Annotations: 2AEN

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d2aenc_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	(Human rotavirus A ) [TaxId: 10941 ],	SCOPe (2.08)
A	d2aena_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	(Human rotavirus A ) [TaxId: 10941 ],	SCOPe (2.08)
B	d2aenb_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	(Human rotavirus A ) [TaxId: 10941 ],	SCOPe (2.08)
D	d2aend_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	(Human rotavirus A ) [TaxId: 10941 ],	SCOPe (2.08)
E	d2aene_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	(Human rotavirus A ) [TaxId: 10941 ],	SCOPe (2.08)
F	d2aenf_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	(Human rotavirus A ) [TaxId: 10941 ],	SCOPe (2.08)
G	d2aeng_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	(Human rotavirus A ) [TaxId: 10941 ],	SCOPe (2.08)
H	d2aenh_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	automated matches	automated matches	(Human rotavirus A ) [TaxId: 10941 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8077038	3000120	SCOP2B (2022-06-29)
A	SCOP2 Family	vp4 sialic acid binding domain	8077037	4002124	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Concanavalin A-like lectins/glucanases	8077038	3000120	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8077038	3000120	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8077038	3000120	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8077038	3000120	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8077038	3000120	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8077038	3000120	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8077038	3000120	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	VP4_haemagglut	e2aenC1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: VP4_haemagglut	ECOD (1.6)
A	VP4_haemagglut	e2aenA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: VP4_haemagglut	ECOD (1.6)
B	VP4_haemagglut	e2aenB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: VP4_haemagglut	ECOD (1.6)
D	VP4_haemagglut	e2aenD1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: VP4_haemagglut	ECOD (1.6)
E	VP4_haemagglut	e2aenE1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: VP4_haemagglut	ECOD (1.6)
F	VP4_haemagglut	e2aenF1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: VP4_haemagglut	ECOD (1.6)
G	VP4_haemagglut	e2aenG1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: VP4_haemagglut	ECOD (1.6)
H	VP4_haemagglut	e2aenH1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: VP4_haemagglut	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
B	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
D	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
E	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
F	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
G	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
H	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00426	Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain (VP4_haemagglut)	Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain	This entry represents the N-terminal concanavalin-like domain from the VP4 protein of rotavirus.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Outer capsid protein VP4, VP8* core	-	symbiont-mediated disruption of host anatomical structure symbiont entry into host cell via permeabilization of inner membrane biological process involved in interspecies interaction between organisms symbiont entry into host cell via permeabilization of host membrane viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host membrane symbiont-mediated disruption of host cellular anatomical entity symbiont entry into host cell viral process symbiont entry into host disruption of anatomical structure in another organism virion attachment to host cell symbiont-mediated disruption of host anatomical structure symbiont entry into host cell via permeabilization of inner membrane biological process involved in interspecies interaction between organisms symbiont entry into host cell via permeabilization of host membrane viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host membrane symbiont-mediated disruption of host cellular anatomical entity symbiont entry into host cell viral process symbiont entry into host disruption of anatomical structure in another organism virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host permeabilization of host organelle membrane involved in viral entry into host cell	host cellular component host intracellular part host cytoskeleton host cell part host intracellular region cellular anatomical entity host intracellular organelle membrane host intracellular membrane-bounded organelle host cell endoplasmic reticulum-Golgi intermediate compartment host cell cytoplasm host cell cytoplasm part host cell plasma membrane host cell membrane host cellular component host intracellular part host cytoskeleton host cell part host intracellular region cellular anatomical entity host intracellular organelle membrane host intracellular membrane-bounded organelle host cell endoplasmic reticulum-Golgi intermediate compartment host cell cytoplasm host cell cytoplasm part host cell plasma membrane host cell membrane viral capsid icosahedral viral capsid virion component viral outer capsid host cell endoplasmic reticulum host cell rough endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000416	Haemagglutinin outer capsid protein VP4, concanavalin-like domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR035330	Rotavirus VP4, membrane interaction domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR035329	Rotavirus VP4 helical domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR042546	Outer capsid protein VP4	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR038017	Rotavirus VP4, membrane interaction domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.