2AVU

Structure of the Escherichia coli FlhDC complex, a prokaryotic heteromeric regulator of transcription

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2avua_	All alpha proteins	Flagellar transcriptional activator FlhD	Flagellar transcriptional activator FlhD	Flagellar transcriptional activator FlhD	Flagellar transcriptional activator FlhD	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d2avub_	All alpha proteins	Flagellar transcriptional activator FlhD	Flagellar transcriptional activator FlhD	Flagellar transcriptional activator FlhD	Flagellar transcriptional activator FlhD	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d2avuc_	All alpha proteins	Flagellar transcriptional activator FlhD	Flagellar transcriptional activator FlhD	Flagellar transcriptional activator FlhD	Flagellar transcriptional activator FlhD	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d2avud_	All alpha proteins	Flagellar transcriptional activator FlhD	Flagellar transcriptional activator FlhD	Flagellar transcriptional activator FlhD	Flagellar transcriptional activator FlhD	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E	d2avue1	Multi-domain proteins (alpha and beta)	FlhC-like	FlhC-like	FlhC-like	Flagellar transcriptional activator FlhC	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F	d2avuf_	Multi-domain proteins (alpha and beta)	FlhC-like	FlhC-like	FlhC-like	Flagellar transcriptional activator FlhC	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Flagellar transcriptional activator FlhD	8032668	3000232	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Flagellar transcriptional activator FlhD	8032668	3000232	SCOP2B (2022-06-29)
E	SCOP2 Family	FlhC-like	8020290	4002657	SCOP2 (2022-06-29)
E	SCOP2 Superfamily	FlhC-like	8032670	3001562	SCOP2 (2022-06-29)
F	SCOP2B Superfamily	FlhC-like	8032670	3001562	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05247	e2avuA1	A: alpha arrays	X: HTH	H: HTH	T: Flagellar transcriptional activator FlhD	F: PF05247	ECOD (1.6)
B	PF05247	e2avuB1	A: alpha arrays	X: HTH	H: HTH	T: Flagellar transcriptional activator FlhD	F: PF05247	ECOD (1.6)
C	PF05247	e2avuC1	A: alpha arrays	X: HTH	H: HTH	T: Flagellar transcriptional activator FlhD	F: PF05247	ECOD (1.6)
D	PF05247	e2avuD1	A: alpha arrays	X: HTH	H: HTH	T: Flagellar transcriptional activator FlhD	F: PF05247	ECOD (1.6)
E	PF05280	e2avuE2	A: alpha arrays	X: HTH	H: helical bundles in FlhC-like proteins (From Topology)	T: helical bundles in FlhC-like proteins	F: PF05280	ECOD (1.6)
E	PF05280	e2avuE3	A: few secondary structure elements	X: Rubredoxin-like	H: FlhC-like (From Topology)	T: FlhC-like	F: PF05280	ECOD (1.6)
F	PF05280	e2avuF2	A: alpha arrays	X: HTH	H: helical bundles in FlhC-like proteins (From Topology)	T: helical bundles in FlhC-like proteins	F: PF05280	ECOD (1.6)
F	PF05280	e2avuF3	A: few secondary structure elements	X: Rubredoxin-like	H: FlhC-like (From Topology)	T: FlhC-like	F: PF05280	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.4000.10	Mainly Alpha	Orthogonal Bundle	Flagellar transcriptional activator fold	Flagellar transcriptional activator FlhD	CATH (4.3.0)
B	1.10.4000.10	Mainly Alpha	Orthogonal Bundle	Flagellar transcriptional activator fold	Flagellar transcriptional activator FlhD	CATH (4.3.0)
C	1.10.4000.10	Mainly Alpha	Orthogonal Bundle	Flagellar transcriptional activator fold	Flagellar transcriptional activator FlhD	CATH (4.3.0)
D	1.10.4000.10	Mainly Alpha	Orthogonal Bundle	Flagellar transcriptional activator fold	Flagellar transcriptional activator FlhD	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF05247	Flagellar transcriptional activator (FlhD) (FlhD)	Flagellar transcriptional activator (FlhD)	-	Family
E, F	PF05280	Flagellar transcriptional activator (FlhC) (FlhC)	Flagellar transcriptional activator (FlhC)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Transcriptional activator flhD	DNA binding binding organic cyclic compound binding nucleic acid binding	organelle assembly cell projection organization non-membrane-bounded organelle assembly bacterial-type flagellum assembly cellular component biogenesis cellular component organization bacterial-type flagellum organization organelle organization cellular component assembly cellular process cellular component organization or biogenesis cell projection assembly positive regulation of organelle organization regulation of cellular process organelle assembly cell projection organization non-membrane-bounded organelle assembly bacterial-type flagellum assembly cellular component biogenesis cellular component organization bacterial-type flagellum organization organelle organization cellular component assembly cellular process cellular component organization or biogenesis cell projection assembly positive regulation of organelle organization regulation of cellular process positive regulation of cellular component organization regulation of cellular component organization positive regulation of biological process positive regulation of cell projection organization positive regulation of cellular process regulation of bacterial-type flagellum assembly regulation of biological process positive regulation of cellular component biogenesis regulation of cell projection assembly regulation of cell projection organization positive regulation of bacterial-type flagellum assembly biological regulation regulation of cellular component biogenesis regulation of organelle organization regulation of organelle assembly positive regulation of organelle assembly cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	protein-containing complex transcription regulator complex intracellular anatomical structure cytoplasm cellular anatomical entity
E, F	Flagellar transcriptional activator flhC	DNA binding binding organic cyclic compound binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular component organization bacterial-type flagellum organization organelle organization cell projection organization cellular process cellular component organization or biogenesis positive regulation of organelle organization regulation of cellular process positive regulation of cellular component organization regulation of cellular component organization non-membrane-bounded organelle assembly bacterial-type flagellum assembly positive regulation of biological process cellular component biogenesis cellular component organization bacterial-type flagellum organization organelle organization cell projection organization cellular process cellular component organization or biogenesis positive regulation of organelle organization regulation of cellular process positive regulation of cellular component organization regulation of cellular component organization non-membrane-bounded organelle assembly bacterial-type flagellum assembly positive regulation of biological process cellular component biogenesis cellular component assembly positive regulation of cell projection organization positive regulation of cellular process regulation of bacterial-type flagellum assembly regulation of biological process organelle assembly positive regulation of cellular component biogenesis regulation of cell projection assembly regulation of cell projection organization positive regulation of bacterial-type flagellum assembly biological regulation regulation of cellular component biogenesis regulation of organelle organization regulation of organelle assembly cell projection assembly positive regulation of organelle assembly cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	protein-containing complex transcription regulator complex intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR023559	Flagellar transcriptional activator FlhD	Family
A, B, C, D	IPR036194	Flagellar transcriptional activator FlhD superfamily	Homologous Superfamily
E, F	IPR007944	Flagellar transcriptional activator FlhC	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.