1YFN

Versatile modes of peptide recognition by the AAA+ adaptor protein SspB- the crystal structure of a SspB-RseA complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1yfna_	All beta proteins	SspB-like	SspB-like	Stringent starvation protein B, SspB	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1yfnc_	All beta proteins	SspB-like	SspB-like	Stringent starvation protein B, SspB	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1yfnd_	All beta proteins	SspB-like	SspB-like	Stringent starvation protein B, SspB	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1yfnb_	All beta proteins	SspB-like	SspB-like	Stringent starvation protein B, SspB	automated matches	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SspB-like	8022001	4000861	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SspB-like	8034381	3001811	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	SspB-like	8034381	3001811	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SspB-like	8034381	3001811	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SspB-like	8034381	3001811	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF04386	e1yfnA1	A: beta barrels	X: SH3	H: SH3	T: Stringent starvation protein B, SspB	F: PF04386	ECOD (1.6)
C	PF04386	e1yfnC1	A: beta barrels	X: SH3	H: SH3	T: Stringent starvation protein B, SspB	F: PF04386	ECOD (1.6)
D	PF04386	e1yfnD1	A: beta barrels	X: SH3	H: SH3	T: Stringent starvation protein B, SspB	F: PF04386	ECOD (1.6)
B	PF04386	e1yfnB1	A: beta barrels	X: SH3	H: SH3	T: Stringent starvation protein B, SspB	F: PF04386	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.220	Mainly Beta	Roll	SH3 type barrels.	SspB-like	CATH (4.3.0)
C	2.30.30.220	Mainly Beta	Roll	SH3 type barrels.	SspB-like	CATH (4.3.0)
D	2.30.30.220	Mainly Beta	Roll	SH3 type barrels.	SspB-like	CATH (4.3.0)
B	2.30.30.220	Mainly Beta	Roll	SH3 type barrels.	SspB-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF04386	Stringent starvation protein B (SspB)	Stringent starvation protein B	-	Family
E, F, G, H	PF03872	Anti sigma-E protein RseA, N-terminal domain (RseA_N)	Anti sigma-E protein RseA, N-terminal domain	Sigma-E is important for the induction of proteins involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and preventing transcription from heat-shock promoters [1]. The C-terminal domain is located in t ...	Sigma-E is important for the induction of proteins involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and preventing transcription from heat-shock promoters [1]. The C-terminal domain is located in the periplasm, and may interact with other protein that signal periplasmic stress.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Stringent starvation protein B	molecular adaptor activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity RNA binding organic cyclic compound binding nucleic acid binding ATPase binding enzyme binding	catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of proteolysis metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process regulation of protein catabolic process positive regulation of molecular function regulation of molecular function regulation of ATP-dependent activity positive regulation of ATP-dependent activity	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex peptidase complex cytosolic proteasome complex HslUV protease complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular organelle organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex peptidase complex cytosolic proteasome complex HslUV protease complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular organelle organelle intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle
E, F, G, H	Sigma-E factor negative regulatory protein	molecular adaptor activity sigma factor antagonist activity transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process	protein-containing complex sigma factor antagonist complex transcription regulator complex cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR007481	Stringent starvation protein B	Family
A, B, C, D	IPR036760	SspB-like superfamily	Homologous Superfamily
E, F, G, H	IPR005573	Anti sigma-E protein RseA, C-terminal	Domain
E, F, G, H	IPR036147	Anti sigma-E protein RseA, N-terminal domain superfamily	Homologous Superfamily
E, F, G, H	IPR026279	Sigma-E factor negative regulatory protein RseA	Family
E, F, G, H	IPR005572	Anti sigma-E protein RseA, N-terminal	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.