1ZXN

Human DNA topoisomerase IIa ATPase/ADP

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1zxna2	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1zxna1	Alpha and beta proteins (a+b)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1zxnb2	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1zxnb1	Alpha and beta proteins (a+b)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1zxnc2	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1zxnc1	Alpha and beta proteins (a+b)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1zxnd2	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1zxnd1	Alpha and beta proteins (a+b)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00204	e1zxnA4	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: PF00204	ECOD (1.6)
A	PF02518	e1zxnA3	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: PF02518	ECOD (1.6)
B	PF00204	e1zxnB4	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: PF00204	ECOD (1.6)
B	PF02518	e1zxnB3	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: PF02518	ECOD (1.6)
C	PF00204	e1zxnC1	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: PF00204	ECOD (1.6)
C	PF02518	e1zxnC2	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: PF02518	ECOD (1.6)
D	PF00204	e1zxnD4	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: PF00204	ECOD (1.6)
D	PF02518	e1zxnD3	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: PF02518	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.565.10	Alpha Beta	2-Layer Sandwich	Heat Shock Protein 90	Histidine kinase-like ATPase, C-terminal domain	CATH (4.3.0)
A	3.30.230.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
B	3.30.565.10	Alpha Beta	2-Layer Sandwich	Heat Shock Protein 90	Histidine kinase-like ATPase, C-terminal domain	CATH (4.3.0)
B	3.30.230.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
C	3.30.565.10	Alpha Beta	2-Layer Sandwich	Heat Shock Protein 90	Histidine kinase-like ATPase, C-terminal domain	CATH (4.3.0)
C	3.30.230.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
D	3.30.565.10	Alpha Beta	2-Layer Sandwich	Heat Shock Protein 90	Histidine kinase-like ATPase, C-terminal domain	CATH (4.3.0)
D	3.30.230.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00204	DNA gyrase B (DNA_gyraseB)	DNA gyrase B	This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.	Domain
A, B, C, D	PF02518	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	DNA topoisomerase II, alpha isozyme	ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding protein-containing complex binding chromatin binding protein heterodimerization activity protein binding protein dimerization activity ubiquitin binding ubiquitin-like protein binding RNA binding cation binding magnesium ion binding metal ion binding identical protein binding protein homodimerization activity kinase binding protein kinase C binding enzyme binding protein kinase binding DNA binding, bending isomerase activity DNA topoisomerase activity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process multicellular organism development multicellular organismal process embryonic cleavage anatomical structure development cell division embryo development regulation of cellular process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process multicellular organism development multicellular organismal process embryonic cleavage anatomical structure development cell division embryo development regulation of cellular process viral life cycle positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of viral genome replication cellular metabolic process primary metabolic process regulation of cellular metabolic process single stranded viral RNA replication via double stranded DNA intermediate positive regulation of RNA metabolic process organic cyclic compound metabolic process biosynthetic process viral genome replication organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process regulation of single stranded viral RNA replication via double stranded DNA intermediate cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of single stranded viral RNA replication via double stranded DNA intermediate positive regulation of biosynthetic process viral RNA genome replication viral process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of viral process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of viral process regulation of viral life cycle positive regulation of RNA biosynthetic process regulation of viral genome replication positive regulation of cellular biosynthetic process cell cycle chromosome segregation cell cycle process positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death chromosome organization DNA conformation change DNA metabolic process cellular component organization DNA topological change organelle organization cellular component organization or biogenesis DNA-templated transcription transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of gene expression regulation of DNA-templated transcription positive regulation of DNA-templated transcription gene expression rhythmic process circadian rhythm regulation of