1ZE3

Crystal Structure of the Ternary Complex of FIMD (N-Terminal Domain) with FIMC and the Pilin Domain of FIMH

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth C]	d1ze3c1	All beta proteins	Immunoglobulin-like beta-sandwich	PapD-like	Pilus chaperone	Periplasmic chaperone FimC	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A [auth C]	d1ze3c2	All beta proteins	C2 domain-like	Periplasmic chaperone C-domain	Periplasmic chaperone C-domain	FimC	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B [auth H]	d1ze3h_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	Bacterial adhesins	Pilus subunits	Mannose-specific adhesin FimH, C-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C [auth D]	d1ze3d1	All beta proteins	FimD N-terminal domain-like	FimD N-terminal domain-like	Usher N-domain	Outer membrane usher protein FimD	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth C]	SCOP2 Family	Pilus chaperone	8055314	4007561	SCOP2 (2022-06-29)
A [auth C]	SCOP2 Family	Periplasmic chaperone C-domain	8023285	4002248	SCOP2 (2022-06-29)
A [auth C]	SCOP2 Superfamily	PapD-like	8055315	3002067	SCOP2 (2022-06-29)
A [auth C]	SCOP2 Superfamily	Periplasmic chaperone C-domain	8035665	3000998	SCOP2 (2022-06-29)
C [auth D]	SCOP2B Superfamily	FimD/Slr0280 N-terminal domain-like	8039575	3001001	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	PapD_C	e1ze3C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PapD_C	ECOD (1.6)
A [auth C]	PapD_N	e1ze3C2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PapD_N	ECOD (1.6)
B [auth H]	Fimbrial_1	e1ze3H1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Fimbrial_1	ECOD (1.6)
C [auth D]	PapC_N	e1ze3D1	A: beta barrels	X: FimD N-terminal domain-like	H: FimD N-terminal domain-like (From Topology)	T: FimD N-terminal domain-like	F: PapC_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth C]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B [auth H]	2.60.40.1090	Mainly Beta	Sandwich	Immunoglobulin-like	Fimbrial-type adhesion domain	CATH (4.3.0)
C [auth D]	3.10.20.410	Alpha Beta	Roll	Ubiquitin-like (UB roll)	PapC, N-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C]	PF02753	Pili assembly chaperone PapD, C-terminal domain (PapD_C)	Pili assembly chaperone PapD, C-terminal domain	Ig-like beta-sandwich fold. This domain is the C-terminal part of the pilus and flagellar-assembly chaperone protein PapD.	Domain
A [auth C]	PF00345	Pili and flagellar-assembly chaperone, PapD N-terminal domain (PapD_N)	Pili and flagellar-assembly chaperone, PapD N-terminal domain	C2 domain-like beta-sandwich fold. This domain is the n-terminal part of the PapD chaperone protein for pilus and flagellar assembly.	Domain
B [auth H]	PF00419	Fimbrial protein (Fimbrial)	Fimbrial protein	-	Domain
C [auth D]	PF13954	PapC N-terminal domain (PapC_N)	PapC N-terminal domain	The PapC N-terminal domain is a structural domain found at the N-terminus of the E. coli PapC protein. Pili are assembled using the chaperone usher system. In E.coli this is composed of the chaperone PapD and the usher PapC. This domain represents th ...	The PapC N-terminal domain is a structural domain found at the N-terminus of the E. coli PapC protein. Pili are assembled using the chaperone usher system. In E.coli this is composed of the chaperone PapD and the usher PapC. This domain represents the N-terminal domain from PapC and its homologues. This domain is involved in substrate binding [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	Chaperone protein fimC	protein folding chaperone	cellular component organization cell wall organization or biogenesis cell wall organization cellular process cellular component organization or biogenesis external encapsulating structure organization organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression chaperone-mediated protein folding macromolecule biosynthetic process protein maturation cellular component organization cell wall organization or biogenesis cell wall organization cellular process cellular component organization or biogenesis external encapsulating structure organization organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression chaperone-mediated protein folding macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process protein metabolic process macromolecule metabolic process	outer membrane-bounded periplasmic space cell envelope periplasmic space cellular anatomical entity
B [auth H]	FimH protein	binding mannose binding monosaccharide binding carbohydrate binding small molecule binding	behavior multicellular organismal process response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus mechanosensory behavior cell adhesion cell-substrate adhesion cellular process cell adhesion involved in biofilm formation cell aggregation biofilm formation biological process involved in intraspecies interaction between organisms behavior multicellular organismal process response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus mechanosensory behavior cell adhesion cell-substrate adhesion cellular process cell adhesion involved in biofilm formation cell aggregation biofilm formation biological process involved in intraspecies interaction between organisms single-species biofilm formation aggregation of unicellular organisms submerged biofilm formation cell adhesion involved in single-species biofilm formation single-species submerged biofilm formation	host cellular component host cell part host cell membrane cellular anatomical entity pilus cell projection pilus tip
C [auth D]	Outer membrane usher protein fimD	wide pore channel activity passive transmembrane transporter activity channel activity porin activity fimbrial usher porin activity transporter activity transmembrane transporter activity	cellular component biogenesis cellular component organization cellular component assembly cell projection organization cellular process pilus assembly cellular component organization or biogenesis pilus organization cell projection assembly	cell periphery cell outer membrane external encapsulating structure membrane cell envelope outer membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C]	IPR036316	Pili assembly chaperone, C-terminal domain superfamily	Homologous Superfamily
A [auth C]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth C]	IPR016148	Pili assembly chaperone, C-terminal	Domain
A [auth C]	IPR008962	PapD-like superfamily	Homologous Superfamily
A [auth C]	IPR016147	Pili assembly chaperone, N-terminal	Domain
A [auth C]	IPR001829	Pili assembly chaperone, bacterial	Family
A [auth C]	IPR018046	Pili assembly chaperone, conserved site	Conserved Site
B [auth H]	IPR000259	Fimbrial-type adhesion domain	Domain
B [auth H]	IPR036937	Fimbrial-type adhesion domain superfamily	Homologous Superfamily
B [auth H]	IPR015243	FimH, mannose-binding domain	Domain
B [auth H]	IPR008966	Adhesion domain superfamily	Homologous Superfamily
C [auth D]	IPR042186	Outer membrane usher protein FimD, plug domain	Homologous Superfamily
C [auth D]	IPR037224	PapC, N-terminal domain superfamily	Homologous Superfamily
C [auth D]	IPR018030	Fimbrial membrane usher, conserved site	Conserved Site
C [auth D]	IPR025885	PapC, N-terminal domain	Domain
C [auth D]	IPR043142	PapC-like, C-terminal domain superfamily	Homologous Superfamily
C [auth D]	IPR025949	PapC-like, C-terminal domain	Domain
C [auth D]	IPR000015	Outer membrane usher protein	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.