1ZRO

Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1zroa1	All alpha proteins	Duffy binding domain-like	Duffy binding domain-like	Duffy binding domain	Erythrocyte binding antigen region II	malaria parasite P. falciparum (Plasmodium falciparum ) [TaxId: 5833 ],	SCOPe (2.08)
B	d1zrob1	All alpha proteins	Duffy binding domain-like	Duffy binding domain-like	Duffy binding domain	Erythrocyte binding antigen region II	malaria parasite P. falciparum (Plasmodium falciparum ) [TaxId: 5833 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Duffy binding domain	8023790	4001588	SCOP2 (2022-06-29)
A	SCOP2 Family	Duffy binding domain	8023791	4001588	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Duffy binding domain-like	8036170	3001914	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Duffy binding domain-like	8036171	3001914	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Duffy binding domain-like	8036171	3001914	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Duffy binding domain-like	8036170	3001914	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05424	e1zroA1	A: alpha bundles	X: Duffy-binding-like domain, N-terminal subdomain (From Topology)	H: Duffy-binding-like domain, N-terminal subdomain (From Topology)	T: Duffy-binding-like domain, N-terminal subdomain	F: PF05424	ECOD (1.6)
A	F_UNCLASSIFIED	e1zroA4	A: alpha bundles	X: Duffy-binding-like domain, C-terminal subdomain (From Topology)	H: Duffy-binding-like domain, C-terminal subdomain (From Topology)	T: Duffy-binding-like domain, C-terminal subdomain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF03011	e1zroA3	A: alpha bundles	X: Duffy-binding-like domain, C-terminal subdomain (From Topology)	H: Duffy-binding-like domain, C-terminal subdomain (From Topology)	T: Duffy-binding-like domain, C-terminal subdomain	F: PF03011	ECOD (1.6)
B	PF05424	e1zroB2	A: alpha bundles	X: Duffy-binding-like domain, N-terminal subdomain (From Topology)	H: Duffy-binding-like domain, N-terminal subdomain (From Topology)	T: Duffy-binding-like domain, N-terminal subdomain	F: PF05424	ECOD (1.6)
B	F_UNCLASSIFIED	e1zroB1	A: alpha bundles	X: Duffy-binding-like domain, C-terminal subdomain (From Topology)	H: Duffy-binding-like domain, C-terminal subdomain (From Topology)	T: Duffy-binding-like domain, C-terminal subdomain	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.1660	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
B	1.10.287.1660	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05424	Duffy binding domain (Duffy_binding)	Duffy binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	erythrocyte binding antigen region II	host cell surface binding binding host cell surface receptor binding	-	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR008602	Duffy-antigen binding domain	Domain
A, B	IPR042202	Duffy-antigen binding superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.