2AGH

Structural basis for cooperative transcription factor binding to the CBP coactivator

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2aghb_	All alpha proteins	Kix domain of CBP (creb binding protein)	Kix domain of CBP (creb binding protein)	Kix domain of CBP (creb binding protein)	Kix domain of CBP (creb binding protein)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Kix domain-like	8041523	3001244	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF02172	e2aghB1	A: alpha arrays	X: RuvA-C	H: Elongation factor TFIIS domain 2/ Kix domain of creb binding protein (From Topology)	T: Elongation factor TFIIS domain 2/ Kix domain of creb binding protein	F: PF02172	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.246.20	Mainly Alpha	Orthogonal Bundle	Serum Albumin	Chain A, Domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07988	LMSTEN motif (LMSTEN)	LMSTEN motif	-	Motif
B	PF02172	KIX domain (KIX)	KIX domain	CBP and P300 bind to the CREB via a domain known as KIX [1]. The KIX domain of CBP also binds to transactivation domains of other nuclear factors including Myb and Jun.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Myb proto-oncogene protein	DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific WD40-repeat domain binding protein binding protein domain specific binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process regulation of transforming growth factor beta production multicellular organismal process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process transforming growth factor beta production positive regulation of cellular process positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of transforming growth factor beta production positive regulation of cytokine production positive regulation of cellular biosynthetic process cell cycle mitotic cell cycle developmental process negative regulation of hematopoietic progenitor cell differentiation regulation of developmental process cellular developmental process negative regulation of developmental process hemopoiesis cell development regulation of cell differentiation cell differentiation anatomical structure development negative regulation of cell differentiation regulation of hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation B cell activation cell activation mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation immune system process leukocyte differentiation immune system development animal organ development gland development hematopoietic or lymphoid organ development multicellular organism development thymus development system development multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells myeloid cell differentiation myeloid cell development fibroblast proliferation cell population proliferation positive regulation of cell population proliferation regulation of hepatic stellate cell proliferation regulation of fibroblast proliferation positive regulation of hepatic stellate cell proliferation regulation of cell population proliferation positive regulation of fibroblast proliferation hepatic stellate cell proliferation digestive system development tube development embryo development digestive tract development embryonic organ development embryonic digestive tract development neuron apoptotic process positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process positive regulation of neuron apoptotic process programmed cell death regulation of neuron apoptotic process regulation of miRNA metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of miRNA transcription positive regulation of miRNA metabolic process miRNA transcription positive regulation of RNA biosynthetic process ncRNA metabolic process regulation of miRNA transcription embryo development ending in birth or egg hatching chordate embryonic development in utero embryonic development regulation of megakaryocyte differentiation megakaryocyte differentiation regulation of cell development negative regulation of megakaryocyte differentiation regulation of immune system process regulation of multicellular organismal development regulation of myeloid cell differentiation negative regulation of myeloid cell differentiation regulation of hemopoiesis regulation of cell activation positive regulation of hepatic stellate cell activation fibroblast activation regulation of hepatic stellate cell activation positive regulation of cell activation hepatic stellate cell activation spleen development positive regulation of testosterone secretion positive regulation of cell communication regulation of localization regulation of hormone secretion transport signaling regulation of lipid transport organic hydroxy compound transport positive regulation of secretion by cell hormone secretion cell communication localization secretion by cell positive regulation of hormone secretion regulation of secretion by cell positive regulation of secretion signal release regulation of biological quality regulation of signaling regulation of transport secretion regulation of hormone levels organic substance transport lipid localization cell-cell signaling export from cell lipid transport positive regulation of lipid localization establishment of localization regulation of secretion testosterone secretion positive regulation of lipid transport positive regulation of transport regulation of lipid localization lipid export from cell macromolecule localization regulation of testosterone secretion hormone transport regulation of cell communication positive regulation of signaling cellular response to stimulus response to organic substance response to interleukin-6 response to stimulus cellular response to interleukin-6 response to cytokine cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance mitotic cell cycle process cell cycle phase transition G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle phase transition cell cycle process cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation type 2 immune response T cell activation involved in immune response alpha-beta T cell activation involved in immune response T cell activation CD4-positive, alpha-beta T cell activation leukocyte activation involved in immune response alpha-beta T cell activation T-helper 2 cell differentiation T cell differentiation lymphocyte activation involved in immune response immune response T-helper cell differentiation