1YVL

Structure of Unphosphorylated STAT1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Transcription factor STAT-4 N-domain	8081063	3000825	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	STAT	8037577	3000357	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	p53-like transcription factors	8040239	3000758	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	STAT	8037577	3000357	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Transcription factor STAT-4 N-domain	8081063	3000825	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	p53-like transcription factors	8040239	3000758	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SH2 domain	8035702	3000197	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	STAT_bind_N	e1yvlA5	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: STAT_bind_N	ECOD (1.6)
A	STAT_bind_C	e1yvlA4	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: STAT_bind_C	ECOD (1.6)
A	STAT_int	e1yvlA9	A: alpha arrays	X: Transcription factor STAT-4 N-domain (From Topology)	H: Transcription factor STAT-4 N-domain (From Topology)	T: Transcription factor STAT-4 N-domain	F: STAT_int	ECOD (1.6)
A	STAT_alpha	e1yvlA2	A: alpha bundles	X: STAT-like	H: STAT (From Topology)	T: STAT	F: STAT_alpha	ECOD (1.6)
A	SH2	e1yvlA6	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)
B	STAT_bind_N	e1yvlB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: STAT_bind_N	ECOD (1.6)
B	STAT_bind_C	e1yvlB8	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: STAT_bind_C	ECOD (1.6)
B	STAT_int	e1yvlB9	A: alpha arrays	X: Transcription factor STAT-4 N-domain (From Topology)	H: Transcription factor STAT-4 N-domain (From Topology)	T: Transcription factor STAT-4 N-domain	F: STAT_int	ECOD (1.6)
B	STAT_alpha	e1yvlB7	A: alpha bundles	X: STAT-like	H: STAT (From Topology)	T: STAT	F: STAT_alpha	ECOD (1.6)
B	SH2	e1yvlB10	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.532.10	Mainly Alpha	Orthogonal Bundle	Transcription Factor, Stat-4	STAT transcription factor, N-terminal domain	CATH (4.3.0)
A	1.20.1050.20	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
A	2.60.40.630	Mainly Beta	Sandwich	Immunoglobulin-like	STAT transcription factor, DNA-binding domain	CATH (4.3.0)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
A	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
B	1.10.532.10	Mainly Alpha	Orthogonal Bundle	Transcription Factor, Stat-4	STAT transcription factor, N-terminal domain	CATH (4.3.0)
B	1.20.1050.20	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
B	2.60.40.630	Mainly Beta	Sandwich	Immunoglobulin-like	STAT transcription factor, DNA-binding domain	CATH (4.3.0)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00017	SH2 domain (SH2)	SH2 domain	-	Domain
A, B	PF21354	Signal transducer and activator of transcription, linker domain (STAT_linker)	Signal transducer and activator of transcription, linker domain	This domain is found in Signal transducer and activator of transcription proteins (STAT) from animals. These proteins are activated in response to extracellular signals such as cytokines, growth factors and hormonal factors and translocate to the nuc ...	This domain is found in Signal transducer and activator of transcription proteins (STAT) from animals. These proteins are activated in response to extracellular signals such as cytokines, growth factors and hormonal factors and translocate to the nucleus, where they bind to specific promoter sequences in target genes. This entry represents the all-helical linker domain that connects the DNA binding domain (Pfam:PF02864) and the SH2 domain (Pfam:PF00017) [1-5].	Domain
A, B	PF01017	STAT protein, all-alpha domain (STAT_alpha)	STAT protein, all-alpha domain	-	Family
A, B	PF02865	STAT protein, protein interaction domain (STAT_int)	STAT protein, protein interaction domain	STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STAT proteins also include an S ...	STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STAT proteins also include an SH2 domain Pfam:PF00017.	Domain
A, B	PF02864	STAT protein, DNA binding domain (STAT_bind)	STAT protein, DNA binding domain	STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. This family represents the DNA ...	STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. This family represents the DNA binding domain of STAT, which has an ig-like fold. STAT proteins also include an SH2 domain Pfam:PF00017.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Signal transducer and activator of transcription 1-alpha/beta	CCR5 chemokine receptor binding CCR chemokine receptor binding protein binding binding signaling receptor binding cytokine receptor binding G protein-coupled receptor binding chemokine receptor binding histone binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity CCR5 chemokine receptor binding CCR chemokine receptor binding protein binding binding signaling receptor binding cytokine receptor binding G protein-coupled receptor binding chemokine receptor binding histone binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity cell adhesion molecule binding cadherin binding DNA binding sequence-specific DNA binding double-stranded DNA binding core promoter sequence-specific DNA binding nucleic acid binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding identical protein binding transcription factor binding transcription coregulator binding transcription corepressor binding protein phosphatase binding phosphatase binding enzyme binding protein phosphatase 2A binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding ubiquitin-like protein ligase binding protein homodimerization activity protein dimerization activity transcription coactivator binding histone acetyltransferase binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor binding	response to stimulus response to chemical response