2AYI

Wild-type AmpT from Thermus thermophilus

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ayia1	Multi-domain proteins (alpha and beta)	Thermophilic metalloprotease-like	Thermophilic metalloprotease-like	Thermophilic metalloprotease (M29)	Aminopeptidase T	(Thermus thermophilus ) [TaxId: 274 ],	SCOPe (2.08)
B	d2ayib1	Multi-domain proteins (alpha and beta)	Thermophilic metalloprotease-like	Thermophilic metalloprotease-like	Thermophilic metalloprotease (M29)	Aminopeptidase T	(Thermus thermophilus ) [TaxId: 274 ],	SCOPe (2.08)
C	d2ayic1	Multi-domain proteins (alpha and beta)	Thermophilic metalloprotease-like	Thermophilic metalloprotease-like	Thermophilic metalloprotease (M29)	Aminopeptidase T	(Thermus thermophilus ) [TaxId: 274 ],	SCOPe (2.08)
D	d2ayid1	Multi-domain proteins (alpha and beta)	Thermophilic metalloprotease-like	Thermophilic metalloprotease-like	Thermophilic metalloprotease (M29)	Aminopeptidase T	(Thermus thermophilus ) [TaxId: 274 ],	SCOPe (2.08)
E	d2ayie1	Multi-domain proteins (alpha and beta)	Thermophilic metalloprotease-like	Thermophilic metalloprotease-like	Thermophilic metalloprotease (M29)	Aminopeptidase T	(Thermus thermophilus ) [TaxId: 274 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Thermophilic metalloprotease (M29)	8025105	4000446	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thermophilic metalloprotease C-terminal domain-like	8037484	3000317	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thermophilic metalloprotease N-terminal domain-like	8054264	3002286	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Thermophilic metalloprotease N-terminal domain-like	8054264	3002286	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Thermophilic metalloprotease C-terminal domain-like	8037484	3000317	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Thermophilic metalloprotease N-terminal domain-like	8054264	3002286	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Thermophilic metalloprotease C-terminal domain-like	8037484	3000317	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Thermophilic metalloprotease C-terminal domain-like	8037484	3000317	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Thermophilic metalloprotease N-terminal domain-like	8054264	3002286	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Thermophilic metalloprotease C-terminal domain-like	8037484	3000317	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Thermophilic metalloprotease N-terminal domain-like	8054264	3002286	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02073	e2ayiA1	A: beta complex topology	X: Barrel domain in thermophilic metalloproteases (M29) (From Topology)	H: Barrel domain in thermophilic metalloproteases (M29) (From Topology)	T: Barrel domain in thermophilic metalloproteases (M29)	F: PF02073	ECOD (1.6)
A	PF02073	e2ayiA2	A: a/b three-layered sandwiches	X: Middle domain in Argonaute homologs (From Topology)	H: Middle domain in Argonaute homologs (From Topology)	T: Middle domain in Argonaute homologs	F: PF02073	ECOD (1.6)
B	PF02073	e2ayiB2	A: a/b three-layered sandwiches	X: Middle domain in Argonaute homologs (From Topology)	H: Middle domain in Argonaute homologs (From Topology)	T: Middle domain in Argonaute homologs	F: PF02073	ECOD (1.6)
C	PF02073	e2ayiC2	A: a/b three-layered sandwiches	X: Middle domain in Argonaute homologs (From Topology)	H: Middle domain in Argonaute homologs (From Topology)	T: Middle domain in Argonaute homologs	F: PF02073	ECOD (1.6)
D	PF02073	e2ayiD2	A: a/b three-layered sandwiches	X: Middle domain in Argonaute homologs (From Topology)	H: Middle domain in Argonaute homologs (From Topology)	T: Middle domain in Argonaute homologs	F: PF02073	ECOD (1.6)
E	PF02073	e2ayiE2	A: a/b three-layered sandwiches	X: Middle domain in Argonaute homologs (From Topology)	H: Middle domain in Argonaute homologs (From Topology)	T: Middle domain in Argonaute homologs	F: PF02073	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.1830.10	Alpha Beta	3-Layer(aba) Sandwich	Thermophilic metalloprotease-like	Thermophilic metalloprotease (M29)	CATH (4.3.0)
B	3.40.1830.10	Alpha Beta	3-Layer(aba) Sandwich	Thermophilic metalloprotease-like	Thermophilic metalloprotease (M29)	CATH (4.3.0)
C	3.40.1830.10	Alpha Beta	3-Layer(aba) Sandwich	Thermophilic metalloprotease-like	Thermophilic metalloprotease (M29)	CATH (4.3.0)
D	3.40.1830.10	Alpha Beta	3-Layer(aba) Sandwich	Thermophilic metalloprotease-like	Thermophilic metalloprotease (M29)	CATH (4.3.0)
E	3.40.1830.10	Alpha Beta	3-Layer(aba) Sandwich	Thermophilic metalloprotease-like	Thermophilic metalloprotease (M29)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF02073	Thermophilic metalloprotease (M29) (Peptidase_M29)	Thermophilic metalloprotease (M29)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Aminopeptidase T	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding aminopeptidase activity exopeptidase activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR035097	Peptidase M29, N-terminal	Homologous Superfamily
A, B, C, D, E	IPR000787	Peptidase M29	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.