1YTZ

Crystal structure of skeletal muscle troponin in the Ca2+-activated state

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth T]	d1ytzt1	Coiled coil proteins	Parallel coiled-coil	Troponin coil-coiled subunits	Troponin T	Troponin T	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B [auth I]	d1ytzi1	Coiled coil proteins	Parallel coiled-coil	Troponin coil-coiled subunits	Troponin I	Troponin I	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
C	d1ytzc_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Troponin C	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth T]	SCOP2 Family	Troponin T	8022503	4003913	SCOP2 (2022-06-29)
A [auth T]	SCOP2 Superfamily	Troponin coil-coiled subunits	8034883	3001782	SCOP2 (2022-06-29)
B [auth I]	SCOP2 Family	Troponin I	8022502	4003914	SCOP2 (2022-06-29)
B [auth I]	SCOP2 Superfamily	Troponin coil-coiled subunits	8034882	3001782	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	EF-hand	8037317	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	PF00036,PF13405	e1ytzC4	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036,PF13405	ECOD (1.6)
C	PF13499	e1ytzC3	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth T]	1.20.5.350	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Troponin complex, TnI/TnT subunit	CATH (4.3.0)
B [auth I]	1.20.5.350	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Troponin complex, TnI/TnT subunit	CATH (4.3.0)
C	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth T]	PF00992	Troponin (Troponin)	Troponin	-	Family
B [auth I]	PF00992	Troponin (Troponin)	Troponin	-	Family
C	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain
C	PF00036	EF hand (EF-hand_1)	EF hand	The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typica ...	The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth T]	Troponin T	cytoskeletal protein binding troponin C binding protein binding binding troponin I binding tropomyosin binding	multicellular organismal movement musculoskeletal movement multicellular organismal process system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction muscle system process striated muscle contraction regulation of biological process regulation of muscle contraction regulation of system process biological regulation multicellular organismal movement musculoskeletal movement multicellular organismal process system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction muscle system process striated muscle contraction regulation of biological process regulation of muscle contraction regulation of system process biological regulation regulation of multicellular organismal process regulation of muscle system process cellular developmental process cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly cell development muscle cell differentiation cellular component organization cellular component biogenesis muscle structure development striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development cell differentiation sarcomere organization anatomical structure development actin filament-based process cellular component organization or biogenesis developmental process actomyosin structure organization actin cytoskeleton organization organelle assembly anatomical structure morphogenesis myofibril assembly organelle organization anatomical structure formation involved in morphogenesis cellular process striated muscle cell differentiation supramolecular fiber organization cytoskeleton organization	striated muscle thin filament protein-containing complex intracellular anatomical structure myofilament cellular anatomical entity actin cytoskeleton sarcomere intracellular organelle troponin complex cytoskeleton organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm striated muscle thin filament protein-containing complex intracellular anatomical structure myofilament cellular anatomical entity actin cytoskeleton sarcomere intracellular organelle troponin complex cytoskeleton organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle
B [auth I]	Troponin I	cytoskeletal protein binding actin binding protein binding binding	multicellular organismal movement musculoskeletal movement multicellular organismal process system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction muscle system process striated muscle contraction heart process circulatory system process cardiac muscle contraction heart contraction multicellular organismal movement musculoskeletal movement multicellular organismal process system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction muscle system process striated muscle contraction heart process circulatory system process cardiac muscle contraction heart contraction blood circulation	striated muscle thin filament protein-containing complex intracellular anatomical structure myofilament cellular anatomical entity actin cytoskeleton sarcomere intracellular organelle troponin complex cytoskeleton organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm striated muscle thin filament protein-containing complex intracellular anatomical structure myofilament cellular anatomical entity actin cytoskeleton sarcomere intracellular organelle troponin complex cytoskeleton organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle
C	Troponin C	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding cytoskeletal protein binding protein binding	multicellular organismal movement musculoskeletal movement multicellular organismal process system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction muscle system process striated muscle contraction	striated muscle thin filament protein-containing complex intracellular anatomical structure myofilament cellular anatomical entity actin cytoskeleton sarcomere intracellular organelle troponin complex cytoskeleton organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm striated muscle thin filament protein-containing complex intracellular anatomical structure myofilament cellular anatomical entity actin cytoskeleton sarcomere intracellular organelle troponin complex cytoskeleton organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth T]	IPR027707	Troponin T	Family
A [auth T]	IPR001978	Troponin	Family
A [auth T]	IPR038077	Troponin domain superfamily	Homologous Superfamily
B [auth I]	IPR001978	Troponin	Family
B [auth I]	IPR038077	Troponin domain superfamily	Homologous Superfamily
C	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
C	IPR002048	EF-hand domain	Domain
C	IPR011992	EF-hand domain pair	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.