2AUC

Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	EF-hand_7_8	e2aucB2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
B	EUF07935	e2aucB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EUF07935	ECOD (1.6)
C	EF-hand_7_8	e2aucC1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
C	EUF07935	e2aucC2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EUF07935	ECOD (1.6)
A	EF-hand_7_8	e2aucA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_8	ECOD (1.6)
A	EUF07935	e2aucA2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EUF07935	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
C	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF13405	EF-hand domain (EF-hand_6)	EF-hand domain	-	Domain
A, B, C	PF21550	Myosin A tail domain interacting protein, N-terminal (MTIP_N)	Myosin A tail domain interacting protein, N-terminal	This domain is found at the N-terminal end of Myosin A tail domain interacting protein from Plasmodium falciparum (MTIP) and in similar eukaryotic sequences. MTIP is one of the proteins that empower host cell invasion. This domain adopts an EF hand c ...	This domain is found at the N-terminal end of Myosin A tail domain interacting protein from Plasmodium falciparum (MTIP) and in similar eukaryotic sequences. MTIP is one of the proteins that empower host cell invasion. This domain adopts an EF hand configuration [1-5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Myosin A Tail Interacting Protein	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	-	-
D	Myosin A	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal motor activity cytoskeletal protein binding actin binding protein binding	-	cell periphery plasma membrane membrane cellular anatomical entity intracellular organelle protein-containing complex intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle myosin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR049007	Myosin A tail domain interacting protein, EF-hand domain	Domain
A, B, C	IPR002048	EF-hand domain	Domain
A, B, C	IPR011992	EF-hand domain pair	Homologous Superfamily
D	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
D	IPR036044	Class XIV myosin, motor domain	Domain
D	IPR001609	Myosin head, motor domain	Domain
D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.