Annotations: 1Y7X

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01505	e1y7xA1	A: beta sandwiches	X: Major vault protein (MVP) structural repeat domain (From Topology)	H: Major vault protein (MVP) structural repeat domain (From Topology)	T: Major vault protein (MVP) structural repeat domain	F: PF01505	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.550	Mainly Beta	Roll	SH3 type barrels.	Major Vault Protein repeat	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01505	Major Vault Protein repeat domain (Vault)	Major Vault Protein repeat domain	The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function [1]. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Major vault protein	protein phosphatase binding phosphatase binding protein binding binding enzyme binding kinase binding protein kinase binding identical protein binding	RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport protein localization establishment of protein localization RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport protein localization establishment of protein localization cellular localization protein transport cellular macromolecule localization cellular process regulation of cellular process negative regulation of protein tyrosine kinase activity regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of transferase activity negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process negative regulation of protein modification process protein modification process phosphorus metabolic process negative regulation of protein metabolic process regulation of biological process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of molecular function regulation of protein tyrosine kinase activity regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification metabolic process regulation of phosphorus metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process peptidyl-tyrosine modification organic substance metabolic process negative regulation of cellular process protein metabolic process negative regulation of macromolecule metabolic process negative regulation of peptidyl-tyrosine phosphorylation organonitrogen compound metabolic process regulation of peptidyl-tyrosine phosphorylation biological regulation negative regulation of molecular function regulation of macromolecule metabolic process regulation of protein kinase activity negative regulation of protein kinase activity negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation peptidyl-tyrosine phosphorylation protein autophosphorylation regulation of protein autophosphorylation negative regulation of protein autophosphorylation cellular response to stimulus response to stimulus signaling negative regulation of signaling negative regulation of ERBB signaling pathway regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cell communication cell communication regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling regulation of ERBB signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus negative regulation of epidermal growth factor receptor signaling pathway ERBB signaling pathway regulation of cell communication	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol protein-containing complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope nuclear envelope nuclear pore membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular organelle lumen organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle cytoskeleton intracellular non-membrane-bounded organelle non-membrane-bounded organelle vesicle lumen cytoplasmic vesicle lumen secretory granule lumen perinuclear region of cytoplasm ribonucleoprotein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR041136	Major vault protein repeat domain 4	Domain
A	IPR036013	Band 7/SPFH domain superfamily	Homologous Superfamily
A	IPR041139	Major vault protein repeat domain	Domain
A	IPR043023	Major vault protein repeat domain superfamily	Homologous Superfamily
A	IPR043179	Major vault protein repeat domain 2 superfamily	Homologous Superfamily
A	IPR040989	Major vault protein repeat domain 3	Domain
A	IPR039059	Major vault protein	Family
A	IPR002499	Major vault protein, N-terminal	Repeat
A	IPR021870	Major vault protein, shoulder domain	Domain
A	IPR041134	Major vault protein repeat domain 2	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q14764	Liver Cirrhosis, Experimental autism spectrum disorder juvenile dermatomyositis malignant mesothelioma osteoarthritis susceptibility 1 pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma dental caries myopathy pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma tuberculosis glioblastoma malignant ependymoma Liver Cirrhosis, Experimental autism spectrum disorder juvenile dermatomyositis malignant mesothelioma osteoarthritis susceptibility 1 pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma dental caries myopathy pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma tuberculosis glioblastoma malignant ependymoma osteoarthritis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.