circadian rhythm sexual reproduction homologous recombination reproductive process resolution of meiotic recombination intermediates meiotic cell cycle process meiosis I meiotic nuclear division reciprocal homologous recombination meiotic cell cycle DNA recombination organelle fission reciprocal meiotic recombination nuclear division meiosis I cell cycle process multicellular organismal reproductive process female gamete generation gamete generation female meiotic nuclear division DNA duplex unwinding regulation of cellular component organization negative regulation of cellular component organization negative regulation of biological process DNA geometric change regulation of chromosome organization regulation of DNA duplex unwinding regulation of organelle organization negative regulation of chromosome organization negative regulation of organelle organization negative regulation of DNA duplex unwinding negative regulation of cellular process cellular component disassembly execution phase of apoptosis apoptotic chromosome condensation chromosome condensation cellular component disassembly involved in execution phase of apoptosis apoptotic nuclear changes nuclear chromosome segregation sister chromatid segregation cellular developmental process hemopoiesis cell differentiation cell development hematopoietic progenitor cell differentiation DNA ligation	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle male germ cell nucleus nucleus germ cell nucleus intracellular membrane-bounded organelle DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex protein-containing complex catalytic complex membrane-enclosed lumen intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle male germ cell nucleus nucleus germ cell nucleus intracellular membrane-bounded organelle DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex protein-containing complex catalytic complex membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle chromosome condensed chromosome chromosome, centromeric region chromosomal region nucleoplasm ribonucleoprotein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003594	Histidine kinase/HSP90-like ATPase	Domain
A, B, C, D	IPR013506	DNA topoisomerase, type IIA, subunit B, domain 2	Domain
A, B, C, D	IPR006171	TOPRIM domain	Domain
A, B, C, D	IPR034157	DNA topoisomerase 2, TOPRIM domain	Domain
A, B, C, D	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
A, B, C, D	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily
A, B, C, D	IPR031660	C-terminal associated domain of TOPRIM	Domain
A, B, C, D	IPR002205	DNA topoisomerase, type IIA, domain A	Domain
A, B, C, D	IPR001154	DNA topoisomerase II, eukaryotic-type	Family
A, B, C, D	IPR018522	DNA topoisomerase, type IIA, conserved site	Conserved Site
A, B, C, D	IPR013760	DNA topoisomerase, type IIA-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR013758	DNA topoisomerase, type IIA, domain A, alpha-beta	Homologous Superfamily
A, B, C, D	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A, B, C, D	IPR001241	DNA topoisomerase, type IIA	Family
A, B, C, D	IPR012542	DTHCT	Domain
A, B, C, D	IPR013757	DNA topoisomerase, type IIA, alpha-helical domain superfamily	Homologous Superfamily
A, B, C, D	IPR013759	DNA topoisomerase, type IIA, subunit B, C-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P11388	adrenal cortex carcinoma malignant glioma breast carcinoma polycystic ovary syndrome neuroblastoma ovarian cancer leukemia prostate cancer lung adenocarcinoma breast cancer mixed glioma adenoid cystic carcinoma salivary gland adenoid cystic carcinoma Mammary Neoplasms, Human small cell lung carcinoma adrenal cortex carcinoma malignant glioma breast carcinoma polycystic ovary syndrome neuroblastoma ovarian cancer leukemia prostate cancer lung adenocarcinoma breast cancer mixed glioma adenoid cystic carcinoma salivary gland adenoid cystic carcinoma Mammary Neoplasms, Human small cell lung carcinoma thyroid cancer ductal breast carcinoma in situ nasopharyngeal carcinoma urinary bladder cancer esophageal adenocarcinoma glioma acute lymphoblastic leukemia Hodgkins lymphoma pancreatic intraductal papillary-mucinous neoplasm acute promyelocytic leukemia plasma cell myeloma adrenal carcinoma atopic eczema malignant colon neoplasm bone osteosarcoma salivary gland cancer Burkitt lymphoma sinusitis cystic fibrosis medulloblastoma endometriosis non-small cell lung carcinoma hepatocellular carcinoma pancreatic ductal adenocarcinoma acute monocytic leukemia IgA glomerulonephritis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia invasive ductal breast carcinoma kidney Wilms tumor atypical teratoid rhabdoid tumor malignant ependymoma relapsing-remitting multiple sclerosis cancer Sjogren syndrome testicular cancer ulcerative colitis glioblastoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma acute myeloid leukemia interstitial cystitis pilocytic astrocytoma Kaposi's sarcoma large cell medulloblastoma primitive neuroectodermal tumor astrocytic tumor lung cancer psoriasis malignant pancreatic neoplasm

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.