Annotations: 2ADZ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2adza1	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	Alpha-1-syntrophin	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF18012	e2adzA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF18012	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF18012	PH domain (PH_17)	PH domain	This entry represents the C-terminal part of the split PH domain from syntrophin proteins [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Alpha-1-syntrophin	protein binding binding PDZ domain binding protein domain specific binding transmembrane transporter binding channel regulator activity ion channel regulator activity molecular function regulator activity sodium channel regulator activity transporter regulator activity cytoskeletal protein binding actin binding calmodulin binding structural molecule activity protein binding binding PDZ domain binding protein domain specific binding transmembrane transporter binding channel regulator activity ion channel regulator activity molecular function regulator activity sodium channel regulator activity transporter regulator activity cytoskeletal protein binding actin binding calmodulin binding structural molecule activity nitric-oxide synthase binding enzyme binding ATPase binding	heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate cellular component organization cell junction organization neuromuscular junction development cellular process synapse organization cellular component organization or biogenesis cardiac muscle cell membrane repolarization membrane repolarization regulation of membrane repolarization ventricular cardiac muscle cell membrane repolarization regulation of cardiac muscle cell membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization regulation of membrane potential regulation of tube diameter regulation of tube size regulation of vasoconstriction by norepinephrine regulation of vasoconstriction vascular process in circulatory system regulation of vasoconstriction by circulating norepinephrine blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size regulation of localization regulation of cellular process transport monoatomic ion transmembrane transport sodium ion transmembrane transport regulation of monoatomic ion transmembrane transport regulation of sodium ion transport regulation of sodium ion transmembrane transport metal ion transport monoatomic cation transmembrane transport localization monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of transport regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport regulation of monoatomic cation transmembrane transport sodium ion transport regulation of protein modification process negative regulation of biological process regulation of primary metabolic process negative regulation of peptidyl-cysteine S-nitrosylation organic substance metabolic process peptidyl-amino acid modification negative regulation of protein modification process protein metabolic process protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process peptidyl-cysteine modification regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process peptidyl-cysteine S-nitrosylation regulation of peptidyl-cysteine S-nitrosylation macromolecule modification metabolic process macromolecule metabolic process protein nitrosylation regulation of metabolic process cardiac muscle cell contraction cardiac muscle cell action potential involved in contraction ventricular cardiac muscle cell action potential action potential actin filament-based movement cardiac muscle contraction muscle contraction muscle system process striated muscle contraction actin filament-based process actin-mediated cell contraction cardiac muscle cell action potential	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane sarcolemma anchoring junction intracellular anatomical structure cytoplasm cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane sarcolemma anchoring junction intracellular anatomical structure cytoplasm protein-containing complex glycoprotein complex plasma membrane protein complex membrane protein complex dystrophin-associated glycoprotein complex neuromuscular junction intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR015482	Syntrophin	Family
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR041428	Syntrophin, split Pleckstrin homology (PH) domain	Domain
A	IPR001478	PDZ domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.