Annotations: 1YUI

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d1yuia_	Small proteins	beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	Classic zinc finger, C2H2	GAGA factor	(Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2B Superfamily	beta-beta-alpha zinc fingers	8038997	3001077	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	GAGA	e1yuiA1	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: GAGA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	3.30.160.60	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Classic Zinc Finger	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A]	PF09237	GAGA factor (GAGA)	GAGA factor	Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognise ...	Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	DNA (5'-D(GPCPCPGPAPGPAPGPTPAP*C)-3')	-	-	-
B [auth C]	DNA (5'-D(GPTPAPCPTPCPTPCPGPGP*C)-3')	-	-	-
C [auth A]	GAGA-FACTOR	binding organic cyclic compound binding nucleic acid binding protein-containing complex binding chromatin binding protein heterodimerization activity protein binding protein dimerization activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding core promoter sequence-specific DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding chromatin binding protein heterodimerization activity protein binding protein dimerization activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding core promoter sequence-specific DNA binding transcription regulatory region nucleic acid binding transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity transcription factor binding DNA-binding transcription factor activity, RNA polymerase II-specific identical protein binding protein homodimerization activity molecular function activator activity molecular function regulator activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding POZ domain binding protein domain specific binding DNA-binding transcription activator activity, RNA polymerase II-specific	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation cellular component organization nuclear division organelle organization organelle fission cellular component organization or biogenesis cellular developmental process oogenesis cell development cellular process involved in reproduction in multicellular organism female gamete generation cell differentiation anatomical structure development germ cell development cell division maternal-to-zygotic transition of gene expression organonitrogen compound metabolic process amyloid fibril formation protein metabolic process supramolecular fiber organization response to organic substance response to ketone response to sterol response to ecdysone response to stimulus response to lipid response to alcohol response to chemical response to oxygen-containing compound response to organic cyclic compound multicellular organismal process imaginal disc morphogenesis appendage development post-embryonic appendage morphogenesis animal organ development wing disc development imaginal disc-derived wing morphogenesis instar larval or pupal development metamorphosis imaginal disc-derived appendage morphogenesis multicellular organism development anatomical structure morphogenesis wing disc morphogenesis appendage morphogenesis imaginal disc-derived appendage development imaginal disc development instar larval or pupal morphogenesis post-embryonic animal morphogenesis post-embryonic development animal organ morphogenesis protein-DNA complex organization chromatin organization chromatin remodeling protein-containing complex organization sex-chromosome dosage compensation epigenetic regulation of gene expression syncytial blastoderm mitotic cell cycle embryo development mitotic cell cycle mitotic cell cycle, embryonic cell cycle cell cycle comprising mitosis without cytokinesis heterochromatin formation negative regulation of gene expression negative regulation of gene expression, epigenetic positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II nucleosome organization positive regulation of transcription by RNA polymerase II	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle polytene chromosome chromosome cellular anatomical entity non-membrane-bounded organelle protein-containing complex pericentric heterochromatin protein-DNA complex chromatin heterochromatin chromosomal region intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle polytene chromosome chromosome cellular anatomical entity non-membrane-bounded organelle protein-containing complex pericentric heterochromatin protein-DNA complex chromatin heterochromatin chromosomal region chromosome, centromeric region euchromatin membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A]	IPR013087	Zinc finger C2H2-type	Domain
C [auth A]	IPR000210	BTB/POZ domain	Domain
C [auth A]	IPR015318	Zinc finger, GAGA-binding factor	Domain
C [auth A]	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.