Annotations: 2ADB

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth A]	d2adba1	Alpha and beta proteins (a+b)	Ferredoxin-like	RNA-binding domain, RBD, aka RNA recognition motif (RRM)	Canonical RBD	Polypyrimidine tract-binding protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	RRM_1_1	e2adbA1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: RRM_1_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	3.30.70.330	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	RRM (RNA recognition motif) domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth A]	PF11835	RRM-like domain (RRM_8)	RRM-like domain	This domain is related to the RRM domains suggesting it may have an RNA-binding function.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	5'-R(CPUPCPUPCPU)-3'	-	-	-
B [auth A]	Polypyrimidine tract-binding protein 1	pre-mRNA binding RNA binding binding organic cyclic compound binding nucleic acid binding DNA binding mRNA binding poly-pyrimidine tract binding single-stranded RNA binding	multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation regulation of mRNA splicing, via spliceosome mRNA processing negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process negative regulation of mRNA splicing, via spliceosome organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process RNA processing negative regulation of mRNA processing cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process negative regulation of mRNA metabolic process organic substance metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of mRNA processing RNA splicing regulation of macromolecule metabolic process gene expression regulation of RNA splicing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of RNA splicing RNA splicing, via transesterification reactions negative regulation of biosynthetic process mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of mRNA metabolic process alternative mRNA splicing, via spliceosome regulation of alternative mRNA splicing, via spliceosome negative regulation of muscle cell differentiation muscle cell differentiation muscle structure development regulation of muscle cell differentiation calcineurin-NFAT signaling cascade cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcineurin-mediated signaling positive regulation of calcineurin-NFAT signaling cascade regulation of calcium-mediated signaling signal transduction positive regulation of calcium-mediated signaling regulation of calcineurin-NFAT signaling cascade positive regulation of cellular process regulation of signaling positive regulation of calcineurin-mediated signaling positive regulation of intracellular signal transduction calcium-mediated signaling regulation of response to stimulus regulation of cell communication calcineurin-mediated signaling positive regulation of signaling viral gene expression viral process viral translation IRES-dependent viral translational initiation protein dephosphorylation regulation of protein modification process positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of phosphate metabolic process positive regulation of metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process protein modification process phosphorus metabolic process organonitrogen compound metabolic process positive regulation of phosphorus metabolic process positive regulation of dephosphorylation regulation of dephosphorylation regulation of protein dephosphorylation dephosphorylation regulation of protein metabolic process positive regulation of protein dephosphorylation macromolecule modification regulation of phosphorus metabolic process positive regulation of macromolecule biosynthetic process DNA-templated transcription transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth A]	IPR035000	PTBP1, RNA recognition motif 1	Domain
B [auth A]	IPR021790	PTBP1-like, RNA recognition motif 2	Domain
B [auth A]	IPR006536	HnRNP-L/PTB	Family
B [auth A]	IPR000504	RNA recognition motif domain	Domain
B [auth A]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
B [auth A]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
B [auth A]	IPR035001	PTBP1, RNA recognition motif 3	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth A]	Pharos: P26599	Mammary Neoplasms, Experimental sarcomatoid carcinoma carcinoma myopathy ovarian cancer primitive neuroectodermal tumor subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor Emery-Dreifuss muscular dystrophy large cell medulloblastoma malignant glioma oligodendroglioma pilocytic astrocytoma psoriasis undifferentiated carcinoma Mammary Neoplasms, Experimental sarcomatoid carcinoma carcinoma myopathy ovarian cancer primitive neuroectodermal tumor subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor Emery-Dreifuss muscular dystrophy large cell medulloblastoma malignant glioma oligodendroglioma pilocytic astrocytoma psoriasis undifferentiated carcinoma autoimmune disease diabetes mellitus glioblastoma lymphoplasmacytic lymphoma medulloblastoma osteosarcoma plasma cell myeloma astrocytic tumor Duchenne muscular dystrophy juvenile dermatomyositis malignant ependymoma mammary neoplasms, animal

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.