1ZOQ

IRF3-CBP complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth C]	d1zoqc_	All alpha proteins	Nuclear receptor coactivator interlocking domain	Nuclear receptor coactivator interlocking domain	Nuclear receptor coactivator interlocking domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1zoqd_	All alpha proteins	Nuclear receptor coactivator interlocking domain	Nuclear receptor coactivator interlocking domain	Nuclear receptor coactivator interlocking domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SMAD/FHA domain-like	8003522	3000137	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	SMAD/FHA domain-like	8003522	3000137	SCOP2B (2022-06-29)
B [auth C]	SCOP2 Family	CREB-binding protein SRC1 interaction domain-like	8023716	4007726	SCOP2 (2022-06-29)
B [auth C]	SCOP2 Superfamily	Nuclear receptor coactivator interlocking domain-like	8036096	3001919	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Nuclear receptor coactivator interlocking domain-like	8036096	3001919	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IRF-3	e1zoqA3	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: IRF-3	ECOD (1.6)
C [auth B]	IRF-3	e1zoqB2	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: IRF-3	ECOD (1.6)
B [auth C]	Creb_binding	e1zoqC1	A: alpha arrays	X: Nuclear receptor coactivator CBP/p300 ibid domain (From Topology)	H: Nuclear receptor coactivator CBP/p300 ibid domain (From Topology)	T: Nuclear receptor coactivator CBP/p300 ibid domain	F: Creb_binding	ECOD (1.6)
D	Creb_binding	e1zoqD1	A: alpha arrays	X: Nuclear receptor coactivator CBP/p300 ibid domain (From Topology)	H: Nuclear receptor coactivator CBP/p300 ibid domain (From Topology)	T: Nuclear receptor coactivator CBP/p300 ibid domain	F: Creb_binding	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.200.10	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)
C [auth B]	2.60.200.10	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)
B [auth C]	1.10.1630.10	Mainly Alpha	Orthogonal Bundle	Creb-binding Protein	Chain: A	CATH (4.3.0)
D	1.10.1630.10	Mainly Alpha	Orthogonal Bundle	Creb-binding Protein	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B]	PF10401	Interferon-regulatory factor 3 (IRF-3)	Interferon-regulatory factor 3	-	Family
B [auth C], D	PF09030	Creb binding (Creb_binding)	Creb binding	The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and ...	The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B]	Interferon regulatory factor 3	sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity sequence-specific double-stranded DNA binding double-stranded DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity sequence-specific double-stranded DNA binding double-stranded DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding protein binding protein domain specific binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein homodimerization activity protein dimerization activity	cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus cell communication cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response cellular process activation of immune response cellular response to stress DNA damage response apoptotic process cell death programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of cell communication response to organic substance positive regulation of signal transduction regulation of type I interferon-mediated signaling pathway response to cytokine regulation of signal transduction interferon-mediated signaling pathway cellular response to type I interferon cellular response to cytokine stimulus regulation of response to cytokine stimulus response to chemical response to type I interferon positive regulation of type I interferon-mediated signaling pathway positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cellular response to organic substance positive regulation of cellular process regulation of signaling cell surface receptor signaling pathway regulation of cytokine-mediated signaling pathway cellular response to chemical stimulus type I interferon-mediated signaling pathway regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression mRNA transcription mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process organic cyclic compound metabolic process DNA-templated transcription nucleic acid biosynthetic process organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process MDA-5 signaling pathway defense response to virus response to virus multicellular organismal process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process regulation of biosynthetic process positive regulation of type I interferon production type I interferon production regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process regulation of type I interferon production regulation of primary metabolic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription regulation of RNA biosynthetic process positive regulation of RNA biosynthetic process interferon-alpha production regulation of interferon-alpha production positive regulation of interferon-alpha production positive regulation of canonical NF-kappaB signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction immune response-regulating