2A4J

Solution structure of the C-terminal domain (T94-Y172) of the human centrin 2 in complex with a 17 residues peptide (P1-XPC) from xeroderma pigmentosum group C protein

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EF-hand_7_4	e2a4jA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Centrin 2	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein-containing complex binding heterotrimeric G-protein binding cytoskeletal protein binding microtubule binding protein binding tubulin binding G-protein beta/gamma-subunit complex binding	cellular process cell cycle mitotic cell cycle developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation RNA transport nitrogen compound transport transport cellular process cell cycle mitotic cell cycle developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cell division protein localization establishment of protein localization cellular localization protein transport cellular macromolecule localization centriole assembly microtubule organizing center organization organelle assembly non-membrane-bounded organelle assembly microtubule cytoskeleton organization cellular component organization cellular component biogenesis centrosome duplication organelle organization cellular component assembly centrosome cycle microtubule-based process cellular component organization or biogenesis cytoskeleton organization centriole replication cell cycle process regulation of cytokinesis regulation of biological process regulation of cellular process regulation of cell cycle process biological regulation cytokinesis regulation of cell division regulation of cell cycle cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress metabolic process macromolecule metabolic process DNA repair	apical part of cell cellular anatomical entity membrane-bounded organelle ciliary transition zone non-motile cilium 9+0 non-motile cilium cilium neuron projection plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle photoreceptor connecting cilium intracellular organelle apical part of cell cellular anatomical entity membrane-bounded organelle ciliary transition zone non-motile cilium 9+0 non-motile cilium cilium neuron projection plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle photoreceptor connecting cilium intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle centriole cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex nuclear protein-containing complex endomembrane system organelle envelope nuclear envelope nuclear pore nuclear basket nuclear pore XPC complex nucleotide-excision repair complex transcription export complex 2 9+2 motile cilium motile cilium ciliary basal body
B	17-mer peptide P1-XPC from DNA-repair protein complementing XP-C cells	DNA binding DNA secondary structure binding DNA insertion or deletion binding double-stranded DNA binding binding organic cyclic compound binding heteroduplex DNA loop binding mismatched DNA binding nucleic acid binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding DNA-binding transcription factor binding transcription coactivator activity DNA binding DNA secondary structure binding DNA insertion or deletion binding double-stranded DNA binding binding organic cyclic compound binding heteroduplex DNA loop binding mismatched DNA binding nucleic acid binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding DNA-binding transcription factor binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity damaged DNA binding protein-containing complex binding DNA damage sensor activity small molecule sensor activity bubble DNA binding single-stranded DNA binding	response to stimulus response to chemical response to xenobiotic stimulus response to light stimulus response to radiation response to abiotic stimulus response to UV response to UV-B cellular response to stimulus mismatch repair primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process response to stimulus response to chemical response to xenobiotic stimulus response to light stimulus response to radiation response to abiotic stimulus response to UV response to UV-B cellular response to stimulus mismatch repair primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair response to auditory stimulus response to mechanical stimulus response to external stimulus regulation of biological process regulation of cell cycle phase transition regulation of cellular process regulation of cell cycle process biological regulation cell cycle phase transition mitotic cell cycle regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle mitotic cell cycle process cell cycle regulation of cell cycle mitotic cell cycle phase transition cell cycle process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process nucleotide-excision repair cellular response to environmental stimulus cellular response to light stimulus cellular response to radiation UV-damage excision repair cellular response to abiotic stimulus cellular response to UV DNA damage checkpoint signaling signaling negative regulation of biological process negative regulation of cell cycle intracellular signal transduction negative regulation of mitotic cell cycle cell communication mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction mitotic intra-S DNA damage checkpoint signaling DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling signal transduction in response to DNA damage pyrimidine dimer repair pyrimidine dimer repair by nucleotide-excision repair	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex nuclear protein-containing complex nucleotide-excision repair factor 2 complex nucleotide-excision repair complex cytosol cell periphery plasma membrane membrane nucleoplasm protein-DNA complex chromatin chromosome XPC complex site of DNA damage

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site	Conserved Site
A	IPR002048	EF-hand domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
B	IPR036985	Transglutaminase-like superfamily	Homologous Superfamily
B	IPR018325	Rad4/PNGase transglutaminase-like fold	Domain
B	IPR004583	DNA repair protein Rad4	Family
B	IPR018328	Rad4 beta-hairpin domain 3	Domain
B	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
B	IPR018327	Rad4 beta-hairpin domain 2	Domain
B	IPR018326	Rad4 beta-hairpin domain 1	Domain
B	IPR042488	Rad4, beta-hairpin domain 3 superfamily	Homologous Superfamily
B	IPR018026	DNA repair protein Rad4-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P41208	breast cancer malignant ependymoma sinusitis dermatomyositis nasopharyngeal carcinoma xeroderma pigmentosum large cell medulloblastoma ovarian cancer
B	Pharos: Q01831	xeroderma pigmentosum xeroderma pigmentosum group C Micronuclei, Chromosome-Defective non-small cell lung carcinoma liver cancer squamous cell carcinoma skin cancer autism intellectual disability lung adenocarcinoma ovarian cancer skin neoplasm xeroderma pigmentosum group A cutaneous melanoma lung benign neoplasm xeroderma pigmentosum xeroderma pigmentosum group C Micronuclei, Chromosome-Defective non-small cell lung carcinoma liver cancer squamous cell carcinoma skin cancer autism intellectual disability lung adenocarcinoma ovarian cancer skin neoplasm xeroderma pigmentosum group A cutaneous melanoma lung benign neoplasm melanoma skin basal cell carcinoma dilated cardiomyopathy inherited amino acid metabolic disorder liver neoplasm

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.