1YDL

Crystal Structure of the Human TFIIH, Northeast Structural Genomics Target HR2045.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ydla1	Alpha and beta proteins (a+b)	TFB5-like	TFB5-like	TFB5-like	General transcription factor IIH polypeptide 5, TFB5	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	TFB5-like	8021926	4003379	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	TFB5-like	8034306	3000733	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Tfb5	e1ydlA1	A: a+b complex topology	X: TFB5-related (From Topology)	H: TFB5-related (From Topology)	T: TFB5-related	F: Tfb5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.70.1220	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	TFB5-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF06331	Transcription factor TFIIH complex subunit Tfb5 (Tfb5)	Transcription factor TFIIH complex subunit Tfb5	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	general transcription factor IIH, polypeptide 5	-	cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process transcription initiation at RNA polymerase II promoter cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process transcription initiation at RNA polymerase II promoter cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process macromolecule metabolic process ribonucleoprotein complex biogenesis rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cellular component biogenesis ribosome biogenesis maturation of SSU-rRNA cellular component organization or biogenesis RNA processing rRNA metabolic process ribosomal small subunit biogenesis ncRNA metabolic process nucleic acid catabolic process cellular response to stimulus response to stimulus cellular response to ionizing radiation cellular response to radiation cellular response to environmental stimulus response to ionizing radiation cellular response to gamma radiation response to radiation response to abiotic stimulus cellular response to abiotic stimulus response to gamma radiation DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair transcription elongation by RNA polymerase I transcription by RNA polymerase I rRNA transcription nucleolar large rRNA transcription by RNA polymerase I DNA-templated transcription elongation cellular component organization protein-DNA complex organization cellular component assembly protein-containing complex assembly protein-containing complex organization nucleotide-excision repair, preincision complex assembly protein-DNA complex assembly	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle RNA polymerase II transcription regulator complex protein-containing complex transcription factor TFIIH core complex nuclear protein-containing complex transcription regulator complex RNA polymerase II, holoenzyme transferase complex nucleoplasm catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex cytoplasm protein kinase complex transcription factor TFIIH holo complex carboxy-terminal domain protein kinase complex serine/threonine protein kinase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR009400	TFIIH subunit TTDA/Tfb5	Family
A	IPR035935	TFB5-like superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q6ZYL4	trichothiodystrophy 3, photosensitive trichothiodystrophy photosensitive trichothiodystrophy acute myeloid leukemia glioblastoma leukodystrophy osteosarcoma pilocytic astrocytoma X-linked mixed deafness with perilymphatic gusher atypical teratoid rhabdoid tumor intellectual disability lung cancer ovarian cancer pituitary cancer trichothiodystrophy 1, photosensitive trichothiodystrophy 3, photosensitive trichothiodystrophy photosensitive trichothiodystrophy acute myeloid leukemia glioblastoma leukodystrophy osteosarcoma pilocytic astrocytoma X-linked mixed deafness with perilymphatic gusher atypical teratoid rhabdoid tumor intellectual disability lung cancer ovarian cancer pituitary cancer trichothiodystrophy 1, photosensitive xeroderma pigmentosum Cockayne syndrome large cell medulloblastoma malignant glioma polycystic ovary syndrome

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.