthetic process small molecule metabolic process metabolic process pyrimidine-containing compound biosynthetic process nucleotide biosynthetic process pyrimidine nucleotide metabolic process phosphate-containing compound metabolic process phosphorus metabolic process nucleoside phosphate metabolic process cellular metabolic process nucleobase-containing compound biosynthetic process nucleotide metabolic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process cellular process pyrimidine nucleotide biosynthetic process	protein-containing complex catalytic complex aspartate carbamoyltransferase complex transferase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR006132	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding	Domain
A, B, C	IPR006131	Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain	Domain
A, B, C	IPR036901	Aspartate/ornithine carbamoyltransferase superfamily	Homologous Superfamily
A, B, C	IPR006130	Aspartate/ornithine carbamoyltransferase	Family
A, B, C	IPR002082	Aspartate carbamoyltransferase	Family
D, E, F	IPR036792	Aspartate carbamoyltransferase regulatory subunit, C-terminal domain superfamily	Homologous Superfamily
D, E, F	IPR036793	Aspartate carbamoyltransferase regulatory subunit, N-terminal domain superfamily	Homologous Superfamily
D, E, F	IPR020542	Aspartate carbamoyltransferase regulatory subunit, C-terminal	Domain
D, E, F	IPR020545	Aspartate carbamoyltransferase regulatory subunit, N-terminal	Domain
D, E, F	IPR002801	Aspartate transcarbamylase regulatory subunit	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.