Annotations: 1Z6C

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EGF_CA	e1z6cA2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: EGF_CA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07645	Calcium-binding EGF domain (EGF_CA)	Calcium-binding EGF domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Vitamin K-dependent protein S	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity	multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding regulation of response to external stimulus negative regulation of biological process regulation of response to wounding multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding regulation of response to external stimulus negative regulation of biological process regulation of response to wounding regulation of coagulation regulation of response to stress regulation of multicellular organismal process regulation of hemostasis regulation of biological process negative regulation of response to stimulus negative regulation of wound healing regulation of blood coagulation negative regulation of blood coagulation response to external stimulus negative regulation of response to wounding negative regulation of hemostasis fibrinolysis negative regulation of coagulation regulation of response to stimulus negative regulation of response to external stimulus regulation of wound healing negative regulation of multicellular organismal process	membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle organelle lumen organelle cytoplasm extracellular region membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle organelle lumen organelle cytoplasm extracellular region extracellular space blood microparticle Golgi membrane membrane bounding membrane of organelle organelle membrane extracellular exosome extracellular vesicle extracellular organelle vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle cytoplasmic vesicle lumen secretory granule lumen cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule platelet alpha granule lumen cell periphery plasma membrane organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001791	Laminin G domain	Domain
A	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain	Domain
A	IPR017857	Coagulation factor-like, Gla domain superfamily	Homologous Superfamily
A	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR035972	Gamma-carboxyglutamic acid-rich (GLA) domain superfamily	Homologous Superfamily
A	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A	IPR001881	EGF-like calcium-binding domain	Domain
A	IPR013032	EGF-like, conserved site	Conserved Site
A	IPR000742	EGF-like domain	Domain
A	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P07225	thrombophilia due to protein S deficiency, autosomal dominant sagittal sinus thrombosis thrombophilia due to protein S deficiency, autosomal recessive Thromboembolism adult acute respiratory distress syndrome thrombophilia juvenile idiopathic arthritis protein S deficiency thrombophilia due to activated protein C resistance vitamin K deficiency hemorrhagic disease lung cancer malignant glioma non-small cell lung carcinoma pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor thrombophilia due to protein S deficiency, autosomal dominant sagittal sinus thrombosis thrombophilia due to protein S deficiency, autosomal recessive Thromboembolism adult acute respiratory distress syndrome thrombophilia juvenile idiopathic arthritis protein S deficiency thrombophilia due to activated protein C resistance vitamin K deficiency hemorrhagic disease lung cancer malignant glioma non-small cell lung carcinoma pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor sinusitis colorectal cancer Duchenne muscular dystrophy gastric carcinoma IgA glomerulonephritis lung carcinoma malignant pancreatic neoplasm oligodendroglioma pilocytic astrocytoma breast cancer spondyloarthropathy cystic fibrosis exocrine pancreatic carcinoma glioblastoma interstitial cystitis tuberculosis lung adenocarcinoma malignant ependymoma MALT lymphoma ovarian cancer astrocytic tumor breast carcinoma subependymal giant cell astrocytoma dermatomyositis gastric cancer hereditary thrombophilia due to congenital protein S deficiency invasive ductal breast carcinoma thrombotic disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.