1Z7X
X-ray structure of human ribonuclease inhibitor complexed with ribonuclease I
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth X] | d1z7xx_ | Alpha and beta proteins (a+b) | RNase A-like | RNase A-like | Ribonuclease A-like | Ribonuclease A (also ribonuclease B, S) | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
C [auth Z] | d1z7xz_ | Alpha and beta proteins (a+b) | RNase A-like | RNase A-like | Ribonuclease A-like | Ribonuclease A (also ribonuclease B, S) | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B [auth W] | d1z7xw_ | Alpha and beta proteins (a/b) | Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) | RNI-like | 28-residue LRR | automated matches | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
D [auth Y] | d1z7xy_ | Alpha and beta proteins (a/b) | Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) | RNI-like | 28-residue LRR | automated matches | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A [auth X] | SCOP2 Family | Ribonuclease A-like | 8022973 | 4000894 | SCOP2 (2022-06-29) |
A [auth X] | SCOP2 Superfamily | RNase A-like | 8035353 | 3001918 | SCOP2 (2022-06-29) |
C [auth Z] | SCOP2B Superfamily | RNase A-like | 8035353 | 3001918 | SCOP2B (2022-06-29) |
B [auth W] | SCOP2 Family | 28-residue LRR | 8022972 | 4003523 | SCOP2 (2022-06-29) |
B [auth W] | SCOP2 Superfamily | RNI-like | 8035352 | 3000990 | SCOP2 (2022-06-29) |
D [auth Y] | SCOP2B Superfamily | RNI-like | 8035352 | 3000990 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth X] | PF00074 | e1z7xX1 | A: a+b complex topology | X: RNase A-like | H: RNase A-like (From Topology) | T: RNase A-like | F: PF00074 | ECOD (1.6) |
C [auth Z] | PF00074 | e1z7xZ1 | A: a+b complex topology | X: RNase A-like | H: RNase A-like (From Topology) | T: RNase A-like | F: PF00074 | ECOD (1.6) |
B [auth W] | PF13516,PF18779 | e1z7xW1 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: PF13516,PF18779 | ECOD (1.6) |
D [auth Y] | PF13516,PF18779 | e1z7xY1 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: PF13516,PF18779 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A [auth X] | 3.10.130.10 | Alpha Beta | Roll | P-30 Protein | Ribonuclease A-like domain | CATH (4.3.0) |
C [auth Z] | 3.10.130.10 | Alpha Beta | Roll | P-30 Protein | Ribonuclease A-like domain | CATH (4.3.0) |
B [auth W] | 3.80.10.10 | Alpha Beta | Alpha-Beta Horseshoe | Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) | Ribonuclease Inhibitor | CATH (4.3.0) |
D [auth Y] | 3.80.10.10 | Alpha Beta | Alpha-Beta Horseshoe | Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) | Ribonuclease Inhibitor | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth X], C [auth Z] | PF00074 | Pancreatic ribonuclease (RnaseA) | Pancreatic ribonuclease | Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices. | Domain |
B [auth W], D [auth Y] | PF13516 | Leucine Rich repeat (LRR_6) | Leucine Rich repeat | - | Repeat |
B [auth W], D [auth Y] | PF18779 | Capping Ribonuclease inhibitor Leucine Rich Repeat (LRR_RI_capping) | Capping Ribonuclease inhibitor Leucine Rich Repeat | - | Repeat |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A [auth X], C [auth Z] | IPR023412 | Ribonuclease A-domain | Domain |
A [auth X], C [auth Z] | IPR036816 | Ribonuclease A-like domain superfamily | Homologous Superfamily |
A [auth X], C [auth Z] | IPR001427 | Pancreatic ribonuclease | Family |
A [auth X], C [auth Z] | IPR023411 | Ribonuclease A, active site | Active Site |
B [auth W], D [auth Y] | IPR001611 | Leucine-rich repeat | Repeat |
B [auth W], D [auth Y] | IPR032675 | Leucine-rich repeat domain superfamily | Homologous Superfamily |
B [auth W], D [auth Y] | IPR041302 | Ribonuclease inhibitor, leucine rich repeat cap | Repeat |
B [auth W], D [auth Y] | IPR006553 | Leucine-rich repeat, cysteine-containing subtype | Repeat |