T cell differentiation involved in immune response immune effector process regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation erythrocyte differentiation myeloid cell homeostasis erythrocyte homeostasis monoatomic ion transport monoatomic cation transport calcium ion transport metal ion transport stem cell division cell division transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II positive regulation of nervous system development regulation of neurogenesis regulation of gliogenesis positive regulation of glial cell proliferation positive regulation of gliogenesis regulation of nervous system development positive regulation of developmental process neurogenesis regulation of glial cell proliferation gliogenesis positive regulation of cell differentiation positive regulation of neurogenesis positive regulation of cell development nervous system development glial cell proliferation collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process positive regulation of collagen metabolic process positive regulation of collagen biosynthetic process collagen metabolic process positive regulation of transcription by RNA polymerase II response to leukemia inhibitory factor cellular response to leukemia inhibitory factor	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle cytoplasm cytosol membrane-enclosed lumen RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B	Crebbp protein	transcription factor binding basal transcription machinery binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding TFIIB-class transcription factor binding bHLH transcription factor binding DNA-binding transcription factor binding MRF binding signaling receptor binding peroxisome proliferator activated receptor binding acetyltransferase activity transcription factor binding basal transcription machinery binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding TFIIB-class transcription factor binding bHLH transcription factor binding DNA-binding transcription factor binding MRF binding signaling receptor binding peroxisome proliferator activated receptor binding acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity DNA binding organic cyclic compound binding nucleic acid binding protein-containing complex binding molecular adaptor activity catalytic activity, acting on a protein N-acetyltransferase activity histone H3 acetyltransferase activity peptide N-acetyltransferase activity histone H3K27 acetyltransferase activity histone acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity N-acyltransferase activity p53 binding protein domain specific binding cAMP response element binding protein binding RNA polymerase II-specific DNA-binding transcription factor binding chromatin binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity damaged DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding histone H3K18 acetyltransferase activity transcription corepressor activity transcription coregulator binding transcription coactivator binding SMAD binding chromatin DNA binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding disordered domain specific binding	organic substance metabolic process organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process protein destabilization regulation of protein stability biological regulation regulation of biological quality developmental process multicellular organismal process organic substance metabolic process organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process protein destabilization regulation of protein stability biological regulation regulation of biological quality developmental process multicellular organismal process germ-line stem cell population maintenance maintenance of cell number stem cell population maintenance regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process cellular process regulation of metabolic process positive regulation of cellular biosynthetic process cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus negative regulation of viral process regulation of viral process viral process negative regulation of biological process positive regulation of DNA-binding transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of molecular function organic cyclic compound metabolic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of DNA-templated transcription regulation of developmental process cellular developmental process cell projection organization positive regulation of dendritic spine development cell development regulation of dendritic spine development neuron projection development cellular component organization positive regulation of developmental process neurogenesis multicellular organism development neuron differentiation dendrite development cell differentiation anatomical structure development cellular component organization or biogenesis system development dendritic spine development plasma membrane bounded cell projection organization nervous system development generation of neurons neuron development signaling non-canonical NF-kappaB signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction regulation of cell cycle phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle regulation of cell cycle cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of cell cycle process positive regulation of cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process protein localization regulation of localization cellular localization regulation of protein localization positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization adult behavior response to organic substance response to organonitrogen compound response to oxygen-containing compound response to nitrogen compound response to alkaloid behavior behavioral response to cocaine response to chemical response to organic cyclic compound response to cocaine anatomical structure morphogenesis head development face morphogenesis head morphogenesis face development body morphogenesis positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway positive regulation of signal transduction cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction regulation of transforming growth factor beta receptor signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway positive regulation of signaling peptidyl-lysine acetylation N-terminal peptidyl-lysine acetylation peptidyl-lysine modification protein