2A07

Crystal Structure of Foxp2 bound Specifically to DNA.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth F]	d2a07f1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	Forkhead DNA-binding domain	Forkhead box protein P2, FOXP2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth G]	d2a07g_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth H]	d2a07h_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H [auth I]	d2a07i_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I [auth J]	d2a07j_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J [auth K]	d2a07k_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth F]	SCOP2 Family	Forkhead DNA-binding domain	8002956	4000182	SCOP2 (2022-06-29)
E [auth F]	SCOP2 Superfamily	Winged helix DNA-binding domain	8057665	3000034	SCOP2 (2022-06-29)
F [auth G]	SCOP2B Superfamily	Winged helix DNA-binding domain	8057665	3000034	SCOP2B (2022-06-29)
G [auth H]	SCOP2B Superfamily	Winged helix DNA-binding domain	8057665	3000034	SCOP2B (2022-06-29)
H [auth I]	SCOP2B Superfamily	Winged helix DNA-binding domain	8057665	3000034	SCOP2B (2022-06-29)
I [auth J]	SCOP2B Superfamily	Winged helix DNA-binding domain	8057665	3000034	SCOP2B (2022-06-29)
J [auth K]	SCOP2B Superfamily	Winged helix DNA-binding domain	8057665	3000034	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth F]	Forkhead	e2a07F1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Forkhead	ECOD (1.6)
F [auth G]	Forkhead	e2a07G1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Forkhead	ECOD (1.6)
G [auth H]	Forkhead	e2a07H1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Forkhead	ECOD (1.6)
H [auth I]	Forkhead	e2a07I1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Forkhead	ECOD (1.6)
I [auth J]	Forkhead	e2a07J2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Forkhead	ECOD (1.6)
J [auth K]	Forkhead	e2a07K2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: Forkhead	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth F]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
F [auth G]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
G [auth H]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
H [auth I]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
I [auth J]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
J [auth K]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], J [auth K]	PF00250	Forkhead domain (Forkhead)	Forkhead domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	5'-D(APAPCPTPAPTPGPAPAPAPCPAPAPAPTPTPTPTPCPCP*T)-3'	-	-	-
B, D	5'-D(TPTPAPGPGPAPAPAPAPTPTPTPGPTPTPTPCPAPTPAP*G)-3'	-	-	-
E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], J [auth K]	Forkhead box protein P2	DNA binding binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity identical protein binding protein binding protein homodimerization activity protein dimerization activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity identical protein binding protein binding protein homodimerization activity protein dimerization activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding cation binding ion binding metal ion binding small molecule binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process developmental process multicellular organismal process head development forebrain development animal organ development brain development nervous system development pallium development cerebral cortex development multicellular organism development central nervous system development anatomical structure development telencephalon development system development caudate nucleus development neural nucleus development striatum development subpallium development transcription by RNA polymerase II regulation of transcription by RNA polymerase II putamen development	intracellular organelle protein-containing complex intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], J [auth K]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], J [auth K]	IPR001766	Fork head domain	Domain
E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], J [auth K]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], J [auth K]	IPR030456	Fork head domain conserved site 2	Conserved Site
E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], J [auth K]	IPR047412	Forkhead box protein P1/P2, forkhead domain	Domain
E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], J [auth K]	IPR032354	FOXP, coiled-coil domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J], J [auth K]	Pharos: O15409	Silver-Russell syndrome childhood apraxia of speech adenoid cystic carcinoma Craniofacial Abnormalities agnosia salivary gland adenoid cystic carcinoma speech disorder ulcerative colitis gastroesophageal reflux disease intellectual disability large cell medulloblastoma malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma astrocytic tumor Silver-Russell syndrome childhood apraxia of speech adenoid cystic carcinoma Craniofacial Abnormalities agnosia salivary gland adenoid cystic carcinoma speech disorder ulcerative colitis gastroesophageal reflux disease intellectual disability large cell medulloblastoma malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma astrocytic tumor periodontitis auditory perceptual disorders schizophrenia breast carcinoma sinusitis ductal breast carcinoma in situ glioblastoma interstitial cystitis lung carcinoma malignant glioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm attention deficit hyperactivity disorder, inattentive type pilocytic astrocytoma autism breast fibroadenoma cystic fibrosis transitional cell carcinoma dyslexia invasive ductal breast carcinoma apraxia language disorder major depressive disorder medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atypical teratoid rhabdoid tumor

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.