Annotations: 1ZMZ

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13499	e1zmzA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Centrin-2	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein-containing complex binding heterotrimeric G-protein binding cytoskeletal protein binding microtubule binding protein binding tubulin binding G-protein beta/gamma-subunit complex binding	cellular process cell cycle mitotic cell cycle developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation RNA transport nitrogen compound transport transport cellular process cell cycle mitotic cell cycle developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cell division protein localization establishment of protein localization cellular localization protein transport cellular macromolecule localization centriole assembly microtubule organizing center organization organelle assembly non-membrane-bounded organelle assembly microtubule cytoskeleton organization cellular component organization cellular component biogenesis centrosome duplication organelle organization cellular component assembly centrosome cycle microtubule-based process cellular component organization or biogenesis cytoskeleton organization centriole replication cell cycle process regulation of cytokinesis regulation of biological process regulation of cellular process regulation of cell cycle process biological regulation cytokinesis regulation of cell division regulation of cell cycle cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress metabolic process macromolecule metabolic process DNA repair	apical part of cell cellular anatomical entity membrane-bounded organelle ciliary transition zone non-motile cilium 9+0 non-motile cilium cilium neuron projection plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle photoreceptor connecting cilium intracellular organelle apical part of cell cellular anatomical entity membrane-bounded organelle ciliary transition zone non-motile cilium 9+0 non-motile cilium cilium neuron projection plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle photoreceptor connecting cilium intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle centriole cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex nuclear protein-containing complex endomembrane system organelle envelope nuclear envelope nuclear pore nuclear basket nuclear pore XPC complex nucleotide-excision repair complex transcription export complex 2 9+2 motile cilium motile cilium ciliary basal body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site	Conserved Site
A	IPR002048	EF-hand domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P41208	breast cancer malignant ependymoma sinusitis dermatomyositis nasopharyngeal carcinoma xeroderma pigmentosum large cell medulloblastoma ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.