acylation protein maturation peptidyl-amino acid modification N-terminal protein amino acid acetylation protein acetylation N-terminal protein amino acid modification negative regulation of type I interferon production cytokine production regulation of cytokine production regulation of multicellular organismal process regulation of interferon-beta production interferon-beta production type I interferon production negative regulation of cytokine production negative regulation of gene expression negative regulation of interferon-beta production negative regulation of multicellular organismal process regulation of type I interferon production system process learning or memory long-term memory nervous system process cognition memory positive regulation of cell adhesion molecule production regulation of cell adhesion molecule production cell adhesion molecule production rhythmic process response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV regulation of non-canonical NF-kappaB signal transduction regulation of intracellular signal transduction positive regulation of intracellular signal transduction positive regulation of non-canonical NF-kappaB signal transduction response to hepatocyte growth factor cellular response to hepatocyte growth factor stimulus transcription by RNA polymerase I regulation of transcription by RNA polymerase I negative regulation of transcription by RNA polymerase I cellular response to virus biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus	protein-containing complex transcription regulator complex intracellular anatomical structure cytoplasm cellular anatomical entity chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region outer kinetochore condensed chromosome, centromeric region protein-containing complex transcription regulator complex intracellular anatomical structure cytoplasm cellular anatomical entity chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region outer kinetochore condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle protein-DNA complex chromatin catalytic complex transferase complex histone acetyltransferase complex acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen nuclear body PML body
C	Zinc finger protein HRX	sequence-specific DNA binding DNA binding binding organic cyclic compound binding unmethylated CpG binding nucleic acid binding protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity histone H3K4 methyltransferase activity sequence-specific DNA binding DNA binding binding organic cyclic compound binding unmethylated CpG binding nucleic acid binding protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity histone H3K4 methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity methyltransferase activity catalytic activity histone H3K4 trimethyltransferase activity S-methyltransferase activity protein-cysteine methyltransferase activity histone H3K4 monomethyltransferase activity DNA secondary structure binding minor groove of adenine-thymine-rich DNA binding identical protein binding protein binding modification-dependent protein binding lysine-acetylated histone binding histone binding acetylation-dependent protein binding protein-containing complex binding chromatin binding protein homodimerization activity protein dimerization activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription transcription by RNA polymerase II chromatin organization organic substance biosynthetic process positive regulation of macromolecule metabolic process transcription initiation at RNA polymerase II promoter regulation of biological process cellular metabolic process regulation of cellular metabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription transcription by RNA polymerase II chromatin organization organic substance biosynthetic process positive regulation of macromolecule metabolic process transcription initiation at RNA polymerase II promoter regulation of biological process cellular metabolic process regulation of cellular metabolic process primary metabolic process regulation of gene expression organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process protein-DNA complex organization cellular component organization RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process chromatin remodeling cellular component organization or biogenesis positive regulation of cellular process regulation of biosynthetic process protein-containing complex organization epigenetic regulation of gene expression biological regulation regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of cellular biosynthetic process positive regulation of gene expression cellular process positive regulation of cellular biosynthetic process behavior multicellular organismal process exploration behavior organonitrogen compound metabolic process macromolecule modification protein metabolic process protein modification process multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells within a tissue anatomical structure homeostasis tissue homeostasis homeostasis of number of cells apoptotic process cell death programmed cell death response to stimulus response to potassium ion response to metal ion response to chemical response to inorganic substance rhythmic process circadian regulation of gene expression circadian rhythm developmental process cellular developmental process hemopoiesis animal organ development cell development embryo development multicellular organism development embryonic hemopoiesis cell differentiation anatomical structure development embryonic organ development immune system development spleen development immune system process hematopoietic or lymphoid organ development system development fibroblast proliferation cell population proliferation negative regulation of cell population proliferation negative regulation of biological process regulation of fibroblast proliferation regulation of cell population proliferation negative regulation of cellular process negative regulation of fibroblast proliferation definitive hemopoiesis regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription regulation of RNA biosynthetic process positive regulation of RNA biosynthetic process cellular component biogenesis cellular component assembly protein-containing complex assembly cellular response to endogenous stimulus cellular response to growth factor stimulus response to