1ZVF

The crystal structure of 3-hydroxyanthranilate 3,4-dioxygenase from Saccharomyces cerevisiae

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1zvfa1	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	3-hydroxyanthranilic acid dioxygenase-like	3-hydroxyanthranilate-3,4-dioxygenase	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
A	d1zvfa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d1zvfb2	All beta proteins	Double-stranded beta-helix	RmlC-like cupins	automated matches	automated matches	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d1zvfb3	Artifacts	Tags	Tags	Tags	N-terminal Tags	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	3-hydroxyanthranilic acid dioxygenase-like	8021068	4002125	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RmlC-like cupins	8033448	3001825	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	RmlC-like cupins	8033448	3001825	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF06052	e1zvfA1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: PF06052	ECOD (1.6)
B	PF06052	e1zvfB1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: PF06052	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
B	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF06052	3-hydroxyanthranilic acid dioxygenase (3-HAO)	3-hydroxyanthranilic acid dioxygenase	In eukaryotes 3-hydroxyanthranilic acid dioxygenase (EC:1.13.11.6) is part of the kynurenine pathway for the degradation of tryptophan and the biosynthesis of nicotinic acid [1].The prokaryotic homolog is involved in the 2-nitrobenzoate degradation p ...	In eukaryotes 3-hydroxyanthranilic acid dioxygenase (EC:1.13.11.6) is part of the kynurenine pathway for the degradation of tryptophan and the biosynthesis of nicotinic acid [1].The prokaryotic homolog is involved in the 2-nitrobenzoate degradation pathway [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	3-hydroxyanthranilate 3,4-dioxygenase	cation binding transition metal ion binding iron ion binding ion binding binding ferrous iron binding metal ion binding small molecule binding oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity 3-hydroxyanthranilate 3,4-dioxygenase activity dioxygenase activity	oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process quinolinate biosynthetic process organic substance metabolic process organic substance biosynthetic process pyridine-containing compound metabolic process small molecule metabolic process dicarboxylic acid biosynthetic process quinolinate metabolic process organonitrogen compound metabolic process oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process quinolinate biosynthetic process organic substance metabolic process organic substance biosynthetic process pyridine-containing compound metabolic process small molecule metabolic process dicarboxylic acid biosynthetic process quinolinate metabolic process organonitrogen compound metabolic process small molecule biosynthetic process cellular metabolic process dicarboxylic acid metabolic process pyridine-containing compound biosynthetic process carboxylic acid metabolic process organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process benzene-containing compound metabolic process aromatic amino acid metabolic process amino acid metabolic process primary metabolic process anthranilate metabolic process monocarboxylic acid metabolic process catabolic process aromatic amino acid family catabolic process indole-containing compound metabolic process organic acid catabolic process alpha-amino acid metabolic process cellular catabolic process carboxylic acid catabolic process indolalkylamine metabolic process amino acid catabolic process organonitrogen compound catabolic process organic cyclic compound catabolic process tryptophan metabolic process amine metabolic process alpha-amino acid catabolic process indole-containing compound catabolic process tryptophan catabolic process small molecule catabolic process organic substance catabolic process biogenic amine metabolic process nucleotide biosynthetic process nucleobase-containing compound metabolic process phosphate-containing compound metabolic process phosphorus metabolic process pyridine nucleotide metabolic process NAD biosynthetic process pyridine nucleotide biosynthetic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process nucleotide metabolic process nicotinamide nucleotide biosynthetic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process purine nucleotide biosynthetic process NAD metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process 'de novo' NAD biosynthetic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process organophosphate metabolic process 'de novo' NAD biosynthetic process from tryptophan	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR010329	3-hydroxyanthranilic acid dioxygenase	Family
A, B	IPR011051	RmlC-like cupin domain superfamily	Homologous Superfamily
A, B	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.