Annotations: 1YW5

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	WW	e1yw5A4	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: WW	ECOD (1.6)
A	Rotamase_3	e1yw5A3	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: Rotamase_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.20.70.10	Mainly Beta	Single Sheet	Ubiquitin Ligase Nedd4	Chain: W	CATH (4.3.0)
A	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00639	PPIC-type PPIASE domain (Rotamase)	PPIC-type PPIASE domain	Rotamases increase the rate of protein folding by catalysing the interconversion of cis-proline and trans-proline.	Domain
A	PF00397	WW domain (WW)	WW domain	The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	peptidyl prolyl cis/trans isomerase	isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity basal transcription machinery binding RNA polymerase binding protein binding binding RNA polymerase II complex binding basal RNA polymerase II transcription machinery binding RNA polymerase core enzyme binding enzyme binding	cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress cellular process response to starvation cellular response to starvation growth filamentous growth of a population of unicellular organisms in response to starvation filamentous growth filamentous growth of a population of unicellular organisms cellular biosynthetic process cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress cellular process response to starvation cellular response to starvation growth filamentous growth of a population of unicellular organisms in response to starvation filamentous growth filamentous growth of a population of unicellular organisms cellular biosynthetic process RNA metabolic process DNA-templated transcription termination RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process macromolecule metabolic process termination of RNA polymerase II transcription cellular response to heat response to heat response to abiotic stimulus response to temperature stimulus filamentous growth of a population of unicellular organisms in response to biotic stimulus response to biotic stimulus catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process negative regulation of biological process regulation of ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of primary metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis protein metabolic process negative regulation of protein metabolic process negative regulation of ubiquitin-dependent protein catabolic process negative regulation of macromolecule metabolic process organonitrogen compound catabolic process negative regulation of catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process biological regulation regulation of catabolic process regulation of macromolecule metabolic process protein catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process organic substance catabolic process filamentous growth of a population of unicellular organisms in response to heat regulation of cellular process transcription preinitiation complex assembly positive regulation of macromolecule biosynthetic process cellular component biogenesis positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression RNA polymerase II preinitiation complex assembly regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization positive regulation of cellular component organization positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process cellular component organization protein-DNA complex organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of biosynthetic process protein-containing complex assembly cellular component organization or biogenesis positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II protein-DNA complex assembly regulation of cellular component biogenesis DNA-templated transcription initiation regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II positive regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of biosynthetic process positive regulation of organelle organization regulation of rDNA heterochromatin formation chromatin organization rDNA heterochromatin formation regulation of heterochromatin formation regulation of chromatin organization regulation of chromosome organization regulation of organelle organization positive regulation of chromosome organization negative regulation of gene expression nucleolus organization negative regulation of gene expression, epigenetic nucleolar chromatin organization positive regulation of heterochromatin formation chromatin remodeling positive regulation of chromatin organization heterochromatin formation epigenetic regulation of gene expression chromosome organization nucleus organization organelle organization positive regulation of rDNA heterochromatin formation facultative heterochromatin formation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery extracellular matrix biofilm matrix external encapsulating structure fungal biofilm matrix membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
A	IPR036020	WW domain superfamily	Homologous Superfamily
A	IPR000297	Peptidyl-prolyl cis-trans isomerase, PpiC-type	Domain
A	IPR001202	WW domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.