transforming growth factor beta cellular response to transforming growth factor beta stimulus response to endogenous stimulus response to growth factor response to light stimulus system process learning learning or memory nervous system process visual learning visual behavior cognition associative learning response to radiation response to abiotic stimulus regulation of neuronal synaptic plasticity regulation of synaptic plasticity trans-synaptic signaling regulation of short-term neuronal synaptic plasticity regulation of signaling modulation of chemical synaptic transmission signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of biological quality mononuclear cell differentiation lymphocyte activation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response leukocyte activation alpha-beta T cell differentiation type 2 immune response T cell activation involved in immune response alpha-beta T cell activation involved in immune response T cell activation CD4-positive, alpha-beta T cell activation leukocyte activation involved in immune response alpha-beta T cell activation T-helper 2 cell differentiation T cell differentiation lymphocyte activation involved in immune response immune response T-helper cell differentiation cell activation T cell differentiation involved in immune response immune effector process leukocyte differentiation membrane depolarization regulation of membrane potential post-embryonic development anterior/posterior pattern specification pattern specification process regionalization negative regulation of DNA methylation-dependent heterochromatin formation negative regulation of heterochromatin formation negative regulation of cellular metabolic process regulation of heterochromatin formation regulation of chromatin organization negative regulation of cellular component organization regulation of DNA methylation-dependent heterochromatin formation negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of cellular component organization negative regulation of chromatin organization DNA methylation-dependent heterochromatin formation negative regulation of macromolecule metabolic process heterochromatin formation negative regulation of biosynthetic process facultative heterochromatin formation	membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen intracellular organelle nucleoplasm membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle methyltransferase complex nuclear lumen cytoplasm cytosol MLL1/2 complex MLL1 complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015395	C-myb, C-terminal	Domain
A	IPR012642	Transcription regulator Wos2-domain	Domain
A	IPR017930	Myb domain	Domain
A	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
A	IPR001005	SANT/Myb domain	Domain
B	IPR043145	Zinc finger, ZZ-type superfamily	Homologous Superfamily
B	IPR018359	Bromodomain, conserved site	Conserved Site
B	IPR036529	Coactivator CBP, KIX domain superfamily	Homologous Superfamily
B	IPR009110	Nuclear receptor coactivator, interlocking	Homologous Superfamily
B	IPR000197	Zinc finger, TAZ-type	Domain
B	IPR000433	Zinc finger, ZZ-type	Domain
B	IPR003101	Coactivator CBP, KIX domain	Domain
B	IPR013178	Histone acetyltransferase Rtt109/CBP	Family
B	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
B	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
B	IPR010303	CREB-binding protein/p300, atypical RING domain	Domain
B	IPR001487	Bromodomain	Domain
B	IPR035898	TAZ domain superfamily	Homologous Superfamily
B	IPR037073	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily	Homologous Superfamily
B	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking	Domain
B	IPR038547	CBP/p300, atypical RING domain superfamily	Homologous Superfamily
B	IPR031162	CBP/p300-type histone acetyltransferase domain	Domain
C	IPR001965	Zinc finger, PHD-type	Domain
C	IPR046341	SET domain superfamily	Homologous Superfamily
C	IPR001214	SET domain	Domain
C	IPR044133	KMT2A, PHD domain 3	Domain
C	IPR003616	Post-SET domain	Domain
C	IPR034732	Extended PHD (ePHD) domain	Domain
C	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
C	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
C	IPR003888	FY-rich, N-terminal	Conserved Site
C	IPR001487	Bromodomain	Domain
C	IPR002857	Zinc finger, CXXC-type	Domain
C	IPR019787	Zinc finger, PHD-finger	Domain
C	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
C	IPR041958	KMT2A, ePHD domain	Domain
C	IPR047219	Histone-lysine N-methyltransferase 2A/2B, SET domain	Domain
C	IPR042025	KMT2A, PHD domain 2	Domain
C	IPR003889	FY-rich, C-terminal	Conserved Site
C	IPR016569	Methyltransferase, trithorax	Family
C	IPR042023	KMT2A, PHD domain 1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C	Pharos: Q03164	myeloid leukemia acute myeloid leukemia acute monocytic leukemia Wiedemann-Steiner syndrome transitional cell carcinoma urinary bladder cancer cancer Chromosome Aberrations acute biphenotypic leukemia leukemia adenocarcinoma chronic monocytic leukemia acute myelomonocytic leukemia M4 tubular adenocarcinoma prostate cancer myeloid leukemia acute myeloid leukemia acute monocytic leukemia Wiedemann-Steiner syndrome transitional cell carcinoma urinary bladder cancer cancer Chromosome Aberrations acute biphenotypic leukemia leukemia adenocarcinoma chronic monocytic leukemia acute myelomonocytic leukemia M4 tubular adenocarcinoma prostate cancer granular cell carcinoma small cell lung carcinoma lymphoid leukemia osteosarcoma Pick disease Cornelia de Lange syndrome cribriform carcinoma of breast gastric neoplasm small cell carcinoma spina bifida hereditary diffuse gastric adenocarcinoma tuberculosis urinary bladder neoplasm Alzheimer disease malignant ependymoma medulloblastoma breast cancer celiac disease ovarian cancer Cornelia de Lange syndrome 1 primitive neuroectodermal tumor psoriasis acute lymphoblastic leukemia glioblastoma hematologic disease intellectual disability subependymal giant cell astrocytoma astrocytic tumor malignant mesothelioma bilineal acute myeloid leukemia metabolic syndrome X Burkitt lymphoma oligodendroglioma childhood acute lymphoblastic leukemia pancreatic ductal adenocarcinoma congenital anemia cribriform carcinoma gastric cancer schizophrenia hepatocellular carcinoma large cell medulloblastoma acute undifferentiated leukemia X-linked mixed deafness with perilymphatic gusher atypical teratoid rhabdoid tumor brain glioma