1Y7H

Structural and biochemical studies identify tobacco SABP2 as a methylsalicylate esterase and further implicate it in plant innate immunity, Northeast Structural Genomics Target AR2241

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1y7ha_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Hydroxynitrile lyase-like	Salicylic acid-binding protein 2 (SABP2)	common tobacco (Nicotiana tabacum ) [TaxId: 4097 ],	SCOPe (2.08)
B	d1y7hb_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Hydroxynitrile lyase-like	Salicylic acid-binding protein 2 (SABP2)	common tobacco (Nicotiana tabacum ) [TaxId: 4097 ],	SCOPe (2.08)
C	d1y7hc_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Hydroxynitrile lyase-like	Salicylic acid-binding protein 2 (SABP2)	common tobacco (Nicotiana tabacum ) [TaxId: 4097 ],	SCOPe (2.08)
D	d1y7hd_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Hydroxynitrile lyase-like	Salicylic acid-binding protein 2 (SABP2)	common tobacco (Nicotiana tabacum ) [TaxId: 4097 ],	SCOPe (2.08)
E	d1y7he_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Hydroxynitrile lyase-like	Salicylic acid-binding protein 2 (SABP2)	common tobacco (Nicotiana tabacum ) [TaxId: 4097 ],	SCOPe (2.08)
F	d1y7hf_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Hydroxynitrile lyase-like	Salicylic acid-binding protein 2 (SABP2)	common tobacco (Nicotiana tabacum ) [TaxId: 4097 ],	SCOPe (2.08)
G	d1y7hg_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Hydroxynitrile lyase-like	Salicylic acid-binding protein 2 (SABP2)	common tobacco (Nicotiana tabacum ) [TaxId: 4097 ],	SCOPe (2.08)
H	d1y7hh_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Hydroxynitrile lyase-like	Salicylic acid-binding protein 2 (SABP2)	common tobacco (Nicotiana tabacum ) [TaxId: 4097 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	alpha/beta-Hydrolases	8043965	3000102	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	alpha/beta-Hydrolases	8043965	3000102	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	alpha/beta-Hydrolases	8043965	3000102	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	alpha/beta-Hydrolases	8043965	3000102	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	alpha/beta-Hydrolases	8043965	3000102	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	alpha/beta-Hydrolases	8043965	3000102	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	alpha/beta-Hydrolases	8043965	3000102	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	alpha/beta-Hydrolases	8043965	3000102	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hydrolase_4_1	e1y7hA1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_1	ECOD (1.6)
B	Hydrolase_4_1	e1y7hB1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_1	ECOD (1.6)
C	Hydrolase_4_1	e1y7hC1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_1	ECOD (1.6)
D	Hydrolase_4_1	e1y7hD1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_1	ECOD (1.6)
E	Hydrolase_4_1	e1y7hE1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_1	ECOD (1.6)
F	Hydrolase_4_1	e1y7hF1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_1	ECOD (1.6)
G	Hydrolase_4_1	e1y7hG1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_1	ECOD (1.6)
H	Hydrolase_4_1	e1y7hH1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
B	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
C	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
D	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
E	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
F	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
G	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
H	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF12697	Alpha/beta hydrolase family (Abhydrolase_6)	Alpha/beta hydrolase family	This family contains alpha/beta hydrolase enzymes of diverse specificity.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	salicylic acid-binding protein 2	hydrolase activity, acting on ester bonds hydrolase activity catalytic activity lipase activity carboxylic ester hydrolase activity methyl jasmonate esterase activity methyl salicylate esterase activity methyl indole-3-acetate esterase activity	biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus benzene-containing compound metabolic process biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus benzene-containing compound metabolic process oxoacid metabolic process organic hydroxy compound metabolic process cellular metabolic process carboxylic acid metabolic process salicylic acid metabolic process organic acid metabolic process organic cyclic compound metabolic process organic substance metabolic process phenol-containing compound metabolic process metabolic process small molecule metabolic process cellular process monocarboxylic acid metabolic process fatty acid metabolic process long-chain fatty acid metabolic process jasmonic acid metabolic process primary metabolic process cellular lipid metabolic process lipid metabolic process cellular response to stimulus response to organic substance regulation of cellular process signaling response to salicylic acid cell communication signal transduction cellular response to organic substance salicylic acid mediated signaling pathway response to organic cyclic compound cellular response to salicylic acid stimulus systemic acquired resistance regulation of biological process biological regulation cellular response to organic cyclic compound response to oxygen-containing compound systemic acquired resistance, salicylic acid mediated signaling pathway cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000073	Alpha/beta hydrolase fold-1	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR045889	Methylesterase/Alpha-hydroxynitrile lyase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.