to xenobiotic stimulus multicellular organismal process kidney epithelium development regulation of cellular process negative regulation of biological process regulation of kidney development metanephric nephron tubule epithelial cell differentiation regulation of cell differentiation epithelial cell differentiation regulation of epithelial cell differentiation multicellular organism development metanephros development response to stimulus response to chemical response to xenobiotic stimulus multicellular organismal process kidney epithelium development regulation of cellular process negative regulation of biological process regulation of kidney development metanephric nephron tubule epithelial cell differentiation regulation of cell differentiation epithelial cell differentiation regulation of epithelial cell differentiation multicellular organism development metanephros development cell differentiation anatomical structure development regulation of epithelial cell differentiation involved in kidney development regulation of nephron tubule epithelial cell differentiation nephron development system development developmental process epithelium development regulation of biological process metanephric nephron tubule development tissue development nephron tubule epithelial cell differentiation negative regulation of nephron tubule epithelial cell differentiation metanephric tubule development negative regulation of multicellular organismal process cellular developmental process regulation of developmental process negative regulation of epithelial cell differentiation involved in kidney development metanephric epithelium development nephron tubule development renal system development negative regulation of kidney development negative regulation of metanephric nephron tubule epithelial cell differentiation renal tubule development negative regulation of cellular process regulation of multicellular organismal process negative regulation of cell differentiation regulation of metanephric nephron tubule epithelial cell differentiation metanephric nephron epithelium development nephron epithelium development epithelial cell differentiation involved in kidney development regulation of multicellular organismal development negative regulation of epithelial cell differentiation tube development negative regulation of developmental process animal organ development biological regulation cell differentiation involved in metanephros development cell differentiation involved in kidney development cellular process kidney development regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to stimulus response to interferon-beta response to organic substance response to cytokine cellular response to interferon-beta cellular response to chemical stimulus cellular response to cytokine stimulus cellular response to organic substance cell population proliferation kidney mesenchymal cell proliferation metanephric mesenchyme development metanephric mesenchymal cell proliferation involved in metanephros development mesenchyme development cell proliferation involved in kidney development kidney mesenchyme development cell proliferation involved in metanephros development mesenchymal cell proliferation defense response response to stress biological process involved in interspecies interaction between organisms immune response response to other organism response to type II interferon defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus signaling cytokine-mediated signaling pathway cellular response to type II interferon cell communication interferon-mediated signaling pathway signal transduction cell surface receptor signaling pathway type II interferon-mediated signaling pathway homeostatic process positive regulation of biological process cell development regulation of cell development positive regulation of developmental process positive regulation of cell differentiation regulation of immune system process myeloid cell homeostasis positive regulation of cellular process erythrocyte homeostasis hemopoiesis regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway response to tumor necrosis factor regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus regulation of defense response to virus defense response to virus regulation of response to stimulus regulation of response to stress positive regulation of defense response to virus by host regulation of defense response to virus by host response to virus response to organonitrogen compound response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to purine-containing compound response to cAMP response to organic cyclic compound negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process response to interleukin-9 interleukin-9-mediated signaling pathway cellular response to interleukin-9 response to hydrogen peroxide response to oxidative stress response to reactive oxygen species response to inorganic substance positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process interferon-alpha production cytokine production regulation of cytokine production regulation of interferon-alpha production positive regulation of type I interferon production type I interferon production positive regulation of interferon-alpha production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production regulation of type I interferon production cellular response to organic cyclic compound cellular response to type I interferon type I interferon-mediated signaling pathway response to type I interferon response to hormone response to endogenous stimulus response to peptide hormone negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of canonical NF-kappaB signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction canonical NF-kappaB signal transduction regulation of cell communication regulation of