cell surface receptor signaling pathway cell surface toll-like receptor signaling pathway immune response-activating cell surface receptor signaling pathway innate immune response activating cell surface receptor signaling pathway cell surface pattern recognition receptor signaling pathway toll-like receptor 4 signaling pathway response to lipid cellular response to lipopolysaccharide lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus response to bacterium response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to lipid response to molecule of bacterial origin cellular response to nitrogen compound cellular response to dsRNA cellular response to exogenous dsRNA cellular response to organic cyclic compound response to dsRNA response to nitrogen compound response to exogenous dsRNA response to organic cyclic compound toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway regulation of interferon-beta production interferon-beta production positive regulation of interferon-beta production antiviral innate immune response regulation of inflammatory response inflammatory response programmed necrotic cell death macrophage apoptotic process myeloid cell apoptotic process leukocyte apoptotic process inflammatory cell apoptotic process cellular response to virus	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle mitochondrion intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle mitochondrion intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B [auth C], D	CREB-binding protein	transcription factor binding protein binding binding bHLH transcription factor binding DNA-binding transcription factor binding MRF binding acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity catalytic activity, acting on a protein N-acetyltransferase activity histone H3 acetyltransferase activity transcription factor binding protein binding binding bHLH transcription factor binding DNA-binding transcription factor binding MRF binding acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity catalytic activity, acting on a protein N-acetyltransferase activity histone H3 acetyltransferase activity peptide N-acetyltransferase activity histone H3K27 acetyltransferase activity histone acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity N-acyltransferase activity p53 binding RNA polymerase II-specific DNA-binding transcription factor binding protein-containing complex binding chromatin binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding organic cyclic compound binding damaged DNA binding nucleic acid binding histone H3K18 acetyltransferase activity transcription corepressor activity transcription coregulator binding transcription coactivator binding chromatin DNA binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	protein destabilization regulation of protein stability biological regulation regulation of biological quality cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular process regulation of biological process regulation of cellular process signaling non-canonical NF-kappaB signal transduction intracellular signal transduction protein destabilization regulation of protein stability biological regulation regulation of biological quality cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular process regulation of biological process regulation of cellular process signaling non-canonical NF-kappaB signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process response to decreased oxygen levels response to hypoxia response to stress response to oxygen levels response to abiotic stimulus negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process cellular response to heat regulation of cellular response to heat regulation of cellular response to stress response to heat response to temperature stimulus cellular response to stress regulation of response to stimulus regulation of response to stress cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis protein localization regulation of localization cellular localization regulation of protein localization positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway positive regulation of signal transduction cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction regulation of transforming growth factor beta receptor signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway positive regulation of signaling smoothened signaling pathway regulation of smoothened signaling pathway peptidyl-lysine acetylation N-terminal peptidyl-lysine acetylation peptidyl-lysine modification protein acylation protein maturation peptidyl-amino acid modification N-terminal protein amino acid acetylation protein metabolic process protein modification process organonitrogen compound metabolic process protein acetylation N-terminal protein amino acid modification macromolecule modification positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway response to biotic stimulus immune response-activating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway immune response response to other organism immune response-activating cell surface receptor signaling pathway regulation of innate immune response response to external stimulus