2ABZ

Crystal structure of C19A/C43A mutant of leech carboxypeptidase inhibitor in complex with bovine carboxypeptidase A

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2abza_	Alpha and beta proteins (a/b)	Phosphorylase/hydrolase-like	Zn-dependent exopeptidases	Pancreatic carboxypeptidases	Carboxypeptidase A	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d2abzb_	Alpha and beta proteins (a/b)	Phosphorylase/hydrolase-like	Zn-dependent exopeptidases	Pancreatic carboxypeptidases	Carboxypeptidase A	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d2abzc1	Small proteins	Carboxypeptidase inhibitor	Carboxypeptidase inhibitor	Carboxypeptidase inhibitor	Carboxypeptidase inhibitor	medicinal leech (Hirudo medicinalis ) [TaxId: 6421 ],	SCOPe (2.08)
D	d2abzd_	Small proteins	Carboxypeptidase inhibitor	Carboxypeptidase inhibitor	Carboxypeptidase inhibitor	automated matches	medicinal leech (Hirudo medicinalis ) [TaxId: 6421 ],	SCOPe (2.08)
E	d2abze_	Small proteins	Carboxypeptidase inhibitor	Carboxypeptidase inhibitor	Carboxypeptidase inhibitor	automated matches	medicinal leech (Hirudo medicinalis ) [TaxId: 6421 ],	SCOPe (2.08)
F	d2abzf_	Small proteins	Carboxypeptidase inhibitor	Carboxypeptidase inhibitor	Carboxypeptidase inhibitor	automated matches	medicinal leech (Hirudo medicinalis ) [TaxId: 6421 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Zn-dependent exopeptidases	8044569	3000662	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Zn-dependent exopeptidases	8044569	3000662	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Carboxypeptidase inhibitor	8038985	3001009	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Carboxypeptidase inhibitor	8038985	3001009	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Carboxypeptidase inhibitor	8038985	3001009	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00246	e2abzA1	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF00246	ECOD (1.6)
B	PF00246	e2abzB1	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF00246	ECOD (1.6)
C	F_UNCLASSIFIED	e2abzC1	A: few secondary structure elements	X: Carboxypeptidase inhibitor (From Topology)	H: Carboxypeptidase inhibitor (From Topology)	T: Carboxypeptidase inhibitor	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e2abzD2	A: few secondary structure elements	X: Carboxypeptidase inhibitor (From Topology)	H: Carboxypeptidase inhibitor (From Topology)	T: Carboxypeptidase inhibitor	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e2abzE1	A: few secondary structure elements	X: Carboxypeptidase inhibitor (From Topology)	H: Carboxypeptidase inhibitor (From Topology)	T: Carboxypeptidase inhibitor	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e2abzF1	A: few secondary structure elements	X: Carboxypeptidase inhibitor (From Topology)	H: Carboxypeptidase inhibitor (From Topology)	T: Carboxypeptidase inhibitor	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
B	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
C	3.30.1040.10	Alpha Beta	2-Layer Sandwich	Carboxypeptidase Inhibitor	Chain A	CATH (4.3.0)
D	3.30.1040.10	Alpha Beta	2-Layer Sandwich	Carboxypeptidase Inhibitor	Chain A	CATH (4.3.0)
E	3.30.1040.10	Alpha Beta	2-Layer Sandwich	Carboxypeptidase Inhibitor	Chain A	CATH (4.3.0)
F	3.30.1040.10	Alpha Beta	2-Layer Sandwich	Carboxypeptidase Inhibitor	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00246	Zinc carboxypeptidase (Peptidase_M14)	Zinc carboxypeptidase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Carboxypeptidase A1	peptidase activity catalytic activity, acting on a protein metallocarboxypeptidase activity hydrolase activity metallopeptidase activity exopeptidase activity catalytic activity metalloexopeptidase activity carboxypeptidase activity cation binding transition metal ion binding zinc ion binding ion binding binding peptidase activity catalytic activity, acting on a protein metallocarboxypeptidase activity hydrolase activity metallopeptidase activity exopeptidase activity catalytic activity metalloexopeptidase activity carboxypeptidase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process small molecule metabolic process cellular process organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process small molecule metabolic process cellular process organic acid metabolic process	extracellular region extracellular space cellular anatomical entity
C, D, E, F	Metallocarboxypeptidase inhibitor	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity metalloendopeptidase inhibitor activity endopeptidase inhibitor activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036990	Metallocarboxypeptidase-like, propeptide	Homologous Superfamily
A, B	IPR034248	Carboxypeptidase A, carboxypeptidase domain	Domain
A, B	IPR003146	Carboxypeptidase, activation peptide	Domain
A, B	IPR000834	Peptidase M14, carboxypeptidase A	Domain
C, D, E, F	IPR024063	Proteinase inhibitor I46, leech metallocarboxypeptidase inhibitor	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.