2A1D

Staphylocoagulase bound to bovine thrombin

External Resource: Annotation


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
C [auth D]Coagulase_Ce2a1dD2 A: alpha bundlesX: immunoglobulin/albumin-binding domain-likeH: Staphylocoagulase (From Topology)T: StaphylocoagulaseF: Coagulase_CECOD (1.6)
C [auth D]Coagulase_Ne2a1dD1 A: alpha bundlesX: immunoglobulin/albumin-binding domain-likeH: Staphylocoagulase (From Topology)T: StaphylocoagulaseF: Coagulase_NECOD (1.6)
F [auth H]Coagulase_Ce2a1dH2 A: alpha bundlesX: immunoglobulin/albumin-binding domain-likeH: Staphylocoagulase (From Topology)T: StaphylocoagulaseF: Coagulase_CECOD (1.6)
F [auth H]Coagulase_Ne2a1dH1 A: alpha bundlesX: immunoglobulin/albumin-binding domain-likeH: Staphylocoagulase (From Topology)T: StaphylocoagulaseF: Coagulase_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin Chain LCATH (4.3.0)
D [auth E]4.10.140.10 Few Secondary Structures Irregular Epsilon-Thrombin Chain LCATH (4.3.0)
B2.40.10.10 Mainly Beta Beta Barrel Thrombin, subunit H Trypsin-like serine proteasesCATH (4.3.0)
E [auth F]2.40.10.10 Mainly Beta Beta Barrel Thrombin, subunit H Trypsin-like serine proteasesCATH (4.3.0)
C [auth D]1.20.120.750 Mainly Alpha Up-down Bundle Four Helix Bundle (Hemerythrin (Met), subunit A) Staphylcoagulase, helix bundle domain 1CATH (4.3.0)
C [auth D]1.20.120.760 Mainly Alpha Up-down Bundle Four Helix Bundle (Hemerythrin (Met), subunit A) Staphylcoagulase, helix bundle, domain 2CATH (4.3.0)
F [auth H]1.20.120.750 Mainly Alpha Up-down Bundle Four Helix Bundle (Hemerythrin (Met), subunit A) Staphylcoagulase, helix bundle domain 1CATH (4.3.0)
F [auth H]1.20.120.760 Mainly Alpha Up-down Bundle Four Helix Bundle (Hemerythrin (Met), subunit A) Staphylcoagulase, helix bundle, domain 2CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
D [auth E]		PF09396Thrombin light chain (Thrombin_light)Thrombin light chainThrombin is an enzyme that cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII. Prothrombin is activated on the surface of a phospholipid membrane where factor Xa removes the activation peptide and cleave ...Thrombin is an enzyme that cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII. Prothrombin is activated on the surface of a phospholipid membrane where factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. This domain corresponds to the light chain of thrombin.
Domain
B,
E [auth F]		PF00089Trypsin (Trypsin)Trypsin- Domain
C [auth D],
F [auth H]		PF08764Staphylococcus aureus coagulase (Coagulase)Staphylococcus aureus coagulaseStaphylococcus aureus secretes a cofactor called coagulase. Coagulase is an extracellular protein that forms a complex with human prothrombin, and activates it without the usual proteolytic cleavages. The resulting complex directly initiates blood c ...Staphylococcus aureus secretes a cofactor called coagulase. Coagulase is an extracellular protein that forms a complex with human prothrombin, and activates it without the usual proteolytic cleavages. The resulting complex directly initiates blood clotting.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
D [auth E]		thrombin
B,
E [auth F]		thrombin
C [auth D],
F [auth H]		Staphylocoagulase - -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A,
D [auth E]		IPR018992Thrombin light chainDomain
A,
D [auth E]		IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
A,
D [auth E]		IPR037111Thrombin light chain domain superfamilyHomologous Superfamily
A,
D [auth E]		IPR003966Prothrombin/thrombinFamily
A,
D [auth E]		IPR018056Kringle, conserved siteConserved Site
A,
D [auth E]		IPR018114Serine proteases, trypsin family, histidine active siteActive Site
A,
D [auth E]		IPR013806Kringle-like foldHomologous Superfamily
A,
D [auth E]		IPR038178Kringle superfamilyHomologous Superfamily
A,
D [auth E]		IPR009003Peptidase S1, PA clanHomologous Superfamily
A,
D [auth E]		IPR001314Peptidase S1A, chymotrypsin familyFamily
A,
D [auth E]		IPR033116Serine proteases, trypsin family, serine active siteActive Site
A,
D [auth E]		IPR001254Serine proteases, trypsin domainDomain
A,
D [auth E]		IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
A,
D [auth E]		IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
A,
D [auth E]		IPR000001KringleDomain
B,
E [auth F]		IPR018992Thrombin light chainDomain
B,
E [auth F]		IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
B,
E [auth F]		IPR037111Thrombin light chain domain superfamilyHomologous Superfamily
B,
E [auth F]		IPR003966Prothrombin/thrombinFamily
B,
E [auth F]		IPR018056Kringle, conserved siteConserved Site
B,
E [auth F]		IPR018114Serine proteases, trypsin family, histidine active siteActive Site
B,
E [auth F]		IPR013806Kringle-like foldHomologous Superfamily
B,
E [auth F]		IPR038178Kringle superfamilyHomologous Superfamily
B,
E [auth F]		IPR009003Peptidase S1, PA clanHomologous Superfamily
B,
E [auth F]		IPR001314Peptidase S1A, chymotrypsin familyFamily
B,
E [auth F]		IPR033116Serine proteases, trypsin family, serine active siteActive Site
B,
E [auth F]		IPR001254Serine proteases, trypsin domainDomain
B,
E [auth F]		IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
B,
E [auth F]		IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
B,
E [auth F]		IPR000001KringleDomain
C [auth D],
F [auth H]		IPR014874Staphylocoagulase, N-terminal, subdomain 1Domain
C [auth D],
F [auth H]		IPR043071Staphylcoagulase, N-terminal, subdomain 2Homologous Superfamily
C [auth D],
F [auth H]		IPR001443Staphylocoagulase repeatRepeat
C [auth D],
F [auth H]		IPR043072Staphylcoagulase, N-terminal, subdomain 1Homologous Superfamily