response to lectin defense response to other organism cellular response to lectin positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus innate immune response activating cell surface receptor signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway innate immune response response to external biotic stimulus positive regulation of innate immune response defense response defense response to symbiont stimulatory C-type lectin receptor signaling pathway immune system process rhythmic process response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation cellular response to abiotic stimulus cellular response to UV homeostatic process transcription by RNA polymerase I regulation of transcription by RNA polymerase I negative regulation of transcription by RNA polymerase I developmental process multicellular organismal process limb development appendage development embryonic limb morphogenesis embryonic morphogenesis embryonic appendage morphogenesis embryo development multicellular organism development anatomical structure morphogenesis appendage morphogenesis anatomical structure development embryonic digit morphogenesis limb morphogenesis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex transcription regulator complex intracellular organelle protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle catalytic complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex transcription regulator complex intracellular organelle protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle catalytic complex transferase complex histone acetyltransferase complex acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen nuclear body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR019817	Interferon regulatory factor, conserved site	Conserved Site
A, C [auth B]	IPR019471	Interferon regulatory factor-3	Domain
A, C [auth B]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, C [auth B]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, C [auth B]	IPR017855	SMAD-like domain superfamily	Homologous Superfamily
A, C [auth B]	IPR001346	Interferon regulatory factor, DNA-binding domain	Domain
A, C [auth B]	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
B [auth C], D	IPR043145	Zinc finger, ZZ-type superfamily	Homologous Superfamily
B [auth C], D	IPR018359	Bromodomain, conserved site	Conserved Site
B [auth C], D	IPR036529	Coactivator CBP, KIX domain superfamily	Homologous Superfamily
B [auth C], D	IPR009110	Nuclear receptor coactivator, interlocking	Homologous Superfamily
B [auth C], D	IPR000197	Zinc finger, TAZ-type	Domain
B [auth C], D	IPR000433	Zinc finger, ZZ-type	Domain
B [auth C], D	IPR003101	Coactivator CBP, KIX domain	Domain
B [auth C], D	IPR013178	Histone acetyltransferase Rtt109/CBP	Family
B [auth C], D	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
B [auth C], D	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
B [auth C], D	IPR010303	CREB-binding protein/p300, atypical RING domain	Domain
B [auth C], D	IPR001487	Bromodomain	Domain
B [auth C], D	IPR035898	TAZ domain superfamily	Homologous Superfamily
B [auth C], D	IPR037073	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily	Homologous Superfamily
B [auth C], D	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking	Domain
B [auth C], D	IPR038547	CBP/p300, atypical RING domain superfamily	Homologous Superfamily
B [auth C], D	IPR031162	CBP/p300-type histone acetyltransferase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C [auth B]	Pharos: Q14653	herpes simplex encephalitis, susceptibility to, 7 Hashimoto thyroiditis Hodgkins lymphoma microphthalmia with limb anomalies rheumatoid arthritis systemic sclerosis Herpes encephalitis hypothyroidism myositis skin basal cell carcinoma vitiligo herpes simplex encephalitis influenza pancreatic ductal adenocarcinoma systemic lupus erythematosus
B [auth C], D	Pharos: Q92793	Rubinstein-Taybi syndrome transitional cell carcinoma urinary bladder cancer esophageal squamous cell carcinoma follicular lymphoma adenoid cystic carcinoma Rubinstein-Taybi syndrome due to CREBBP mutations Sezary syndrome small cell lung carcinoma prostate cancer salivary gland adenoid cystic carcinoma squamous cell carcinoma Rubinstein-Taybi syndrome due to 16p13.3 microdeletion amyotrophic lateral sclerosis type 1 Lymphoma, Large-Cell, Follicular Rubinstein-Taybi syndrome transitional cell carcinoma urinary bladder cancer esophageal squamous cell carcinoma follicular lymphoma adenoid cystic carcinoma Rubinstein-Taybi syndrome due to CREBBP mutations Sezary syndrome small cell lung carcinoma prostate cancer salivary gland adenoid cystic carcinoma squamous cell carcinoma Rubinstein-Taybi syndrome due to 16p13.3 microdeletion amyotrophic lateral sclerosis type 1 Lymphoma, Large-Cell, Follicular non-Hodgkin lymphoma ovarian cancer acute myeloid leukemia cancer endogenous depression intellectual disability osteogenesis imperfecta plasma cell myeloma acute myeloid leukemia with t(8;16)(p11;p13) translocation small cell carcinoma astrocytic tumor cleft lip lung adenocarcinoma osteosarcoma schizophrenia bipolar disorder subependymal giant cell astrocytoma diffuse large B-cell lymphoma urinary bladder neoplasm