1ZPS

Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1zpsa1	All beta proteins	HisI-like	HisI-like	HisI-like	Phosphoribosyl-AMP cyclohydrolase HisI	(Methanothermobacter thermautotrophicus ) [TaxId: 145262 ],	SCOPe (2.08)
B	d1zpsb_	All beta proteins	HisI-like	HisI-like	HisI-like	Phosphoribosyl-AMP cyclohydrolase HisI	(Methanothermobacter thermautotrophicus ) [TaxId: 145262 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	HisI-like	8023734	4002257	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	HisI-like	8036114	3001011	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	HisI-like	8036114	3001011	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01502	e1zpsA1	A: beta barrels	X: Ribosomal protein L25-like	H: HisI-like (From Topology)	T: HisI-like	F: PF01502	ECOD (1.6)
B	PF01502	e1zpsB1	A: beta barrels	X: Ribosomal protein L25-like	H: HisI-like (From Topology)	T: HisI-like	F: PF01502	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.810	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphoribosyl-AMP cyclohydrolase	CATH (4.3.0)
A	4.10.80.70	Few Secondary Structures	Irregular	Rhinovirus 14, subunit 4		CATH (4.3.0)
B	3.10.20.810	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphoribosyl-AMP cyclohydrolase	CATH (4.3.0)
B	4.10.80.70	Few Secondary Structures	Irregular	Rhinovirus 14, subunit 4		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01502	Phosphoribosyl-AMP cyclohydrolase (PRA-CH)	Phosphoribosyl-AMP cyclohydrolase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Phosphoribosyl-AMP cyclohydrolase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines phosphoribosyl-AMP cyclohydrolase activity cyclohydrolase activity hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds transition metal ion binding zinc ion binding	organonitrogen compound metabolic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process small molecule metabolic process organonitrogen compound metabolic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process small molecule metabolic process metabolic process cellular process histidine metabolic process histidine biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002496	Phosphoribosyl-AMP cyclohydrolase domain	Domain
A, B	IPR038019	Phosphoribosyl-AMP cyclohydrolase domain superfamily	Homologous Superfamily
A, B	IPR026660	Phosphoribosyl-AMP cyclohydrolase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.