2A26

Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d2a26c2	All alpha proteins	Long alpha-hairpin	Calcyclin-binding protein-like	Siah interacting protein N terminal domain-like	Calcyclin-binding protein, CacyBP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2a26c3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2a26a1	All alpha proteins	Long alpha-hairpin	Calcyclin-binding protein-like	Siah interacting protein N terminal domain-like	Calcyclin-binding protein, CacyBP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2a26a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2a26b2	All alpha proteins	Long alpha-hairpin	Calcyclin-binding protein-like	Siah interacting protein N terminal domain-like	Calcyclin-binding protein, CacyBP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2a26b3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Calcyclin-binding protein-like	8036480	3000602	SCOP2B (2022-06-29)
A	SCOP2 Family	Siah interacting protein N terminal domain-like	8024101	4001056	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Calcyclin-binding protein-like	8036480	3000602	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Calcyclin-binding protein-like	8036480	3000602	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Siah-Interact_N	e2a26C1	A: alpha bundles	X: Long alpha-hairpin	H: Siah interacting protein N terminal domain-like (From Topology)	T: Siah interacting protein N terminal domain-like	F: Siah-Interact_N	ECOD (1.6)
A	Siah-Interact_N	e2a26A1	A: alpha bundles	X: Long alpha-hairpin	H: Siah interacting protein N terminal domain-like (From Topology)	T: Siah interacting protein N terminal domain-like	F: Siah-Interact_N	ECOD (1.6)
B	Siah-Interact_N	e2a26B1	A: alpha bundles	X: Long alpha-hairpin	H: Siah interacting protein N terminal domain-like (From Topology)	T: Siah interacting protein N terminal domain-like	F: Siah-Interact_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	4.10.860.10	Few Secondary Structures	Irregular	DNA Excision Repair, Uvrb	Chain A	CATH (4.3.0)
A	4.10.860.10	Few Secondary Structures	Irregular	DNA Excision Repair, Uvrb	Chain A	CATH (4.3.0)
B	4.10.860.10	Few Secondary Structures	Irregular	DNA Excision Repair, Uvrb	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF09032	Siah interacting protein, N terminal (Siah-Interact_N)	Siah interacting protein, N terminal	The N terminal domain of Siah interacting protein (SIP) adopts a helical hairpin structure with a hydrophobic core stabilised by a classic knobs-and-holes arrangement of side chains contributed by the two amphipathic helices. Little is known about th ...	The N terminal domain of Siah interacting protein (SIP) adopts a helical hairpin structure with a hydrophobic core stabilised by a classic knobs-and-holes arrangement of side chains contributed by the two amphipathic helices. Little is known about this domain's function, except that it is crucial for interactions with Siah. It has also been hypothesised that SIP can dimerise through this N terminal domain [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Calcyclin-binding protein	protein binding binding protein domain specific binding S100 protein binding identical protein binding protein homodimerization activity protein dimerization activity cytoskeletal protein binding tubulin binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular response to stimulus response to organic substance response to stimulus response to cytokine response to leukemia inhibitory factor cellular response to leukemia inhibitory factor developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular response to stimulus response to organic substance response to stimulus response to cytokine response to leukemia inhibitory factor cellular response to leukemia inhibitory factor cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular process cellular response to organic substance	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope organelle lumen organelle nuclear envelope lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope organelle lumen organelle nuclear envelope lumen nuclear envelope extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol protein-containing complex catalytic complex beta-catenin destruction complex intracellular protein-containing complex nucleoplasm nuclear lumen cullin-RING ubiquitin ligase complex ubiquitin ligase complex SCF ubiquitin ligase complex transferase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR007699	SGS domain	Domain
A, B, C	IPR037893	Calcyclin-binding Protein, CS domain	Domain
A, B, C	IPR007052	CS domain	Domain
A, B, C	IPR037201	Calcyclin-binding protein, N-terminal	Homologous Superfamily
A, B, C	IPR015120	Siah interacting protein, N-terminal	Domain
A, B, C	IPR008978	HSP20-like chaperone	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q9HB71	astrocytic tumor large cell medulloblastoma medulloblastoma pilocytic astrocytoma subependymal giant cell astrocytoma breast cancer lung cancer osteosarcoma plasma cell myeloma glioblastoma malignant ependymoma pancreatic intraductal papillary-mucinous neoplasm psoriasis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.