Annotations: 1YI5

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1yi5a1	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	(Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
C [auth B]	d1yi5b1	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	(Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
E [auth C]	d1yi5c1	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	(Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
G [auth D]	d1yi5d1	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	(Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
I [auth E]	d1yi5e1	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Acetylcholine binding protein (ACHBP)	(Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
B [auth F]	d1yi5f1	Small proteins	Snake toxin-like	Snake toxin-like	Snake venom toxins	alpha-Cobratoxin	(Naja siamensis ) [TaxId: 84476 ],	SCOPe (2.08)
D [auth G]	d1yi5g1	Small proteins	Snake toxin-like	Snake toxin-like	Snake venom toxins	alpha-Cobratoxin	(Naja siamensis ) [TaxId: 84476 ],	SCOPe (2.08)
F [auth H]	d1yi5h1	Small proteins	Snake toxin-like	Snake toxin-like	Snake venom toxins	alpha-Cobratoxin	(Naja siamensis ) [TaxId: 84476 ],	SCOPe (2.08)
H [auth I]	d1yi5i1	Small proteins	Snake toxin-like	Snake toxin-like	Snake venom toxins	alpha-Cobratoxin	(Naja siamensis ) [TaxId: 84476 ],	SCOPe (2.08)
J	d1yi5j1	Small proteins	Snake toxin-like	Snake toxin-like	Snake venom toxins	alpha-Cobratoxin	(Naja siamensis ) [TaxId: 84476 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
E [auth C]	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
G [auth D]	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
I [auth E]	SCOP2B Superfamily	Nicotinic receptor ligand binding domain-like	8035210	3000369	SCOP2B (2022-06-29)
B [auth F]	SCOP2B Superfamily	Snake toxin-like	8043132	3000545	SCOP2B (2022-06-29)
D [auth G]	SCOP2B Superfamily	Snake toxin-like	8043132	3000545	SCOP2B (2022-06-29)
F [auth H]	SCOP2B Superfamily	Snake toxin-like	8043132	3000545	SCOP2B (2022-06-29)
H [auth I]	SCOP2B Superfamily	Snake toxin-like	8043132	3000545	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Snake toxin-like	8043132	3000545	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Neur_chan_LBD	e1yi5A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
C [auth B]	Neur_chan_LBD	e1yi5B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
E [auth C]	Neur_chan_LBD	e1yi5C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
G [auth D]	Neur_chan_LBD	e1yi5D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
I [auth E]	Neur_chan_LBD	e1yi5E1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
B [auth F]	Toxin_TOLIP	e1yi5F1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Toxin_TOLIP	ECOD (1.6)
D [auth G]	Toxin_TOLIP	e1yi5G1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Toxin_TOLIP	ECOD (1.6)
F [auth H]	Toxin_TOLIP	e1yi5H1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Toxin_TOLIP	ECOD (1.6)
H [auth I]	Toxin_TOLIP	e1yi5I1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Toxin_TOLIP	ECOD (1.6)
J	Toxin_TOLIP	e1yi5J1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Toxin_TOLIP	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B], E [auth C], G [auth D], I [auth E]	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B], E [auth C], G [auth D], I [auth E]	Acetylcholine-binding protein	ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity passive transmembrane transporter activity gated channel activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	-	synaptic cleft extracellular region cellular anatomical entity membrane synapse cell junction
B [auth F], D [auth G], F [auth H], H [auth I], J	Long neurotoxin 1	channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity neurotransmitter receptor regulator activity acetylcholine receptor regulator activity molecular function inhibitor activity acetylcholine receptor inhibitor activity signaling receptor inhibitor activity signaling receptor regulator activity toxin activity	-	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B], E [auth C], G [auth D], I [auth E]	IPR007110	Immunoglobulin-like domain	Domain
A, C [auth B], E [auth C], G [auth D], I [auth E]	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, C [auth B], E [auth C], G [auth D], I [auth E]	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D], I [auth E]	IPR006201	Neurotransmitter-gated ion-channel	Family
B [auth F], D [auth G], F [auth H], H [auth I], J	IPR018354	Snake toxin, conserved site	Conserved Site
B [auth F], D [auth G], F [auth H], H [auth I], J	IPR045860	Snake toxin-like superfamily	Homologous Superfamily
B [auth F], D [auth G], F [auth H], H [auth I], J	IPR003571	Snake three-finger toxin	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.