Annotations: 1YPH

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth C]	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
E [auth D]	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
C [auth E]	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
F	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth C], E [auth D]	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain
C [auth E], F	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D [auth B]	CHYMOTRYPSIN A, chain A	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity protein binding binding serpin family protein binding	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process multicellular organismal process digestion	protein-containing complex serine protease inhibitor complex protease inhibitor complex peptidase inhibitor complex extracellular region cellular anatomical entity
B [auth C], E [auth D]	CHYMOTRYPSIN A, chain B	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity protein binding binding serpin family protein binding	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process multicellular organismal process digestion	protein-containing complex serine protease inhibitor complex protease inhibitor complex peptidase inhibitor complex extracellular region cellular anatomical entity
C [auth E], F	CHYMOTRYPSIN A, chain C	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity protein binding binding serpin family protein binding	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process multicellular organismal process digestion	protein-containing complex serine protease inhibitor complex protease inhibitor complex peptidase inhibitor complex extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D [auth B]	IPR001254	Serine proteases, trypsin domain	Domain
A, D [auth B]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, D [auth B]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A, D [auth B]	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
A, D [auth B]	IPR001314	Peptidase S1A, chymotrypsin family	Family
A, D [auth B]	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
B [auth C], E [auth D]	IPR001254	Serine proteases, trypsin domain	Domain
B [auth C], E [auth D]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
B [auth C], E [auth D]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
B [auth C], E [auth D]	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
B [auth C], E [auth D]	IPR001314	Peptidase S1A, chymotrypsin family	Family
B [auth C], E [auth D]	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
C [auth E], F	IPR001254	Serine proteases, trypsin domain	Domain
C [auth E], F	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
C [auth E], F	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
C [auth E], F	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
C [auth E], F	IPR001314	Peptidase S1A, chymotrypsin family	Family
C [auth E], F	IPR033116	Serine proteases, trypsin family, serine active site	Active Site

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
B [auth C], C [auth E]	chymotrypsinogen A M-CSA #387	Chymotrypsin is one of the well known serine proteases found in the human digestive system, and is able to catalyse the breakdown of peptide substrates to amino acids, showing a preference for cleavage after aromatic residues such as phenylalanine. The enzyme shares significant sequence and structural homology to many mammalian serine proteases, including trypsin and elastase, as well as being part of a wider family involving proteases from diverse organisms including bacteria.	Defined by 5 residues: HIS:B-42 [auth C-57]ASP:B-87 [auth C-102]GLY:C-45 [auth E-193]SER:C-47 [auth E-195]GLY:C-48 [auth E-196] \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 3.4.21.1 (PDB Primary Data) Search M-CSA Motif + EC 3.4.21.1

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.