1ZE2

Conformational change of pseudouridine 55 synthase upon its association with RNA substrate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d1ze2a1	All beta proteins	PUA domain-like	PUA domain-like	PUA domain	Pseudouridine synthase II TruB, C-terminal domain	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
C [auth A]	d1ze2a2	Alpha and beta proteins (a+b)	Pseudouridine synthase	Pseudouridine synthase	Pseudouridine synthase II TruB	Pseudouridine synthase II TruB	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
D [auth B]	d1ze2b1	All beta proteins	PUA domain-like	PUA domain-like	PUA domain	Pseudouridine synthase II TruB, C-terminal domain	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
D [auth B]	d1ze2b2	Alpha and beta proteins (a+b)	Pseudouridine synthase	Pseudouridine synthase	Pseudouridine synthase II TruB	Pseudouridine synthase II TruB	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2B Superfamily	PUA domain-like	8040283	3001015	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	Pseudouridine synthase	8040284	3001360	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	PF01472	e1ze2A1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PUA domain	F: PF01472	ECOD (1.6)
C [auth A]	PF01509,PF16198	e1ze2A2	A: a+b two layers	X: Alpha-beta plaits	H: Pseudouridine synthase (From Topology)	T: Pseudouridine synthase	F: PF01509,PF16198	ECOD (1.6)
D [auth B]	PF01472	e1ze2B6	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PUA domain	F: PF01472	ECOD (1.6)
D [auth B]	PF01509	e1ze2B5	A: a+b two layers	X: Alpha-beta plaits	H: Pseudouridine synthase (From Topology)	T: Pseudouridine synthase	F: PF01509	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	3.30.2350.10	Alpha Beta	2-Layer Sandwich	Pseudouridine synthase	Pseudouridine synthase	CATH (4.3.0)
C [auth A]	2.30.130.10	Mainly Beta	Roll	Archaeosine Trna-guanine Transglycosylase	Chain: A, domain 4	CATH (4.3.0)
D [auth B]	2.30.130.10	Mainly Beta	Roll	Archaeosine Trna-guanine Transglycosylase	Chain: A, domain 4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], D [auth B]	PF16198	tRNA pseudouridylate synthase B C-terminal domain (TruB_C_2)	tRNA pseudouridylate synthase B C-terminal domain	-	Family
C [auth A], D [auth B]	PF01509	TruB family pseudouridylate synthase (N terminal domain) (TruB_N)	TruB family pseudouridylate synthase (N terminal domain)	-	Family
C [auth A], D [auth B]	PF01472	PUA domain (PUA)	PUA domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth D]	5'-R(GPGPCPCPAPCPGPGPUP(FHU)PCPGPAPAPUPCPCPGPUPGPGPC)-3'	-	-	-
C [auth A], D [auth B]	tRNA pseudouridine synthase B	isomerase activity pseudouridine synthase activity catalytic activity intramolecular transferase activity tRNA pseudouridine synthase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid catalytic activity, acting on a tRNA RNA binding binding organic cyclic compound binding nucleic acid binding	cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing cellular metabolic process tRNA modification primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing cellular metabolic process tRNA modification primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process RNA modification biosynthetic process ncRNA metabolic process macromolecule modification nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process pseudouridine synthesis mRNA modification mRNA metabolic process mRNA pseudouridine synthesis tRNA pseudouridine synthesis	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], D [auth B]	IPR015947	PUA-like superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR020103	Pseudouridine synthase, catalytic domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR002501	Pseudouridine synthase II, N-terminal	Domain
C [auth A], D [auth B]	IPR032819	tRNA pseudouridylate synthase B, C-terminal	Domain
C [auth A], D [auth B]	IPR036974	PUA domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR014780	tRNA pseudouridine synthase II, TruB	Family
C [auth A], D [auth B]	IPR002478	PUA domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.