canonical NF-kappaB signal transduction renal vesicle morphogenesis metanephros morphogenesis animal organ morphogenesis nephron morphogenesis nephron epithelium morphogenesis regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric renal vesicle morphogenesis renal vesicle development negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric nephron development mesenchymal to epithelial transition involved in metanephros morphogenesis mesenchymal to epithelial transition morphogenesis of an epithelium metanephric nephron morphogenesis tissue morphogenesis anatomical structure morphogenesis kidney morphogenesis regulation of viral process negative regulation of viral process regulation by virus of viral protein levels in host cell viral process regulation of biological quality negative regulation by virus of viral protein levels in host cell positive regulation of mesenchymal cell proliferation regulation of mesenchymal cell proliferation regulation of nitric-oxide synthase biosynthetic process nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process metanephric mesenchymal cell differentiation mesenchymal cell differentiation involved in kidney development mesenchymal cell differentiation involved in renal system development mesenchymal cell differentiation response to mechanical stimulus response to abiotic stimulus interleukin-27-mediated signaling pathway foam cell differentiation macrophage derived foam cell differentiation cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT cellular response to nitrogen compound cellular response to peptide hormone stimulus cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to organonitrogen compound response to insulin cellular response to insulin stimulus cellular response to hormone stimulus angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis negative regulation of blood vessel morphogenesis negative regulation of angiogenesis vasculature development circulatory system development negative regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis response to nutrient levels response to nutrient negative regulation of cell population proliferation endothelial cell proliferation negative regulation of endothelial cell proliferation regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation system process circulatory system process blood circulation	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ISGF3 complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure ISGF3 complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle perinuclear region of cytoplasm axon membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen nuclear lumen nucleoplasm
C, D	5-residue peptide	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR035859	STAT1, SH2 domain	Domain
A, B	IPR048988	Signal transducer and activator of transcription, linker domain	Domain
A, B	IPR036535	STAT transcription factor, N-terminal domain superfamily	Homologous Superfamily
A, B	IPR013800	STAT transcription factor, all-alpha domain	Domain
A, B	IPR038295	STAT1, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR036860	SH2 domain superfamily	Homologous Superfamily
A, B	IPR022752	Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal	Domain
A, B	IPR000980	SH2 domain	Domain
A, B	IPR001217	Transcription factor STAT	Family
A, B	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR013799	STAT transcription factor, protein interaction	Domain
A, B	IPR015988	STAT transcription factor, coiled coil	Homologous Superfamily
A, B	IPR013801	STAT transcription factor, DNA-binding	Domain
A, B	IPR012345	STAT transcription factor, DNA-binding, N-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P42224	immunodeficiency 31B chronic mucocutaneous candidiasis mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome rheumatoid arthritis cytomegalovirus infection mycobacterial infectious disease hearing loss disorder Neoplasm Metastasis cirrhosis of liver systemic lupus erythematosus ulcerative colitis Sjogren syndrome Crohn disease hepatocellular carcinoma immunodeficiency 31B chronic mucocutaneous candidiasis mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome rheumatoid arthritis cytomegalovirus infection mycobacterial infectious disease hearing loss disorder Neoplasm Metastasis cirrhosis of liver systemic lupus erythematosus ulcerative colitis Sjogren syndrome Crohn disease hepatocellular carcinoma influenza tuberculosis lung disease exocrine pancreatic carcinoma medulloblastoma glioblastoma Alzheimer disease herpes zoster ovarian cancer autoimmune disease pancreatic intraductal papillary-mucinous neoplasm plasma cell myeloma breast cancer intellectual disability progressive supranuclear palsy celiac disease juvenile dermatomyositis sarcoidosis limb-girdle muscular dystrophy cystic fibrosis lung cancer dermatomyositis malignant ependymoma ductal breast carcinoma in situ malignant pancreatic neoplasm Hashimoto thyroiditis myositis hematologic disease non-small cell lung carcinoma atopic eczema hydrolethalus syndrome pancreatic ductal adenocarcinoma inflammatory bowel disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast carcinoma interstitial cystitis psoriasis juvenile idiopathic arthritis systemic sclerosis lung carcinoma malignant glioma esophageal adenocarcinoma MALT lymphoma Gaucher disease multiple sclerosis head and neck cancer nasopharyngeal carcinoma osteosarcoma atypical teratoid rhabdoid tumor hypothyroidism pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma bacterial infectious disease with sepsis primary biliary cholangitis cancer invasive ductal breast carcinoma chronic obstructive pulmonary disease large cell medulloblastoma skin disease cutaneous lupus erythematosus lung adenocarcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C, D	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.